DSE OF IMMUNE PT2

Question 1

PERIPHERAL TOLERANCE IS SUPPRESSED BY

Answer 1

T REGULATORY CELLS

Question 2

ALTERS NEGATIVE SELECTION

Answer 2

PTP22

Question 3

IBD

CYTOPLASMIC SENSOR

Answer 3

NOD2

Question 4

GROWTH N SURVIVAL OF TREG
MULTIPLE SCLE
TYPE 1 DM

Answer 4

IL2RA

Question 5

SLE 65 UP

Answer 5

2:1

Question 6

SLE CHILDBEARING

Answer 6

9:1

Question 7

MALAR RASH
PHOTOSENSITIVE
BUTTERFLY RASH
FLAT

Answer 7

ACUTE LUPUS

Question 8

DISCOID RASH
RAISED
SCALING

Answer 8

CHRONIC LUPUS

Question 9

NONEROSIVE SYNOVITIS

Answer 9

JOINT DSE

Question 10

PLEURITIS

Answer 10

SEROSITIS

Question 11

PERSISTENT PROTEINURIA

>0.5 G/24

Answer 11

RENAL DISORDER

Question 12

HALLMARK IS PROD OF AUTOANTIBODIES TO DOUBLE-STRANDED DNA

Answer 12

SMITH (SM) ANTIGEN

Question 13

MOST SPECIFIC

CHROMATIN, HISTONES, DOUBLE STRANDED DNA

Answer 13

HOMOGENOUS OR DIFFUSE NUCLEAR STAINING

Question 14

DOUBLE STRANDED DNA, NUCLEAR ENVELOPE

Answer 14

RIM OR PERIPHERAL

Question 15

MOST COMMON
UNIFORM
LEAST SPECIFIC

Answer 15

SPECKLED

Question 16

MOST DISTINCT

Answer 16

CENTROMERIC

Question 17

AB TO RNA

Answer 17

NUCLEOLAR

Question 18

RECURRENT SPONTANEOUS MISCARRIAGES

Answer 18

APS

Question 19

VERY SUBTLE CHANGES

Answer 19

CLASS 1

Question 20

MESANGIAL DEPOSITS GRANULAR APP

Answer 20

CLASS 2

Question 21

<50

CRSCENT FORMATION

Answer 21

CLASS 3

Question 22

> 50

WIRE LOOP

Answer 22

CLASS 4

Question 23

THICKENING OF CAPILLARY WALL

Answer 23

CLASS 5

Question 24

END-STAGE

>90%

Answer 24

CLASS 6

Question 25

NONBACTERIAL VERRUCOUS ENDOCARDITIS

Answer 25

LIBMAN-SACKS

Question 26

FUNDAMENTAL IN SLE

Answer 26

FAILURE TO MAINTAIN SELF TOLERENCE

Question 27

LUPUS PX INHERITED DEFICIENCY

Answer 27

C2, C4, C1Q

Question 28

WHAT DSE
BUTTERFLY RASH TRIGGERED BY SUNLIGHT
NON EROSIVE SYNOVITIS
NO INFLAM 
PLEURAL 
LIBMAN-SACKS
ONION SKIN SPLEEN
2NDARY PULMONARY HTN

Answer 28

SLE

Question 29

+ GENERIC ANAs

Answer 29

SLE

Question 30

+ ANTI-SSA, HLA-DR3

Answer 30

SUBACUTE LUPUS ERYTHEMATOUS

Question 31

INTERMEDIATE BET SLE N DISCOID

Answer 31

SUBACUTE LUPUS ERYTHEMATOUS

Question 32

+ ANTI-HISTONE BODIES

Answer 32

DRUG-INDUCED

Question 33

CHRONIC
DRY EYES
DRY MOUTH
PRIMARY:SICCA SYNDROME
SECONDARY:RHEUNATOID
BLOCKAGE OF THE DUCTS

Answer 33

SJORGEN SYNDROME

Question 34

+ ANTI-SSA (RO)
+ ANT-SSB (La)
+ RHEUMATOID FACTOR

Answer 34

SJORGEN SYNDROME

Question 35

ENLARGEMENT OF THE SALIVARY AND LACRIMAL GLANDS

Answer 35

MICKULICZ SYNDROME

Question 36

CHROIC INFLAM BY AUTOIMMUNITY
AUTIIMMUNE DSE
VASCULAR DAMAGE
COLLAGEN DEPOSITION FOR FIBROSIS
AUTOAMPUTATION

Answer 36

SCLERODERMA

Question 37

SCLERODERMA RATIO F:M

Answer 37

3:1

50-60 Y.O.

Question 38

DNA TOPO ISO 1 (ANTISCLERO 30-70) 10-20%
ANTI-CENTROMERE BODY (20-40) 30%
RNA POLYMERASE IIi(15-20)

Answer 38

SCLERODERMAA

Question 39

+ UI-RIBONUCLEOPROTEIN

Answer 39

MIXED CON TISSUE DSE

Question 40

+CCP

Answer 40

RHEUMATOID ARTHRITIS

Question 41

HISTIDYL

Answer 41

MYOSITIS

Question 42

REJECTION IS BY

Answer 42

T LYMPHOCYTE

Question 43

APC FROM DONOR/GRAFT
T CELL ACT BY MHC PROTEIN OF INTACT DONOR
T CELL MEDIATED ACUTE REJECTION

Answer 43

DIRECT ALLORECOGNITION

Question 44

CHRONIC REJECTION

RECIPIENT APC PICKED UP BY DONOR ANTIGEN AND PRESENT TO RECIPIENT TCELL

Answer 44

INDIRECT ALLORECOGNITION

Question 45

TYPE 1
CD4 N CD8 LYMPHOLYTIC INFLAM
EXPRESS MARKERS OF ACTIVATED T CELL

Answer 45

TUBULOINTERSTITIAL PATTERN

TUBULITIS

Question 46

ACUTE ANTIBODY MEDIATED REJECTION

Answer 46

B CELL MEDIATED

Question 47

ACUTE CELLULAR REJECTION

Answer 47

T CELL MEDIATED

Question 48

IMMUNOSUPPRESSIVE DRUG

NEPHROTXIC

Answer 48

CYCLOSPORINE

Question 49

HAVE INTERSTITIAL MONONUCLEAR INFILTRATES

WITH NK N PLASMA CELLS

Answer 49

CHRONICCALLY REJECTING KIDNEYS

Question 50

MANIFESTATION OF CHRONIC ANTIBODY MEDIATED REJECTION
INFLAMMATORY CELLS
ACCU OF MESANGIAL MATRIX
DUPLICATION OF CAPILLARY BASEMENT MEMBRANE

Answer 50

TRANSPLANT GLOMERULOPATHY