drugs with narrow therapeutic index Flashcards
1
Q
what is narrow therapeutic index
A
Drugs where there is a small difference in the concentration of drug for efficacy and toxicity
2
Q
what is the NTI for phenytoin
A
10 - 20 mg/l
3
Q
what is the NTI for theophyline
A
10 - 20 mg/l
4
Q
what is the NTI for digoxin
A
0.7 - 2 mg/l
5
Q
what is the NTI for carbamazepine
A
4 - 12 mg/l
6
Q
what is the NTI for vancomycin
A
10 - 20 mg/l
7
Q
what is the NTI for Gentamicin
A
Peak standard: 5- 10 mg/l
Peak endocarditis - 3 - 5 mg/l
Trough (lowest) standard - 0.5 - 2 mg/l
Trough endocarditis - <1mg/ l
8
Q
what is the NTI for lithium
A
0.4 - 1 mmol/l
9
Q
what is the NTI for warfarin
A
2 - 3
