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Pharmacology > Drugs To Know FINAL > Flashcards

Drugs To Know FINAL Flashcards

1
Q

Aspirin

A

COX 1+2 inhibitor NSAID
Irreversibly inhibits platelet aggregation so used in low doses after MI/CVA
- anti-inflammatory
- anti-pyretic
- analgesic

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2
Q

Aspirin SE

A

Gastric discomfort
Acute nephritis
Reye’s syndrome in kids
CV shock in patients with hypersensitivity
May prolong healing

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3
Q

Ibuprofen

A

COX 1+2 inhibitor
Non aspirin NSAID
Similar pain and anti-inflammatory effects as aspirin

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4
Q

Ibuprofen SE

A

GI side effects

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5
Q

Naproxen

A

COX1+2 inhibitor NSAID
Similar to ibuprofen in pain relief but longer lasting

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6
Q

Naproxen SE

A

GI shit

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7
Q

Indomethacin

A

More potent NSAID COX 1+2 inhibitor
Useful for RA and heterotopic ossificans

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8
Q

Indomethacin SE

A

GI distress

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9
Q

Ketorolac

A

COX 1+2 INhibitor NSAID
Most potent and efficacious
Best pain relief — equivalent to some mild to moderate opioids

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10
Q

Ketorolac SE

A

GI distress

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11
Q

Celecobix

A

COX 2 inhibitor
Similar anti-pyretic, anti-inflammatory, analgesic effects but not as many GI issues
Good for OA and RA

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12
Q

Celecobix SE

A

CV issues - may increase clotting and HTN

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13
Q

Rofecoxib and Valdeloxib

A

Off the market COX 2 inhibitors

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14
Q

Diclofenac

A

COX 1+2 inhibitor
More potent than ibuprofen and naproxen but not as efficacious as ketorolac

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15
Q

Diclofenac SE

A

GI discomfort

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16
Q

Acetaminophen

A

Tylenol!
Analgesic and anti-pyretic effects but NO anti-inflammatory or anti-coagulant effects
Better for long term pain relief

17
Q

Acetaminophen SE

A

Not associated with GI irritation, reye’s, or toxicity
Can be toxic to liver

18
Q

Methotrexate

A

DMARD - Immunosuppressant
Impairs DNA/RNA synthesis
Effective and rapid acting
For RA and cancer in higher doses

19
Q

Methotrexate SE

A

GI disturbance
N+V
Loss of appetite
Pulmonary/liver/blood disorders
Hair loss
if taken with leucovirin/folinic acid can decrease the amount of side effects

20
Q

Azathioprine

A

DMARD - immunosuppressant
Impairs DNA.RNA synthesis
Effective for RA but toxic

21
Q

Penicillamine

A

DMARD — immunosuppressant
Moderately toxic

22
Q

Hydroxychloroquine

A

DMARD - immunosuppressant that blocks action of T cells
Not very effective

23
Q

Hyaluronin

A

Viscosupplementation to change consistency of synovial fluid in joints with OA — specifically increases synovial fluid consistency and limits the progression of erosion

24
Q

Glucosamine and Chondriotin sulfate

A

Oral medications for OA but not FDA regulated

25
Q

Cyclobenzaprine

A

Muscle relaxer. General CNS relaxer with no specific effects on alpha motor neuron
Used as adjunctive treatment with rest and PT

26
Q

Cyclobenzaprine SE

A

Drowsiness
Dizziness
Headache
N+V

27
Q

Methocarbamol

A

Muscle relaxer. General CNS replacer with no specific effect on alpha motor neurons

28
Q

Methocarbamol SE

A

Drowsiness
Dizziness
Headache
N+V

29
Q

Diazepam

A

Benzodiazepine - stimulates GABA on SC
Indicated for MSK injuries
Anti-spasm and anti-spasticity

30
Q

Diazepam SE

A

Anterograde memory loss

31
Q

Gabapentin

A

2nd generation anti-epileptic
Not very effective when used alone
Increases inhibitory effect of GABA

32
Q

Gabapentin SE

A

Drowsiness/sedation
Ataxia and dizziness
Anterograde memory loss
But all much milder

33
Q

Amobarbital

A

barbiturates

34
Q

Amobarbital SE

A
35
Q

Secobarbital

A

barbiturates

36
Q

Secobarbital SE

A
37
Q

Phenobarbital

A

barbiturates
Given for most seizure but best for grand mal
Increases inhibitory effects of GABA

38
Q

Phenobarbital SE

A

Sedation
Ataxia
Nystagmus
Folate and vitamin K deficiency
may paradoxically increase seizures and hyperactivity in children

Pharmacology (4 decks)

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