Drugs to Treat Pulmonary TB

Question 1

What are first line agents for treatment of active TB?

Answer 1

RIPE(S):

1) Rifampin
2) Isoniazid
3) Pyrazinamide
4) Ethambutol
5) Sometimes streptomycin

Question 2

Rifampin has been shown to produce what toxicity?

Answer 2

Liver dysfunction

Question 3

What drug interaction does rifampin have with certain cytochrome P450 enzymes?

Answer 3

Inducer, so may accelerate elimination of co-administered drugs

Question 4

What essential component of the bacterial cell wall does isoniazid inhibit the synthesis of?

Answer 4

Mycolic acids

Question 5

What black box warning does isoniazid have?

Answer 5

Fatal hepatitis

Question 6

What contraindications does pyrazinamide have?

Answer 6

1) Patients with severe hepatic damage

2) Patients with acute gout

Question 7

What contraindications does ethambutol have?

Answer 7

In patients who report visual side effects or changes in vision

Question 8

Prescribing what drug in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria?

Answer 8

Streptomycin

Question 9

What warning is associated with streptomycin?

Answer 9

Ototoxicity