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1PATHO > DSE OF IMMUNE PT2 > Flashcards

DSE OF IMMUNE PT2 Flashcards

1
Q

PERIPHERAL TOLERANCE IS SUPPRESSED BY

A

T REGULATORY CELLS

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2
Q

ALTERS NEGATIVE SELECTION

A

PTP22

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3
Q

IBD

CYTOPLASMIC SENSOR

A

NOD2

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4
Q

GROWTH N SURVIVAL OF TREG
MULTIPLE SCLE
TYPE 1 DM

A

IL2RA

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5
Q

SLE 65 UP

A

2:1

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6
Q

SLE CHILDBEARING

A

9:1

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7
Q

MALAR RASH
PHOTOSENSITIVE
BUTTERFLY RASH
FLAT

A

ACUTE LUPUS

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8
Q

DISCOID RASH
RAISED
SCALING

A

CHRONIC LUPUS

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9
Q

NONEROSIVE SYNOVITIS

A

JOINT DSE

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10
Q

PLEURITIS

A

SEROSITIS

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11
Q

PERSISTENT PROTEINURIA

>0.5 G/24

A

RENAL DISORDER

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12
Q

HALLMARK IS PROD OF AUTOANTIBODIES TO DOUBLE-STRANDED DNA

A

SMITH (SM) ANTIGEN

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13
Q

MOST SPECIFIC

CHROMATIN, HISTONES, DOUBLE STRANDED DNA

A

HOMOGENOUS OR DIFFUSE NUCLEAR STAINING

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14
Q

DOUBLE STRANDED DNA, NUCLEAR ENVELOPE

A

RIM OR PERIPHERAL

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15
Q

MOST COMMON
UNIFORM
LEAST SPECIFIC

A

SPECKLED

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16
Q

MOST DISTINCT

A

CENTROMERIC

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17
Q

AB TO RNA

A

NUCLEOLAR

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18
Q

RECURRENT SPONTANEOUS MISCARRIAGES

A

APS

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19
Q

VERY SUBTLE CHANGES

A

CLASS 1

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20
Q

MESANGIAL DEPOSITS GRANULAR APP

A

CLASS 2

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21
Q

<50

CRSCENT FORMATION

22
Q

> 50

WIRE LOOP

23
Q

THICKENING OF CAPILLARY WALL

24
Q

END-STAGE

>90%

25
Q

NONBACTERIAL VERRUCOUS ENDOCARDITIS

A

LIBMAN-SACKS

26
Q

FUNDAMENTAL IN SLE

A

FAILURE TO MAINTAIN SELF TOLERENCE

27
Q

LUPUS PX INHERITED DEFICIENCY

A

C2, C4, C1Q

28
Q 
WHAT DSE
BUTTERFLY RASH TRIGGERED BY SUNLIGHT
NON EROSIVE SYNOVITIS
NO INFLAM 
PLEURAL 
LIBMAN-SACKS
ONION SKIN SPLEEN
2NDARY PULMONARY HTN
29
Q

+ GENERIC ANAs

30
Q

+ ANTI-SSA, HLA-DR3

A

SUBACUTE LUPUS ERYTHEMATOUS

31
Q

INTERMEDIATE BET SLE N DISCOID

A

SUBACUTE LUPUS ERYTHEMATOUS

32
Q

+ ANTI-HISTONE BODIES

A

DRUG-INDUCED

33
Q 
CHRONIC
DRY EYES
DRY MOUTH
PRIMARY:SICCA SYNDROME
SECONDARY:RHEUNATOID
BLOCKAGE OF THE DUCTS
A

SJORGEN SYNDROME

34
Q

+ ANTI-SSA (RO)
+ ANT-SSB (La)
+ RHEUMATOID FACTOR

A

SJORGEN SYNDROME

35
Q

ENLARGEMENT OF THE SALIVARY AND LACRIMAL GLANDS

A

MICKULICZ SYNDROME

36
Q 
CHROIC INFLAM BY AUTOIMMUNITY
AUTIIMMUNE DSE
VASCULAR DAMAGE
COLLAGEN DEPOSITION FOR FIBROSIS
AUTOAMPUTATION
A

SCLERODERMA

37
Q

SCLERODERMA RATIO F:M

A

3:1

50-60 Y.O.

38
Q

DNA TOPO ISO 1 (ANTISCLERO 30-70) 10-20%
ANTI-CENTROMERE BODY (20-40) 30%
RNA POLYMERASE IIi(15-20)

A

SCLERODERMAA

39
Q

+ UI-RIBONUCLEOPROTEIN

A

MIXED CON TISSUE DSE

40
Q

+CCP

A

RHEUMATOID ARTHRITIS

41
Q

HISTIDYL

42
Q

REJECTION IS BY

A

T LYMPHOCYTE

43
Q

APC FROM DONOR/GRAFT
T CELL ACT BY MHC PROTEIN OF INTACT DONOR
T CELL MEDIATED ACUTE REJECTION

A

DIRECT ALLORECOGNITION

44
Q

CHRONIC REJECTION

RECIPIENT APC PICKED UP BY DONOR ANTIGEN AND PRESENT TO RECIPIENT TCELL

A

INDIRECT ALLORECOGNITION

45
Q

TYPE 1
CD4 N CD8 LYMPHOLYTIC INFLAM
EXPRESS MARKERS OF ACTIVATED T CELL

A

TUBULOINTERSTITIAL PATTERN

TUBULITIS

46
Q

ACUTE ANTIBODY MEDIATED REJECTION

A

B CELL MEDIATED

47
Q

ACUTE CELLULAR REJECTION

A

T CELL MEDIATED

48
Q

IMMUNOSUPPRESSIVE DRUG

NEPHROTXIC

A

CYCLOSPORINE

49
Q

HAVE INTERSTITIAL MONONUCLEAR INFILTRATES

WITH NK N PLASMA CELLS

A

CHRONICCALLY REJECTING KIDNEYS

50
Q

MANIFESTATION OF CHRONIC ANTIBODY MEDIATED REJECTION
INFLAMMATORY CELLS
ACCU OF MESANGIAL MATRIX
DUPLICATION OF CAPILLARY BASEMENT MEMBRANE

A

TRANSPLANT GLOMERULOPATHY

1PATHO (4 decks)

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