Dysmenorrhea or Amenorrhea Flashcards

1
Q

Why should copper IUD not be used for dysmenorrhea?

A

Can lead to even heavier bleeding; is only used for contraception

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2
Q

How do OCPs relieve dysmenorrhea?

A

Progestin –> endometrial atrophy –> decreased prostaglandin production –> improved dysmenorrhea

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3
Q

Risks of depo medroxyprogesterone acetate

A

Gaining weight
Depression

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4
Q

What are causes of secondary dymenorrhea?

A

Endometriosis
Adenomyosis
Fibroids
Pelvic inflammatory disease from STIs (e.g. Chlamydia) or adhesions
Ovarian cysts

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5
Q

in whom are oral contraceptive pills contraindicated?

A

Smokers
>age 35

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6
Q

What demographic more likely has adenomyosis?

A

Older multiparous women

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7
Q

Women >45 yo (late reproductive years and older) with abnormal uterine bleeding should receive what?

A

Endometrial biopsy - to rule out endometrial hyperplasia or cancer

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8
Q

How would pathology show endometriosis?

A

Endometrial glands/stroma and hemosiderin-laden macrophages outside the uterine cavity

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9
Q

What is indicated by well-circumscribed, non-encapsulated myometrium?

A

Fibroids

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10
Q

What fibroid location is less likely to cause pain with menstruation?

A

Subserosal

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11
Q

Endometrial polyps are most common in which women, and how do they present?

A

Age 40-50; increased menstrual flow with increased cramping, as well as intermenstrual spotting

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12
Q

What is red/carneous degeneration?

A

Fibroid growth in pregnancy that may become symptomatic due to hemorrhagic changes associated with rapid growth

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13
Q

In whom might myotectomy be preferred over hysterectomy?

A

Younger patients with fibroids who want to preserve fertility

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14
Q

How long after GnRH agonist cessation do things return?

A

Hot flashes end by 1-2 months after
Myoma and uterine size return to pretreatment levels in 3-4 months

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15
Q

When does fibroid degeneration happen?

A

When it outgrows its blood supply and is independent of the use of GnRH agonist

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16
Q

What hormone labs in workup for hyperandrogenism?

A

DHEAS (for adrenal tumor)
17-OH progesterone (for late-onset 21-hydroxylase deficiency)
Testosterone (androgen secreting tumor)

17
Q

What are symptoms of premature ovarian failure?

A

Hot flashes
Insertional dyspareunia

Hypergonadotropic amenorrhea could be due to ovarian failure or follicular resistance to gonadotropins

18
Q

What types of patients typically have hypothalamic amenorrhea?

A

Female athlete triad
Nutritional deficiency

19
Q

What is the definition of oligomenorrhea?

A

Periods occur >35 days apart
Periods <9 per year

20
Q

What test if suspect Cushing’s syndrome?

A

Overnight dexamethasone suppression test for measuring cortisol

21
Q

What tests if suspect PCOS?

A

Pelvic ultrasound
Insulin
Testosterone (to rule out androgen secreting tumor)

22
Q

Rotterdam criteria for PCOS

A

2 of 3:
1. Chronic anovulation
2. Hyperandrogenism (clinical/biologic)
3. Polycystic ovaries on US

Need testosterone to rule out androgen secreting tumor if diagnosing without US

23
Q

Why can patients have hair loss postpartum?

A

High estrogen during pregnancy increases synchrony of hair growth; postpartum telogen effluvium may occur

24
Q

What drug can be added to OCPs to help with hirsutism?

A

Spironolactone

25
Q

How does a ruptured ectopic pregnancy cause fecal urgency?

A

Blood pools in posterior cul-de-sac, increasing rectal pressure and resulting in urge to defecate

26
Q

What is pelvic congestion syndrome?

A

Dull, ill-defined pelvic pain from long standing or intercourse that is present before and relieved by menses

27
Q

Accelerated follicle depletion can be seen in women with what family history?

A

Fragile X syndrome - premutation carriers overexpress FMR1, with cytotoxic effect on follicles

28
Q

PCOS treatment for those who don’t want to conceive vs do

A

Don’t want to conceive: OCPs or progestin +/- spironolactone
Do: Letrozole (aromatase inhibitor) +/- metformin for ovulation; clomiphene (SERM) second-line