Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Therapeutics 2 - Exam 5 > Dyslipidemia lab > Flashcards

Dyslipidemia lab Flashcards

1
Q

Atorvastatin brand

A

Lipitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

rosuvastatin brand

A

crestor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

simvastatin brand

A

zocor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

pravastatin brand

A

pravachol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

lovastatin brand

A

altoprev
mevacor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

pitavastatin brand

A

livalo

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

fluvastatin brand

A

lescol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

statin MOA

A

HMG-CoA reductase inhibitors that up-regulate LDL receptors and reduce cholesterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

statin AE

A

serious muscle toxicity (myopathy, rhabdomyolysis)
hepatotoxicity
increased incidence of T2DM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

statin CI

A

acute liver disease
unexplained/persistent elevations of serum transaminases
pregnancy
breastfeeding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

simvastatin drug-interactions (CI)

A

itraconazole
ketoconazole
posaconazole
erythromycin
clarithromycin
telithromycin
HIV protease inhibitors
nefazodone
gemfibrozil
cyclosporine
danazol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

simvastatin dosage considerations

A
  1. dont exceed 10mg simvastatin daily with verapamil or diltiazem
  2. dont exceed 20mg simvastatin daily with amiodarone, amlodipine, or ranolazine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what are the 4 statin monitoring parameters?

A

FLP
LFTs
CK
Hepatic function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

how should FLP be monitored in statins?

A

at baseline
4-12 weeks after initiation
then every 3-12 months

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

how should LFTs be monitored in statins?

A

baseline and repeat as clinically needed
discontinue treatment if LFTs exceed 3x ULN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

how should CK be monitored in statins?

A

consider in patients at risk or those experiencing muscle symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

how should hepatic function be monitored in statins?

A

consider assessing in patients with signs of hepatotoxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

ezetimibe brand

A

zetia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

zetia MOA

A

cholesterol absorption inhibitor that inhibits NPC1L1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

zetia AE

A

fatigue
diarrhea
GI upset

21
Q

zetia CI

A

same as statins when used concomitantly with them

22
Q

evolocumab brand

A

repatha

23
Q

alirocumab brand

A

praluent

24
Q

MOA of repatha/praluent

A

PCSK-9 inhibitors that promote the degradation of LDL receptors in the liver

25
Q

PCSK9 inhibitors AE

A

gi upset
increased LFTs
injection site reaction
arthralgia
myalgia
influenza

26
Q

cholestyramine brand

A

questran

27
Q

colsevelem brand

A

welchol

28
Q

colestipol brand

A

colestid

29
Q

MOA of of the coles

A

bile acid sequestrants that inhibit bile acid reabsorption and up-regulate LDL receptors

30
Q

bile acid sequestrants AE

A

constipation
bloating
N
flatulence
impaired absorption of fat soluble vitamins (ADEK)
hypernatremia
hypercholermia
GI obstruction

31
Q

cholestyramine CI

A

complete biliary obstruction

32
Q

colesevelam CI

A

history of bowel obstruction
TG over 500mg/dL
history of hypertriglyceridemia-induced pancreatitis

33
Q

bile acid sequestrant counseling

A

take other medications 1 hour before or 4 hours after BARS
may increase TGs

34
Q

fenofibrate brand

A

tricor

35
Q

gemfibrozil brand

A

lopid

36
Q

MOA of fibrates

A

peroxisome proliferator-activated receptor-alpha activators that regulate gene transcription with retinoic acid receptor (RXR)

37
Q

fibrates AE

A

GI disturbances
rash
myalgia
dizziness
gallstones
rhabdomyolysis

38
Q

fibrates CI

A

history of gallbladder disease
ESRD
dialysis
persistent liver disease

39
Q

fibrates counseling

A

use with caution with statins
may potentiate the effects of warfarin, statins, zetia, or sulfonylureas

40
Q

omega-3 fatty acid brand

A

lovaza

41
Q

icosapent ethyl brand

A

vascepa

42
Q

icosapent ethyl MOA

A

omega-3 fatty acid that reduces TGs

43
Q

Omega-3 fatty acids AE

A

increased LDL levels
GI disturbances
fishy taste/smell
belching

44
Q

niacin brand

A

niacor

45
Q

niacin MOA

A

vitamin that can reduce LDL and serum triglyercides at high doses

46
Q

niacin AE

A

flushing
itching
tingling of upper body
headache
hepatotoxicity
hyperuricemia
hyperglycemia
increases LFTs
increased levels of statins

47
Q

niacin CI

A

active hepatic disease
significant/unexplained persistent liver transaminase elevations
active peptic ulcer
arterial hemorrhage

48
Q

niacin counseling

A

take aspirin 325mg 30 minutes before taking niacin
take close to meal times
avoid alcohol and hot drinks

Therapeutics 2 - Exam 5 (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions