Drugs to Treat ANCA Vasculitis (Iszard) Flashcards

1
Q

Interstitial Nephritis which may be seen with ANCA-associated vasculitis when the vasculitis involves the renal medulla, is treated with?

A

Glucocorticoids

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2
Q

What are some patient population in which systemic glucocorticoid administration is problematic?

A

1) Immunocompromised patients (HIV/AIDS)
2) Diabetics
3) Patients with active infections

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3
Q

What is an alkylating drug used to treat ANCA vasculitis and Goodpasture’s syndrome?

A

Cyclophosphamide

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4
Q

Cyclophosphamide is indicated to treat what condition in pediatric patients?

A

Minimal Change Nephrotic Syndrome

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5
Q

What limitation of use does cyclophosphamide have?

A

Treatment of nephrotic syndrome or other renal disease in adults

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6
Q

Cyclophosphamide is contraindicated in patients with?

A

Urinary outflow obstruction

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7
Q

What is a CD20-directed cytolytic antibody used to treat ANCA vasculitis and Goodpasture’s syndrome?

A

Rituximab

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8
Q

Rituximab is not recommended for use in patients with?

A

Severe active infections

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9
Q

What black box warning is associated with rituximab?

A

1) Fatal infusion reactions
2) Tumor lysis syndrome
3) Severe mucocutaneous reactions
4) Progressive multifocal leukoencephalopathy (PML)

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10
Q

Renal toxicity may result from a drug interaction between Rituximab and?

A

Cisplatin

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11
Q

What is an adjunct for the prevention of rejection in renal homotransplantation and in the management of rheumatoid arthritis?

A

Azathioprine

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12
Q

Post-transplant Renal transplant patients are known to have an increased risk of malignancy, predominantly?

A

Skin cancer

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13
Q

The risk of post-transplant lymphomas may be increased in patients who receive aggressive treatment with?

A

Immunosuppressive drugs, including Azathioprine

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14
Q

All immunosuppressive drug therapy should be maintained at?

A

Lowest effective levels

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