Drugs used in Diabetes !!!!

Question 1

Side effects of insulin?

Answer 1

• Hypoglycaemia
• Weight gain
• Lipodystrophy

Question 2

Side effects of metformin?

Answer 2

• GI upset

- Lactic acidosis

Question 3

MoA of metformin?

Answer 3

Increases insulin sensitivity

Decreases hepatic gluconeogenesis

Question 4

When can metformin NOT be used?

Answer 4

In patients with an eGFR of < 30ml/min

Question 5

MoA of sulphonylureas?

Answer 5

Stimulate pancreatic beta cells to secrete insulin

Question 6

Side effects of Sulphonylureas?

Answer 6

• weight gain
• hypoglycaemia
• hyponatraemia

Question 7

Name 2 sulphonylureas

Answer 7

Gliclazide

Glimepiride

Question 8

Name the only TZD available?

Answer 8

Pioglitazone

Question 9

MoA of TZDs?

Answer 9

Activate PPAR-gamma receptor in adipocytes to promote adipogenesis and fatty acid uptake

Question 10

side effects of TZDs?

Answer 10

• weight gain

- fluid retention

Question 11

MoA of DPP4-inhibitors?

Answer 11

Increase incretin levels which inhibit glucagon secretion

sitagliptin

Question 12

Name an SGLT-2 inhibitor?

Answer 12

Dapagliflozin

Question 13

side effects of SGLT-2 inhibitors?

Answer 13

• UTI (thrush)

- weight loss

Question 14

MoA of SGLT-2 inhibitors?

Answer 14

Inhibit reabsorption of glucose in the kidney

Question 15

side effects of GLP-1 agonists?

Answer 15

• vomiting
• nausea
• pancreatitis
• weight loss

Question 16

MoA of GLP-1 agonists?

Answer 16

Incretin mimetic which inhibits glucagon secretion