drugs to treate Pulm TB Flashcards
what are the 4 drugs for Tuberculosis
R: Rifampin
I: Isoniazid
P: Pyrazinamide
E: Ethambutol
Rifampin Indications and Contraindictions
Indications: treatment of both tuberculosis and meningococcal carriers
Contraindictions:
- hypersensitivity
- patients recieving saquinavir due to hepatocellular toxicity
- patients recieving other anti viral drugs
Warnings precautions and drug interactions of Rifampin
Warnings:
-Liver dysfunctions (jaundice)
Precautions:
-Caution in diabetes mellitus
Drug interactions:
-induce cP450
Adverse effects:
- GI
- Hema
- Hepatic
- CNS
- Ocular
- Endocrine
- Renal
Isoniazid MOA, Indications
MOA:
-inhibits the synthesis of mycoloic acids of the bacterial cell wall
Idication:
-all forms of tuberculosis
Isoniazid Contraindictions and Black box warning
Contraindictions:
- hypersensitivity
- hepatitis
- hepatic isusses
Black box warning:
-severe and fatal hepatitis can be associated after use
adverse reactions:
-Nervous system and the liver
Drug interactions of Isoniazid
Food acetaminophen carbamazepine valproate Theophylline
Pyrazinamide Indications and contradictions
initial treatment of active tuberculosis with other antituberculous agents
Contraindications:
- severe hepatic damage
- hypersensitivity
- acute gout
warnings and adverse effects of Pyrazinamide
Warnings:
- hepatitis
- hyperurcemia
Adverse reactions:
- general
- prophyria, dysuria
- diabetes mellitus
MOA and indications of Ethambutol
oral chemotherapeutic agent that is effective against Mycobacterium including tuberculosis
Indications:
- Pulmonary tuberculosis
- needs to be used with other anti tuberculosis drugs
Contraindictions, warnings, precautions for Ethambutol
contraindictions:
- hypersensitivity
- optic neuritits
- report visual side effects or changes of vision
Warnings
-decreases visual acuity which appear to be due to optic neuritis
Precautions
-not recomended in patients below 13`
Streptomycin indications
Treatment of mycobacterium tuberculosis
can be sueful for many other organisms
Streptomycin warnings and black box warnings
warnings: ototoxicity both vestibular and auditory
Black box warning:
-neurotoxic reactions in patients with impaired renal function
