Drugs Used in Bone and Mineral Disorders

Question 1

Name the bisphonates and what is a common suffix for this class of drugs?

Answer 1

“dronate”

alendronate
pamidronate

Question 2

MOA bisphosphonates.

Answer 2

Dir. inhibit bone resorption by inhibiting enzyme farnesyl pyrophosphate synthase (FPP)

• inhibition of FPP synthase disrupts proteins which are responsible for maintaining cytoskeletal integrity of osteoclast

*osteoclast detachment is promoted > reduced bone resorption

Question 3

Indications bisphosphonates?

Answer 3

1st line for osteoporoses

Pagets disease

Question 4

S/E of bisophosphonates.

Answer 4

bone mineralization defects (etidronate and pamidronate)

GI distress including esophageal ulcers (alendronate)

Question 5

Consideration when taking bisphosphantes to avoid GI issues and esophageal ulcers?

Answer 5

Take upright and don’t take food for about 30 minutes after taking drug

Question 6

MOA teriparatide?

Answer 6

recombinant DNA PTH analog

Question 7

Indications teriparatide.

Answer 7

1X daily to stimulate osteoblasts and new bone formation

Question 8

S/E of teriparatide use?

Answer 8

Risk of osteosarcoma which is increases if taken more than 2 years

Question 9

MOA denosumab.

Answer 9

inhibits RANK ligand, a protein which acts as the primary signal for bone removal