Drugs with no target Flashcards
what is cromogliate?
a mast cell stabiliser
what does cromogliate do?
prevents degranulation and histamine release. It might also inhibit the release of pre-formed cytokines
what is the clinical use of cromoglicate?
Asthma (prophylaxis – although largely historical) Hay fever (eye drops),
what does simeticone do?
it is a drug with no target
- anti foaming agent
- decreases surface tension of gas bubbles, makes bigger bubbles - easier to pass wind
what does activated charcoal do?
its a WHO essential medicine to treat poisoning - binds poison to prevent absorption into GI tract
what do antacids do?
they’re alkaline ions (bicarbonate, Al(OH)3, Mg(OH)2) that neutralise acid in the stomach - reduces GI damage
what is the pharmacological significance of osmotic drugs?
they pharmacologically ineert
what are mannitol and isosorbide?
derivatives of glucose but not taken up into cells
is dextran who essential medicine?
yes
what do dextran, mannitol, and isorbide do?
increase osmolarity of blood and renal filtrate and do not enter cells
what are dextran also used in?
hypovolemic emergencies - to improve blood flow
paracetamol mechanism
not fully understood
when would you get paracetamol toxicity?
when glutathione (GSH) reserves are overwhelmed by N-acetyl-p-benzoquinoneimine (NAPQI)
what is the treatment for paracetamol toxicity?
N-acetylcysteine (NAC) given i.v. NAC acts as a sulfhydryl replacement and precursor for endogenous GSH synthesis
why is a receptor
the target molecules through which soluble physiological molecules produce their effects