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PHRM840 > Dyslipidemia Medication Formulary > Flashcards

Dyslipidemia Medication Formulary Flashcards

1
Q

atorvastatin brand names

A

Atorvaliq
Lipitor

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2
Q

atorvastatin dosing

A

-10-20 mg/day (moderate intensity)
-40-80 mg/day (high intensity)

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3
Q

atorvastatin adverse effects

A

-diarrhea
-arthralgia
-nasopharyngitis

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4
Q

atorvastatin monitoring parameters

A

-lipid panel
-hepatic transaminase levels
-signs/symptoms of myopathy/rhabdomyolysis

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5
Q

rosuvastatin brand names

A

Crestor
Ezallor Sprinkle

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6
Q

rosuvastatin dosing

A

-5-10 mg/day (moderate intensity)
-20-40 mg/day (high intensity)

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7
Q

rosuvastatin adverse effect

A

myalgia

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8
Q

rosuvastatin monitoring parameters

A

-lipid panel
-hepatic transaminase levels

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9
Q

simvastatin brand names

A

FloLipid
Zocor

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10
Q

simvastatin dosing

A

20-40 mg/day

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11
Q

simvastatin adverse effects

A

-atrial fibrillation
-edema
-eczema
-abdominal pain
-constipation
-gastritis
-nausea
-cystitis
-increased serum transaminases
-headache
-vertigo
-increased creatine phosphokinase in blood specimen
-myalgia
-bronchitis
-upper respiratory infection

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12
Q

simvastatin monitoring parameters

A

-lipid panel
-hepatic transaminase levels

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13
Q

pravastatin brand name

A

Pravachol

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14
Q

pravastatin dosing

A

40-80 mg/day

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15
Q

pravastatin adverse effects

A

-musculoskeletal pain
-upper respiratory tract infection

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16
Q

pravastatin monitoring parameters

A

-lipid panel
-hepatic transaminase levels

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17
Q

lovastatin brand name

A

Altoprev

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18
Q

lovastatin dosing

A

-20 mg/day (low intensity)
-40-80 mg/day (moderate intensity)

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19
Q

lovastatin adverse effects

A

-infection
-increased creatine phosphokinase in blood specimen

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20
Q

lovastatin monitoring parameters

A

-lipid panel
-hepatic transaminase levels

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21
Q

pitavastatin brand names

A

Livalo
Zypitamag

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22
Q

pitavastatin dosing

A

1-4 mg/day

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23
Q

pitavastatin adverse effects

A

-constipation
-diarrhea
-back pain
-myalgia

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24
Q

pitavastatin monitoring parameters

A

-lipid panel
-hepatic transaminase levels

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25
Q

fluvastatin brand name

A

Lescol XL

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26
Q

fluvastatin dosing

A

-20-40 mg/day (low intensity)
-80 mg/day (moderate intensity)

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26
Q

fluvastatin monitoring parameters

A

-lipid panel
-hepatic transaminase levels

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26
Q

fluvastatin adverse effects

A

-headache
-fatigue
-insomnia
-dyspepsia
-abdominal pain
-diarrhea
-nausea
-urinary tract infection
-myalgia
-sinusitis
-bronchitis

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27
Q

ezetimibe brand name

A

Zetia

28
Q

ezetimibe dosing

A

10 mg PO QD

29
Q

ezetimibe adverse effects

A

-increased serum transaminases
-arthralgia
-sinusitis
-upper respiratory tract infection

30
Q

ezetimibe monitoring parameters

A

-lipid panel
-hepatic transaminase levels

31
Q

evolocumab brand names

A

Repatha
Repatha Pushtronex System
Repatha SureClick

32
Q

evolocumab dosing

A

-140 mg SQ Q2W
-420 mg SQ once monthly

33
Q

evolocumab adverse effects

A

-headache
-nasopharyngitis

34
Q

evolocumab monitoring parameters

A

-lipid profile before initiating treatment
-fasting lipid profile 4-12 weeks after starting therapy; every 3-12 months thereafter
-signs/symptoms of hypersensitivity reactions

35
Q

alirocumab brand name

A

Praluent

36
Q

alirocumab dosing

A

-start at 75 mg SQ Q2W or 300 mg SQ Q4W
-can increase up to 150 mg SQ Q2W

37
Q

alirocumab adverse effect

A

injection site reaction

38
Q

alirocumab monitoring parameters

A

-lipid profile before initiating treatment
-fasting lipid profile 4-12 weeks after starting therapy; every 3-12 months thereafter
-for patients taking 300 mg Q4W, measure LDL-C before next scheduled dose
-signs/symptoms of hypersensitivity reactions

39
Q

cholestyramine brand names

A

Prevalite
Questran
Questran Light

40
Q

cholestyramine dosing

A

-start at 4 g PO QD/BID; increase gradually over the course of at least 1 month
-4-8 g/day PO BID
-max dose: 24 g/day

41
Q

cholestyramine adverse effect

A

constipation

42
Q

cholestyramine monitoring parameters

A

-lipid profile before initiating treatment
-fasting lipid profile 4-12 weeks after starting therapy; every 3-12 months thereafter

43
Q

colesevelam brand name

A

Welchol

44
Q

colesevelam dosing

A

-3.75 g PO QD
-1.875 g PO BID

45
Q

colesevelam adverse effect

A

constipation

46
Q

colesevelam monitoring parameters

A

lipid profile 4-12 weeks after starting therapy; every 3-12 months thereafter

47
Q

colestipol brand names

A

Colestid
Colestid Flavored

48
Q

colestipol dosing

A

-granules: start at 5 g PO QD/BID; increase by 5 g/day at 1-2 month intervals; maintenance: 5-30 g/day PO QD or in divided doses
-tablets: start at 2 g PO QD/BID; increase by 2 g PO QD/BID at 1-2 month intervals; maintenance: 2-16 g/day PO QD or in divided doses

49
Q

colestipol adverse effects

A

-constipation
-diarrhea
-abdominal pain
-nausea
-vomiting
-heartburn
-stomach cramps
-flatulence
-muscle or joint pain
-headache

50
Q

colestipol monitoring parameters

A

-lipid profile before initiating treatment
-fasting lipid profile 4-12 weeks after starting therapy; every 3-12 months thereafter

51
Q

fenofibrate brand names

A

Antara
Fenoglide
Lipofen
Lofibra
TriCor
Triglide

52
Q

fenofibrate dosing

A

-Antara: 130 mg PO QD
-Lipofen: 150 mg PO QD
-Lofibra: 200 mg PO QD (high cholesterol) or 67 mg PO QD (severe hypertriglyceridemia)
-Fenoglide: 120 mg PO QD
-Tricor: 160 mg PO QD
-Triglide: 160 mg PO QD

53
Q

fenofibrate adverse effects

A

-increased serum alanine aminotransferase
-increased serum aspartate aminotransferase

54
Q

fenofibrate monitoring parameters

A

-periodic blood counts during first year of therapy
-lipid profile within few months of initiation of therapy
-LFTs at baseline and periodically during therapy
-kidney function for patients with kidney impairment
-signs/symptoms of myopathy, myositis, or rhabdomyolysis

55
Q

gemfibrozil brand name

A

Lopid

56
Q

gemfibrozil dosing

A

600 mg PO BID 30 minutes before breakfast and dinner

57
Q

gemfibrozil adverse effect

A

dyspepsia

58
Q

gemfibrozil monitoring parameters

A

-serum cholesterol
-LFTs periodically
-CBC periodically during first year of therapy

59
Q

omega-3 fatty acid brand name

A

Lovaza

60
Q

omega-3 fatty acid dosing

A

-4 g PO QD
-2 g PO BID

61
Q

omega-3 fatty acid adverse effects

A

-dysgeusia
-dyspepsia
-eructation

62
Q

omega-3 fatty acid monitoring parameters

A

-triglycerides and other lipids at baseline and periodically
-hepatic transaminase levels periodically for patients with hepatic impairment
-signs/symptoms of bleeding

63
Q

icosapent ethyl brand name

A

Vascepa

64
Q

icosapent ethyl dosing

A

2 g PO BID with meals

65
Q

icosapent ethyl adverse effect

A

hemorrhage

66
Q

icosapent ethyl monitoring parameters

A

-triglycerides and other lipids at baseline and periodically
-ALT and AST periodically for patients with hepatic impairment
-signs/symptoms of bleeding

67
Q

niacin brand names

A

Niacin-50
Niacor
Niaspan
Slo-Niacin

68
Q

niacin dosing

A

500-2000 mg PO QD-TID

69
Q

niacin adverse effects

A

-flushing
-itching
-diarrhea
-nausea
-vomiting
-cough
-dry skin
-headache

70
Q

niacin monitoring parameters

A

-blood glucose for diabetic patients
-CPK and serum potassium periodically if on concurrent HMG-CoA reductase inhibitor
-liver function tests pretreatment, every 6-12 weeks for first year of therapy, periodically thereafter
-lipid profile
-platelets and PT if on anticoagulants
-uric acid if predisposed to gout
-phosphorus if predisposed to hypophosphatemia

PHRM840 (2 decks)

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