DSA 1: Historical Review of OMM Research

Question 1

What is the AOA definition of OMM research?

Answer 1

Investigator states the relevance of proprosed project to osteopathic philosophy and principles, theories, mechanisms or practice

Question 2

Who was the pioneer career osteopathic researcher, serving as director of AT Still Research Institute and AOA researcher?

Answer 2

Dr. Louisa Burns

Question 3

What was Dr. Louisa Burns research in?

Answer 3

Viscerosomatic reflexes

Question 4

Who studied with Dr. Louisa Burns and reproduced/validated her experiments?

Answer 4

Dr. Wilbur Cole

Question 5

Who pioneered research in somatic dysfunctions/”osteopathic lesions”?

Answer 5

Dr. J.S. Denslow

Question 6

What did Dr. Denslow’s research consist of?

Answer 6

EMG/palpation correlation: documented spinal muscle reflex changes in areas of “osteopathic lesions”

Question 7

Which DO was an important proponent of standard terminology?

Answer 7

Dr. J.S. Denslow

Question 8

What did Dr. I.M. Korr’s research consist of?

Answer 8

Galvanic skin resistance as a result of disturbances in autonomic fxn in areas associated w/ palpatory findings and SD

Axoplasmic flow of nutrients and trophic fxn of nerves (movement of nutrients and ptns from cell body to cell body)

Question 9

Who did Dr. Korr study facilitation of spinal cord with?

Answer 9

Dr. Denslow

Question 10

What is sympathicotonia?

Answer 10

Heightened sympathetic tone

Increased autonomic outflow

(pathologic)

Question 11

Who was a big proponent of DO-patient interaction along with OMT as research paradigm?

Answer 11

Dr. I.M. Korr

Question 12

Who is referred to as the “Second Great philosopher of Osteopathic Medicine”?

Answer 12

Dr. I.M. Korr

Question 13

Korr took still’s ____ foundation and added ___ fxn to it.

Answer 13

Korr took still’s anatomical foundation and added physiological fxn to it.

Question 14

What type of research was Dr. William Johnston involved in?

Answer 14

Reliability studies

Validity studies

Viscerosomatic reflexes

Question 15

What were the MD vs DO mortality comparisons during the Spanish Influenza epidemic of 1918?

Answer 15

Overall mortality: MD - 5%, DO - 0.25%

Mortality w/ PNA complication: MD - 30-60%, DO - 10%

Question 16

What are the MD+DO vs DO only comparisons during 1932 at Unit II L.A. County Osteopathic Hospital?

Answer 16

Mortality: MD/DO - 9.7%, DO - 5.53%

Average Length of Stay (LOS): MD/DO - 16 days, DO - 9.7 days

Coroner’s cases: Both MD and DO - 14%

Question 17

In Dr. Anderson’s “A Comparison of Osteopathic Spinal Manipulation with Standard Care for Patients with Low Back Pain” in 1999, what were the subject criteria?

Answer 17

Backpain duration: At least 3 weeks, less than 6 mo

Age: 20-59

Standard care vs Osteopathic manipulation+standard care

Question 18

In Dr. Anderson’s “A Comparison of Osteopathic Spinal Manipulation with Standard Care for Patients with Low Back Pain” in 1999, what was the comparison of medications given for DOs and MDs?

Answer 18

OMT+PT+meds Significantly lower

• NSAIDS: 24%
• Muscle relaxers: 6%
• PT: 0.2%

MD+PT+Meds

• NSAIDS: 54%
• M. Relaxers: 25%
• PT: 2.6%

Question 19

In Dr. Anderson’s “A Comparison of Osteopathic Spinal Manipulation with Standard Care for Patients with Low Back Pain” in 1999, what were the outcomes of DO vs MD patients?

Answer 19

Outcomes were the sasme except the osteopathic group required less medication and PT (cheaper)

Question 20

In general, what are the outcomes for OMT in inflammatory disorders such as pancreatitis and ankle sprains?

Answer 20

Pancreatitis - Decreased LOS, analgesic use

Ankle sprain - decreased edema, pain, increased ROM

Question 21

In general, what are the outcomes for OMT in PNA?

Answer 21

Decreased LOS

Question 22

In general, what are the outcomes for OMT in pediatric otitis media?

Answer 22

Fewer surgical procedures

Higher avg surgery-free months

Increased frequency of normal tympanograms

Question 23

In general, what were the results of Dr. Lisa Hodge’s Dog Lab w/ Lymphatic Pump Treatment?

Answer 23

Increased flow of lymph in the thoracic duct

Increased # of circulating Leukocytes

Abdominal pump showed greater increase than thoracic pump

Question 24

In the Dog Lab With LPT, what cells have been measured increased in lymph?

Answer 24

Lymphocytes: CD4, CD8, IgA B cells IgG B cells

Neutrophils

Monocytes

Question 25

In lymphatic pump treatment, how long does it take go get maximum release of cells, cytokines, and proteins from the nodes?

Answer 25

2 minutes

Question 26

What substance influences contraction of lymph vessels? Stimulated by what?

Answer 26

NO, release stimulated by inflammation

Question 27

What were the 3 research groups of rats studied in LPT in disease states? What were they infected with?

Answer 27

Control - Under anesthesia

Sham Treatment - Light touch, anesthesia

LPT - Anesthesia

Streptococcus pneumoniae

Question 28

What were the results of LPT in disease states?

Answer 28

Control/sham groups: steady increase of bacterial in bronchial washings

LPT: steady decline of bacteria after 2-3 treatments , decreased immune cell concentration over time

Question 29

In LPT in diseased state, what cytokines/cells/serum markers showed no difference b/w control and treatment group?

Answer 29

Alveolar leukocytes, IL-1B, CRP, TNF-a, MCP-1, CBC

Question 30

What chemokines showed an increased concentration in LPT in diseased states? What does this support?

Answer 30

SP-D, IL-6, IL-17, IL-12, enhanced production of NO2 and IL-6 by alveolar macrophages

Supports clinical use of LPT in treating pneumococcal PNA

Question 31

What patient population can LPT help for immune function?

Answer 31

Pts that are immobile

Question 32

What were the results of the the LPT experiment that injected rats with tumor cells?

Answer 32

LPT group had decreased # of tumors

40% tumor reduction in lungs

Increase of every cell type in lungs (antitumor and NK cells)

Increased IL-2