Drugs To Know FINAL Flashcards
Aspirin
COX 1+2 inhibitor NSAID
Irreversibly inhibits platelet aggregation so used in low doses after MI/CVA
- anti-inflammatory
- anti-pyretic
- analgesic
Aspirin SE
Gastric discomfort
Acute nephritis
Reye’s syndrome in kids
CV shock in patients with hypersensitivity
May prolong healing
Ibuprofen
COX 1+2 inhibitor
Non aspirin NSAID
Similar pain and anti-inflammatory effects as aspirin
Ibuprofen SE
GI side effects
Naproxen
COX1+2 inhibitor NSAID
Similar to ibuprofen in pain relief but longer lasting
Naproxen SE
GI shit
Indomethacin
More potent NSAID COX 1+2 inhibitor
Useful for RA and heterotopic ossificans
Indomethacin SE
GI distress
Ketorolac
COX 1+2 INhibitor NSAID
Most potent and efficacious
Best pain relief — equivalent to some mild to moderate opioids
Ketorolac SE
GI distress
Celecobix
COX 2 inhibitor
Similar anti-pyretic, anti-inflammatory, analgesic effects but not as many GI issues
Good for OA and RA
Celecobix SE
CV issues - may increase clotting and HTN
Rofecoxib and Valdeloxib
Off the market COX 2 inhibitors
Diclofenac
COX 1+2 inhibitor
More potent than ibuprofen and naproxen but not as efficacious as ketorolac
Diclofenac SE
GI discomfort
Acetaminophen
Tylenol!
Analgesic and anti-pyretic effects but NO anti-inflammatory or anti-coagulant effects
Better for long term pain relief
Acetaminophen SE
Not associated with GI irritation, reye’s, or toxicity
Can be toxic to liver
Methotrexate
DMARD - Immunosuppressant
Impairs DNA/RNA synthesis
Effective and rapid acting
For RA and cancer in higher doses
Methotrexate SE
GI disturbance
N+V
Loss of appetite
Pulmonary/liver/blood disorders
Hair loss
if taken with leucovirin/folinic acid can decrease the amount of side effects
Azathioprine
DMARD - immunosuppressant
Impairs DNA.RNA synthesis
Effective for RA but toxic
Penicillamine
DMARD — immunosuppressant
Moderately toxic
Hydroxychloroquine
DMARD - immunosuppressant that blocks action of T cells
Not very effective
Hyaluronin
Viscosupplementation to change consistency of synovial fluid in joints with OA — specifically increases synovial fluid consistency and limits the progression of erosion
Glucosamine and Chondriotin sulfate
Oral medications for OA but not FDA regulated
