Drugs to treat cardiac arrhythmias Flashcards

1
Q

Target of class 1 antiarrhythmics

A

Myocardial AP

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2
Q

What drugs fall under the class 1A antiarrhythmics?

A

Procainamide

Quinidine

Disopyramide

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3
Q

What effects to the class 1A drugs have on the myocardial AP?

A

Block Na+ channels leading to widened QRS

Block K+ channels leading to prolonged AP and thus a prolonged QT on ECG

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4
Q

What type of arrhythmias do class 1A drugs treat?

A

SVT

VT

Arryhthmias associated with MI (not first line)

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5
Q

What drugs fall under the class 1B antiarrhythmics?

A

Lidocaine

Mexiletine

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6
Q

What effects to the class 1B drugs have on the myocardial AP?

A

Block Na+ channels thus decrease the slope of phase ) and widen QRS on ECG

Do not bind to K+ channels, thus do not prolong AP. The AP is actually shortened

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7
Q

What drugs fall under the class 1C antiarrhythmics?

A

Flecainide

Propafenone

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8
Q

What effects to the class 1C drugs have on the myocardial AP?

A

Block Na+ channel thus decrease slope of phase 0 and widen QRS on ECG

Block certain K+ channels, but not ones that repolarize the AP, thus AP length is not changed

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9
Q

What type of arrhythmias do class 1C drugs treat?

A

SVT in patients with normal hearts

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10
Q

What type of arrhythmias do class 1B drugs treat?

A

VT in the setting of MI

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11
Q

Class 2 drugs used in treating arrhythmias are?

A

Beta-blockers (esmolol, propranolol)

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12
Q

Target of Class 2 antiarrhythmics

A

Pacemaker AP

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13
Q

Class 3 antiarrhythmics MOA

A

Block K+ channels thus prolong the AP duration and inducing prolonged QT on EKG.

They prolong the refractory period

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14
Q

What drugs fall under the class 3 antiarrhythmics?

A

Amiodarone

Sotalol (Beta-blocker)

Dofetilide

Ibutilide

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15
Q

Class 4 antiarrhythmic drug MOA and target

A

Cardioactive calcium channel blockers

Target the SA node

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16
Q

Effects of class 4 antiarrhythmics

A

Prolonged AP thus prolonged QT on EKG

Prolonged conduction time at the AV node

17
Q

Adenosine is a miscellaneous drugs used to treat SVT, what is the MOA?

A

Activation of K+ channels and inhibition of Ca+ and funny Na+ channels causing marked hyperpolarization and suppression of AP.

Inhibits AV conduction and increases the nodal refractory period