Dylipidemia - Drug Thearpy COPY Flashcards
What are the major side effects of statins?
- myopathy
- increased liver enzymes
what are contraindications with statins?
- absolute: liver dz
- relative: use with certain drugs
What are demonstrated therapeutic benefits for statins?
- Reduce major coronary events
- reduce CHD mortality
- reduce coronary procedures (PTCA/CABG)
- reduce stroke
- reduce total mortality
What are the major actions against lipids of bile sequestrants?
- reduce LDL-C 15-30%
- raise HDL-C 3-5%
- may increase TG
What are the side effects of bile acid sequestrants?
- GI distress/constipation
- decreased absorption of other drugs
What are contraindications of bile acid sequestrants?
- dysbetalipoproteinemia
- raised TG (especially >400 mg/dL)
Which drugs are bile acid sequestrants?
- cholestyramine
- colestipol
- colesevelam
What are the demonstrated therapeutic benefits of bile acid sequestrants?
- reduce major coronary events
2. reduce CHD mortality
What are the major actions on lipids for nicotinic acid?
- lowers LDL-C 5-25%
- lowers TG 20-50%
- raises HDL-C 15-35%
What are the side effects of nicotinic acid?
- flushing
- hyperglycemia
- hyperuricemia
- upper GI distress
- hepatotoxicity
what are the contraindications of nicotinic acid?
- liver dz
- severe gout
- peptic ulcer
What are the demonstrated therapeutic benefits of nicotinic acid?
- reduces major coronary events
2. possible reduction in total mortality
What are the major actions on lipids of fibric acids?
- lower LDL-C 5-20% (with normal TG)
- may raise LDL-C (with high TG)
- lower TG 20-50%
- raise HDL-C 10-20%
what are the side effects of fibric acids?
- dyspepsia
- gallstones
- myopathy
What are the contraindications of fibric acids?
severe renal or hepatic disease
