dyslipidemia

Question 1

What are HMG-CoA Reductase Inhibitors commonly known as?

Answer 1

Statins

Statins are a class of drugs used to lower cholesterol levels.

Question 2

Name two pro-drug statins.

Answer 2

• Lovastatin
• Simvastatin

Pro-drugs require metabolic conversion to become active.

Question 3

List three statins.

Answer 3

• Atorvastatin
• Rosuvastatin
• Fluvastatin

Statins are commonly prescribed to manage dyslipidemia.

Question 4

What vitamin is also known as Niacin?

Answer 4

Vitamin-B₃

Niacin is important for metabolic processes and can affect lipid levels.

Question 5

What are the two formulations of Niacin?

Answer 5

• Immediate-release (Regular or Crystalline)
• Extended-release (NIASPAN)

Different formulations may have varying effects and side effects.

Question 6

What class of drugs do Fibric Acid Derivatives belong to?

Answer 6

PPAR-α Agonists

PPAR-α Agonists help regulate lipid metabolism.

Question 7

Name two examples of Fibric Acid Derivatives.

Answer 7

• Gemfibrozil
• Fenofibrate

These drugs are often used to lower triglyceride levels.

Question 8

What are Bile Acid Sequestrants used for?

Answer 8

Lowering cholesterol levels

They work by binding bile acids in the intestine.

Question 9

List three examples of Bile Acid Sequestrants.

Answer 9

• Cholestyramine
• Colestipol
• Colesevelam

These agents are used in the management of hyperlipidemia.

Question 10

What is the function of a Cholesterol Absorption Inhibitor?

Answer 10

Inhibit the absorption of cholesterol in the intestine

This can help lower overall cholesterol levels.

Question 11

What is an example of a Cholesterol Absorption Inhibitor?

Answer 11

Ezetimibe

Ezetimibe is often used in combination with statins.

Question 12

What are Omega-3 Fatty Acid Ethyl Esters derived from?

Answer 12

Fish Oil

They contain essential fatty acids beneficial for heart health.

Question 13

Name the two main components of Omega-3 Fatty Acids.

Answer 13

• DHA (Docosahexaenoic acid)
• EPA (Eicosapentaenoic acid)

These components are known for their cardiovascular benefits.

Question 14

What is the mechanism of action for Lomitapide?

Answer 14

Microsomal Triglyceride Transfer Protein (MTP) Inhibitor

Lomitapide reduces the production of lipoproteins.

Question 15

What is Mipomersen used for?

Answer 15

Apolipoprotein B Antisense Oligonucleotide

Mipomersen is used to lower cholesterol levels in certain conditions.

Question 16

What is the function of Monoclonal Antibodies for PCSK9 Inhibition?

Answer 16

Lower LDL cholesterol levels

They work by inhibiting the PCSK9 protein which regulates LDL receptors.

Question 17

Name two Monoclonal Antibodies used for PCSK9 Inhibition.

Answer 17

• Evolocumab (Repatha)
• Alirocumab (Praluent)

These treatments are often used for patients with familial hypercholesterolemia.