Dyslipidemia - Hockerman and Chaudry

Question 1

Cholesterol

Answer 1

essential component of cell membranes

precursor to sterols and steroids

Question 2

Triglyceride

Answer 2

storage form of fuel to support generation of high energy compounds

components of structural lipids

Question 3

_____ and ______ are transported in blood in macromolecular aggregates known as ____________.

Answer 3

cholesterol, triglyceride, lipoproteins

Question 4

lipoproteins

Answer 4

transport cholesterol and triglycerides in the blood

Question 5

apoproteins

Answer 5

located on the surface of lipoproteins and are critical in regulating transport and metabolism

Question 6

lipoprotein lipase system

Answer 6

releases free fatty acids from lipoproteins

Question 7

Chylomycrons

Answer 7

involved in the transport of dietary lipids from gut to liver and adipose tissue

Question 8

VLDL (very low density lippoprotein)

Answer 8

secreted by the liver into blood as a source of triglycerides

Question 9

IDL (intermediate density lippopprotein)

Answer 9

triglyceride depleted VLDLs

Question 10

LDL (low density lipoprotein)

Answer 10

main cholesterol form in the blood

Question 11

HDL (high density lipoprotein)

Answer 11

secreted by liver and acquire cholesterol from peripheral tissues and atheromas (reverse cholesterol transport - bringing it back to the liver)

Question 12

ApoA-1 produced in the ______

Answer 12

liver and intestine

Question 13

ApoA-1 role

Answer 13

structural in HDL

ligand of ABCA1 receptor

mediates reverse cholesterol transport

Question 14

ApoB-100 produced in the _____

Answer 14

liver

Question 15

ApoB-100 role

Answer 15

structural in VLDL, IDL, LDL

LDL receptor ligand

Question 16

ApoB-48 produced in the ______

Answer 16

intestine

Question 17

ApoB-48 role

Answer 17

structural in chylomicrons

Question 18

ApoE produced in the _______

Answer 18

liver and other tissues

Question 19

ApoE role

Answer 19

reverse cholesterol transport with HDL

ligand for LDL remnant receptor

Question 20

ApoCII role

Answer 20

binds to lipoprotein lipase to enhance triglyceride hydrolysis

Question 21

lipoprotein lipase

Answer 21

in capillaries of fat, cardiac & skeletal muscle