Drugs used to treat bleeding

Question 1

Aminocaproic acid class

Answer 1

t-PA inhibitor

Question 2

Aminocaproic acid description

Answer 2

synthetic inhibitor of fibrinolysis

Question 3

Aminocaproic acid mechanism

Answer 3

inhibits activation of plasminogen

Question 4

Aminocaproic acid indication

Answer 4

Hemophilia
Bleeding from fibrinolytic therapy
Aneurysm bleeding
Post-surgical GI bleed

Question 5

Aminocaproic acid adverse/contraindications

Answer 5

Intravascular thrombosis
HTN, myopathy
Abdominal discomfort, diarrhea
Nasal stuffiness
****DO NOT use in DIC or upper GI bleeding****

Question 6

Protamine sulfate class

Answer 6

antidote

Question 7

Protamine sulfate description

Answer 7

chemical antagonist binds heparin rendering it inactive (lots of arginine gives it a strong +ve charge)

Question 8

Protamine sulfate indication

Answer 8

Heparin toxicity (UFH)
Not effect against fondaparinux

Question 9

Protamine sulfate adverse

Answer 9

Coagulation if no heparin

Hypersensitivity -> dyspnea, flushing, bradycardia, hypotension

Question 10

Vitamin K class

Answer 10

Antidote

Question 11

Vitamin K description

Answer 11

Carboxylates clotting factors
Response is complete in 24 hrs, onset in 6
FFP used for immediate hemostasis

Question 12

Vitamin K Indication

Answer 12

Stops bleeding induced by oral anti-coagulation (Warfarin)

Hypoprothrominemia in babies

Question 13

Plasma fractions description

Answer 13

replaces coagulation factors that are dificent in genetic disorders

Question 14

Plasma fractions indication

Answer 14

Hemophilia A -> PF-8

Christmas disease -> PF-9