Drugs used in Immune Diseases - Ciclosporin

Question 1

What is the MOA Cicloporin?

Answer 1

Binds to cyclophilin, CsA specific competitive –| of calcineurin Ca2+ & calmodulin-dependent phosphates.

Question 2

What are the indications of Cliclosporin?

Answer 2

IBS
Immunosuppresive therapy in transplant Pt
Psoriasis
Severe atopic dermatitis
RA

Question 3

What are the S/E of cicloporin?

Answer 3

Common:
Headache, Tremor, Hypotension, Hirsutism, renal impairment.
Other S/E:
Immunosuppresion increases risk of infections.

Question 4

What are the contra-indications of cicloporin?

Answer 4

Abnormal baseline renal functions
Malignancy
Uncontrolled hypertension
Uncontrolled infection

Question 5

What are the monitorin of ciclosporin?

Answer 5

Renal function
Hepatic Function
Blood pressure
Lipids
Electrolytes - Pottassium, Magnesium
Uric Acid

Question 6

What interactions does ciclosporin have?

Answer 6

CYP450 –| : Macrolides, diltiazem, verapamil, lercidapine, fluconazole -> increase blood ciclosporin lvls.
CYP450 Inducers - Rifampicin, carbamezepine, phenobarbital, phenytoin, st jhons wort -> decrease blood cicloproin lvls.
Statins

Question 7

What are the differences between IV & oral preperations of cicloporin?

Answer 7

Oral doses is approximatley 3x that of the IV formulation