Dyspepsia Flashcards

1
Q

True or False: Dyspepsia is a condition.

A

False, it is a symptom.

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2
Q

How can dyspepsia be described by a patient?

A
  • Epigastric pain
  • Heartburn
  • Indigestion
  • Pain/better with eating
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3
Q

Give some diagnosis of having dyspepsia.

A
  • Malignancy
  • Gastroenteritis
  • Coeliac Disease
  • Crohn’s Disease
  • IBS
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4
Q

What do we do when patients may have dyspepsia?

A

Initial Investigation
- Alarm symptoms (Frequency, duration)
- Family (malignancy) and social history (Drinking, smoking, foods)
- Stress, anxiety, depression
- Patients medication
- Examine person: Weight loss, anaemia, abdominal masses/tenderness
- Raised platelet count

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5
Q

When you examine a patient, how do you assess them for signs of anaemia?

A
  • Symptoms: Pallor, fatigue
    -> Blood test
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6
Q

Why is it important to check anaemia if a patient is presenting with symptoms like dyspepsia?

A

It could suggest a GI bleed resulting in the loss of blood.

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7
Q

When a patient is presenting with symptoms like dyspepsia, what does a raised platelet count suggest? What is a raised platelet count called?

A

Malignancy.
-> Thrombocytosis

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8
Q

A patient who is over the age of 55 and has a new symptom of dyspepsia could possibly have what?

A

Malignancy -> Referred

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9
Q

True or False: If a patient is presenting with alarm symptoms but they under the age of 55, they shouldn’t be referred.

A

False. Clinical judgement should be used because even if the patient is slightly younger, they are still presenting with alarm symptoms.

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10
Q

What should patients be referred for if they are presenting with dyspepsia symptoms?

A

Endoscopy

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11
Q

What are some alarm symptoms?

A
  • Abdominal distension
  • Abdominal masses
  • Abdominal pain
  • Change in bowel habit
  • Dyspepsia
  • Dysphagia
  • Nausea and Vomiting
  • Reflux
  • Haematemesis
  • Rectal bleeding
  • Weight loss
  • Anaemia
  • Raised platelet count
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12
Q

When may patients be referred for endoscopy?

A
  • New dyspepsia symptom
  • 55 and over
  • Weight loss
  • Raised platelet count
  • Nausea and vomiting
  • Reflux
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13
Q

How can we treat patients with no alarm symptoms?

A
  • Lifestyle counselling: Healthy eating, weight reduction, smoking cessation, alcohol reduction
  • Address stress, anxiety, depression
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14
Q

How is a patient diagnosed if they have a dyspepsia symptom but they have not been referred for an endoscopy?

A

Uninvestigated dyspepsia

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15
Q

How is uninvestigated dyspepsia treated?

A

One of the following:
- PPI for 4 weeks (lansoprazole, omeprazole)
- H.Pylori test and treat (breath/stool antigen test)

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16
Q

How is a H. Pylori tested?

A

Breath test:
1. Breathe into tube
2. Take urea tablet
-> H.Pylori will break down urea into ureases
4. Breathe back into tube
5. Positive

17
Q

How is H.Pylori treated?

A

2 Antibiotics + 1 PPI
-> 7 days

18
Q

What should be taken into account before a H.Pylori test?

A
  • Antibiotics completed 28 days prior to test (can give false positive)
  • PPIs stopped 14 days before test
  • Stop H2RAs 3 days before test
  • Can’t eat or drink 6 hours prior to test
19
Q

Give some examples of PPIs.

A
  • Lansoprazole
  • Omeprazole
  • Esomeprazole
20
Q

Give some examples of antibiotics given for H.Pylori.

A
  • Amoxicillin
  • Clarithromycin
  • Metronidazole
21
Q

Which 2 antibiotics are usually given if a patient is allergic to penicillin.

A
  • Clarithromycin
  • Metronidazole
22
Q

Which patient group should not be given metronidazole?

A

Patient’s who are alcohol dependent as it can make them ill.

23
Q

Which antibiotic interacts with a lot of drugs?

A

Clarithromycin

24
Q

If a patient with uninvestigated dyspepsia has had treatment with PPIs and antibiotics and their symptoms don’t improve, what should be done next?

A
  • Assess alarm symptoms
  • Alternative diagnosis
  • Adherence to lifestyle advice and medications
  • Consider H2RAs
  • Long-term acid suppression therapy
  • Review NSAIDs/antiplatelets
25
When may a patient be retested for H.Pylori?
- Poor compliance to therapy - Family history of malignancy - Same symptoms
26
A patient who had an endoscopy due to dyspepsia symptoms can be diagnosed with what?
- Functional dyspepsia - GORD - PUD - Malignancy
27
How is functional dyspepsia treated?
Test and treat for H.Pylori - Low dose PPI or standard-dose H2RA
28
What are the 2 conditions of GORD when diagnosing through endoscopy?
- Oesophagitis - Endoscopy-negative reflux disease (symptoms of GORD but endoscopy normal)
29
True or False: H.Pylori can affect GORD.
False, GORD is only affected by the dysfunction if the lower oesophageal sphincter.
30
What are some risk factors of GORD?
- Lifestyle factors: Obesity, trigger foods, smoking, alcohol, stress - Medications (CCB) - Pregnancy
31
How is GORD treated?
- Lifestyle advice - Review and stop any drugs which exacerbate symptoms - Full-dose PPI -> 8 weeks to promote full healing of oesophagitis
32
If GORD symptoms still persist after initial treatment, what should be done next?
- Consider alternative diagnosis - Lifestyle advice - Regular PPI
33
How is Peptic Ulcer Disease treated?
- Test and treat H.Pylori -> make sure patient isn’t on NSAID as can cause ulcerations - No H.Pylori? Give PPI
34
What are the effects of long-term use of PPIs?
- Can cause fractures - Increased risk of GI infections (clostridium difficile) - Can mask signs and symptoms of gastric cancers (Heal over ulcers and masses)
35
How can PPIs be dangerous if someone has a possible cancer?
They can mask danger symptoms and symptoms become more manageable -> more difficult to detect.
36
When a patient is on a PPI, what should be monitored and measure?
Magnesium and Sodium levels
37
How do PPIs interact with Clopidogrel?
Clopidogrel converted to active form by CYP450 enzyme -> PPIs block enzyme and stop clopidogrel from converting into its active form