Drugs to Know 3 Flashcards

1
Q

Antacids

A

Preanesthetic Medication

facilitate smooth induction of anesthesia

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2
Q

Anticholinergics

A

Preanesthetic Medication

facilitate smooth induction of anesthesia;
prevent bradycardia and secretion of fluids into the respiratory tract

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3
Q

Antiemetics

A

Preanesthetic Medication

facilitate smooth induction of anesthesia;
prevent nausea and possible aspiration of stomach contents

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4
Q

Antihistamines

A

Preanesthetic Medication

facilitate smooth induction of anesthesia;
prevention of allergic reactions

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5
Q

Benzodiazepines

A

Preanesthetic Medication; General Anesthetic: IV

facilitate smooth induction of anesthesia

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6
Q

Opioids

A

Preanesthetic Medication

facilitate smooth induction of anesthesia

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7
Q

Desflurane

A

General Anesthetic: Inhaled

no specific receptor; interactions with proteins comprising ion channels; some facilitate GABA mediated inhibition and others antagonize the excitatory action of glutamic acid

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8
Q

Isoflurane

A

General Anesthetic: Inhaled

no specific receptor; interactions with proteins comprising ion channels; some facilitate GABA mediated inhibition and others antagonize the excitatory action of glutamic acid

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9
Q

Nitrous Oxide

A

General Anesthetic: Inhaled

no specific receptor; interactions with proteins comprising ion channels; some facilitate GABA mediated inhibition and others antagonize the excitatory action of glutamic acid

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10
Q

Sevoflurane

A

General Anesthetic: Inhaled

no specific receptor; interactions with proteins comprising ion channels; some facilitate GABA mediated inhibition and others antagonize the excitatory action of glutamic acid

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11
Q

Barbiturates

A

General Anesthetic: Intravenous

exact mechanism of action unknown; thought to be similar to inhaled

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12
Q

Etomidate

A

General Anesthetic: Intravenous

exact mechanism of action unknown; thought to be similar to inhaled

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13
Q

Ketamine

A

General Anesthetic: Intravenous

exact mechanism of action unknown; thought to be similar to inhaled

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14
Q

Opioids

A

General Anesthetic: Intravenous

exact mechanism of action unknown; thought to be similar to inhaled

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15
Q

Propofol

A

General Anesthetic: Intravenous

exact mechanism of action unknown; thought to be similar to inhaled

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16
Q

Benoxinate

A

Local Anesthetic: Topical

bind to a location on the Na channel; alters depolarization (blocks channel); increase recovery time; primarily used to block information about painful stimuli from the point of stimulus to the spinal column

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17
Q

Cocaine

A

Local Anesthetic: Topical

bind to a location on the Na channel; alters depolarization (blocks channel); increase recovery time; primarily used to block information about painful stimuli from the point of stimulus to the spinal column

also has alpha adrenergic agonist activity; causes vasoconstriction

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18
Q

Lidocaine

A

Local Anesthetic: Topical

bind to a location on the Na channel; alters depolarization (blocks channel); increase recovery time; primarily used to block information about painful stimuli from the point of stimulus to the spinal column

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19
Q

Proparacaine

A

Local Anesthetic: Topical

bind to a location on the Na channel; alters depolarization (blocks channel); increase recovery time; primarily used to block information about painful stimuli from the point of stimulus to the spinal column

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20
Q

Tetracaine

A

Local Anesthetic: Topical

bind to a location on the Na channel; alters depolarization (blocks channel); increase recovery time; primarily used to block information about painful stimuli from the point of stimulus to the spinal column

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21
Q

Articaine

A

Local Anesthetic: Injection

bind to a location on the Na channel; alters depolarization (blocks channel); increase recovery time; primarily used to block information about painful stimuli from the point of stimulus to the spinal column

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22
Q

Bupivicaine

A

Local Anesthetic: Injection

bind to a location on the Na channel; alters depolarization (blocks channel); increase recovery time; primarily used to block information about painful stimuli from the point of stimulus to the spinal column

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23
Q

Mepivicaine

A

Local Anesthetic: Injection

bind to a location on the Na channel; alters depolarization (blocks channel); increase recovery time; primarily used to block information about painful stimuli from the point of stimulus to the spinal column

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24
Q

Procaine

A

Local Anesthetic: Injection

bind to a location on the Na channel; alters depolarization (blocks channel); increase recovery time; primarily used to block information about painful stimuli from the point of stimulus to the spinal column

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25
Succinylcholine
Neuromuscular Blocker produce muscle paralysis; lack CNS activity; depolarizing agent - reacts with nicotinic receptor to open the ion channel and cause depolarization; muscle fibers remain depolarized because succinlycholine is not metabolized at the synapse; flaccid paralysis results because the muscle fibers can't repolarize (phase I block)
26
Cisatracurium
Neuromuscular Blocker produce muscle paralysis; lack CNS activity; non-depolarizing agent - competes with acetylcholine for binding site; will also enter and block the ion channel at high doses
27
Rocuronium
Neuromuscular Blocker produce muscle paralysis; lack CNS activity; non-depolarizing agent - competes with acetylcholine for binding site; will also enter and block the ion channel at high doses
28
Vecuronium
Neuromuscular Blocker produce muscle paralysis; lack CNS activity; non-depolarizing agent - competes with acetylcholine for binding site; will also enter and block the ion channel at high doses
29
Baclofen
Centrally Acting Spasmolytic Drug reduce spasticity and muscle spasms; CNS depressant; interrupt neuronal communication resulting in sedation and alteration of pain perception *main effect at GABA receptors; inhibits spinal reflexes
30
Carisoprodol
Centrally Acting Spasmolytic Drug reduce spasticity and muscle spasms; CNS depressant; interrupt neuronal communication resulting in sedation and alteration of pain perception *interrupts neuronal communication; produces sedation and altered pain perception
31
Cyclobenzaprine
Centrally Acting Spasmolytic Drug reduce spasticity and muscle spasms; CNS depressant; interrupt neuronal communication resulting in sedation and alteration of pain perception *main effect at NE and 5HT receptors; increases transmission
32
Tizanidine
Centrally Acting Spasmolytic Drug reduce spasticity and muscle spasms; CNS depressant; interrupt neuronal communication resulting in sedation and alteration of pain perception *main effect at alpha-2 receptors; increase pre-synaptic motor neuron inhibition
33
Gabapentin
Centrally Acting Spasmolytic Drug reduce spasticity and muscle spasms; CNS depressant; interrupt neuronal communication resulting in sedation and alteration of pain perception *thought to bind to a carrier protein at a unique receptor; results in elevated GABA levels in the brain
34
Dantrolene
Direct Acting Muscle Relaxant reduces skeletal muscle strength by interfering with excitation-contraction coupling in the muscle fibers; prevents release of calcium by blocking the channel in the sarcoplasmic reticulum; decreases intracellular calcium
35
Adrenocortioctropic Hormone (ACTH)
Anterior Pituitary Hormone produced when stimulated by corticotropin hormone; ACTH binds to receptors in the adrenal cortex; stimulates the release of adrenocortiosteroids and adrenal androgens
36
Growth Hormone (GH)
Anterior Pituitary Hormone released in response to growth hormone releasing hormone; secretion decreases with age; promotes cell proliferation, bone growth, cartilage synthesis, and others; synthetic GH is used to treat growth failure in children
37
Luteinizing Hormone (LH)
Anterior Pituitary Hormone- Gonadotropin regulates gonadal steroid hormones
38
Follicle Stimulating Hormone (FSH)
Anterior Pituitary Hormone- Gonadotropin regulates gonadal steroid hormones
39
Prolactin (PRL)
Anterior Pituitary Hormone similar in structure to GH; secretion is inhibited by dopamine; primary function is to stimulate and maintain lactation; also involved in reproductive function and immune function
40
Thyroid Stimulating Hormone
Anterior Pituitary Hormone
41
Growth Hormone Releasing Hormone
Hypothalamus Hormone
42
Growth Hormone Inhibiting Hormone
Hypothalamus Hormone suppress GH and thyroid-stimulating hormone release; also inhibits release of insulin, glucagon, and gastrin
43
Gonadotropin Releasing Hormone (GnRH)
Hypothalamus Hormone essential for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary; must be pulse dose- continuous dose actually inhibits release; synthetic GnRH can be used to suppress production of gonadal hormones; administered continuously
44
Corticotropin Releasing Hormone
Hypothalamus Hormone
45
Thyrotropin Releasing Hormone
Hypothalamus Hormone
46
Oxytocin
Hormone of the Posterior Pituitary hypothalamus synthesizes the precursors; transported to posterior pituitary and stored; stimulates uterine contraction and milk injection; used clinically to induce labor
47
Vasopressin/ADH
Hormone of the Posterior Pituitary hypothalamus synthesizes the precursors; transported to posterior pituitary and stored; increases water permeability and reabsorption in the kidney; used clinically to treat diabetes insipidus; also causes constriction of vascular smooth muscle
48
Iodine and potassium iodide
Drug Affecting the Thyroid inhibits the production of hormone; mechanism not known
49
Liothyronine
Drug Affecting the Thyroid treatment of hypothyroidism
50
Levothyroxine
Drug Affecting the Thyroid treatment of hypothyroidism
51
Methimazole
Drug Affecting the Thyroid inhibition of thyroid hormone synthesis; inhibit step in production of hormone; have no effect on hormone already stored; may cause delay in effect
52
Propylthiouracil
Drug Affecting the Thyroid inhibition of thyroid synthesis; inhibit step in production of hormone; have no effect on hormone already stored; may cause delay in effect
53
Estradiol
Estrogen steroid hormones diffuse across cell membrane and bind to estrogen receptors; activated complex interacts with nuclear chromatin to initiate RNA synthesis most potent estrogen produced by the ovary; principal estrogen in the premenopausal woman
54
Estrone
Estrogen steroid hormones diffuse across cell membrane and bind to estrogen receptors; activated complex interacts with nuclear chromatin to initiate RNA synthesis metabolite of estradiol also produced by the ovary; primary circulating estrogen after menopause
55
Estriol
Estrogen steroid hormones diffuse across cell membrane and bind to estrogen receptors; activated complex interacts with nuclear chromatin to initiate RNA synthesis metabolite of estradiol; produced by the placenta; present in significant amounts during pregnancy
56
Leuprolide
GnRH Analog pulse dose causes an increase in the production of FSH and LH; males- stimulate spermatogenesis and testosterone production; females- induce ovulation or treat primary hypothalamic amenorrhea; chronic administration leads to a decrease in production of FSH and LH; due to a decrease in receptor density; males- treatment of advanced prostate cancer and prostatic hyperplasia; females- treatment of endometriosis, polycystic ovary disease, and other uterine disorders
57
Gonadorelin
GnRH Analog pulse dose causes an increase in the production of FSH and LH; males- stimulate spermatogenesis and testosterone production; females- induce ovulation or treat primary hypothalamic amenorrhea; chronic administration leads to a decrease in production of FSH and LH; due to a decrease in receptor density; males- treatment of advanced prostate cancer and prostatic hyperplasia; females- treatment of endometriosis, polycystic ovary disease, and other uterine disorders
58
Nafarelin
GnRH Analog pulse dose causes an increase in the production of FSH and LH; males- stimulate spermatogenesis and testosterone production; females- induce ovulation or treat primary hypothalamic amenorrhea; chronic administration leads to a decrease in production of FSH and LH; due to a decrease in receptor density; males- treatment of advanced prostate cancer and prostatic hyperplasia; females- treatment of endometriosis, polycystic ovary disease, and other uterine disorders
59
Raloxifene
Selective Estrogen-Receptor Modulator interact at estrogen receptors; compete with estrogen for binding in breast tissue; causes regression of some breast tumors; decreases bone resorption and overall bone turnover; little effect on endometrium; lower risk of uterine cancer
60
Tamoxifen
Selective Estrogen-Receptor Modulator interact at estrogen receptors; compete with estrogen for binding in breast tissue; causes regression of some breast tumors; decreases bone resorption and overall bone turnover; little effect on endometrium; lower risk of uterine cancer
61
Clomiphene
Selective Estrogen-Receptor Modulator interact at estrogen receptors;
62
Drospirenone
Progestogen produced in response to LH in both males and females; in females, promotes development of secretory endometrium; accommodates implantation of embryo; continues to be secreted if conception takes place
63
Levonorgestrel
Progestogen produced in response to LH in both males and females; in females, promotes development of secretory endometrium; accommodates implantation of embryo; continues to be secreted if conception takes place
64
Medroxyprogesterone
Progestogen produced in response to LH in both males and females; in females, promotes development of secretory endometrium; accommodates implantation of embryo; continues to be secreted if conception takes place
65
Megestrol
Progestogen produced in response to LH in both males and females; in females, promotes development of secretory endometrium; accommodates implantation of embryo; continues to be secreted if conception takes place
66
Norelgestromin
Progestogen produced in response to LH in both males and females; in females, promotes development of secretory endometrium; accommodates implantation of embryo; continues to be secreted if conception takes place
67
Norethindrone
Progestogen produced in response to LH in both males and females; in females, promotes development of secretory endometrium; accommodates implantation of embryo; continues to be secreted if conception takes place
68
Preogesterone
Progestogen produced in response to LH in both males and females; in females, promotes development of secretory endometrium; accommodates implantation of embryo; continues to be secreted if conception takes place
69
Mifepristone
Antiprogestin progesterone antagonist; partial agonist activity; administration in early pregnancy results in abortion of the fetus Inhibitor of Adrenocorticoid Biosynthesis or Function
70
Testosterone
Androgen bind to specific nuclear receptor; hormone-receptor complex binds to DNA and stimulates synthesis of specific RNAs and proteins anabolic agent - promotes bone growth and prevents reabsorption, development of internal genitalia, increases muscle mass; androgenic agent- development of male secondary sexual characteristics
71
Bicalutamide
Antiandrogen usually combined with GnRH analog to decrease LH and testosterone production
72
Flutamide
Antiandrogen blocks action of testosterone in target organs
73
Nilutamide
Antiandrogen usually combined with GnRH analog to decrease LH and testosterone production
74
Aspart
Diabetes - Insulin insulin tells the cells to absorb and store glucose
75
Glulisine
Diabetes - Insulin insulin tells the cells to absorb and store glucose
76
Lispro
Diabetes - Insulin insulin tells the cells to absorb and store glucose
77
Regular Insulin
Diabetes - Insulin insulin tells the cells to absorb and store glucose
78
NPH
Diabetes - Insulin insulin tells the cells to absorb and store glucose
79
Detemir
Diabetes - Insulin insulin tells the cells to absorb and store glucose
80
Glargine
Diabetes - Insulin insulin tells the cells to absorb and store glucose
81
Pramlintide
Diabetes - Amylinomimetic synthetic amylin analog; amylin is a hormone that is secreted along with insulin from beta cells following food intake; delays gastric emptying and decreases glucagon secretion; can be used as adjunct to mealtime insulin
82
Gliclazide
Diabetes - Sulfonylurea helps the body secrete more insulin; binds to receptors in the beta cells causing K channels to close; depolarizes membrane; voltage-dependent calcium channels open in response; activates calcium-dependent proteins that control the release of insulin; insulin release is increased
83
Glimepiride
Diabetes - Sulfonylurea helps the body secrete more insulin; binds to receptors in the beta cells causing K channels to close; depolarizes membrane; voltage-dependent calcium channels open in response; activates calcium-dependent proteins that control the release of insulin; insulin release is increased
84
Glipizide
Diabetes - Sulfonylurea helps the body secrete more insulin; binds to receptors in the beta cells causing K channels to close; depolarizes membrane; voltage-dependent calcium channels open in response; activates calcium-dependent proteins that control the release of insulin; insulin release is increased
85
Glyburide
Diabetes - Sulfonylurea helps the body secrete more insulin; binds to receptors in the beta cells causing K channels to close; depolarizes membrane; voltage-dependent calcium channels open in response; activates calcium-dependent proteins that control the release of insulin; insulin release is increased
86
Nateglinide
Diabetes - Meglitinide stimulate the pancreas to secrete more insulin; faster acting with shorter duration of action than sulfonylureas; developed to decrease postprandial hyperglycemia; bind to same receptor in beta cells as sulfonylureas; different site; cause similar release of insulin
87
Repaglinide
Diabetes - Meglitinide stimulate the pancreas to secrete more insulin; faster acting with shorter duration of action than sulfonylureas; developed to decrease postprandial hyperglycemia; bind to same receptor in beta cells as sulfonylureas; different site; cause similar release of insulin
88
Metformin
Diabetes - Biguanide lowers glucose production in the liver and improves body's sensitivity to insulin; decreases glucose production in the liver; increases hepatic sensitivity to insulin; reduces energy supply for production; decreases the amount of carbohydrate absorbed from intestines; increases insulin sensitivity in all cells and increases uptake in skeletal muscle
89
Pioglitazone
Diabetes - Thiazolidinediones improves whole-body insulin sensitivity; agonist at peroxisome proliferator-activated receptor-gamma; results in transcription of a number of insulin-sensitive genes; promotes or enhances the local effects of insulin
90
Rosiglitazone
Diabetes - Thiazolidinediones improves whole-body insulin sensitivity; agonist at peroxisome proliferator-activated receptor-gamma; results in transcription of a number of insulin-sensitive genes; promotes or enhances the local effects of insulin
91
Acarbose
Diabetes - Alpha-Glucosidase Inhibitor targets the alpha-glucosidase enzymes that break down complex carbohydrates; minimizes upper intestinal digestion and absorption of carbohydrates when taken at the start of a meal; decreases amount of glucose that is absorbed
92
Miglitol
Diabetes - Alpha-Glucosidase Inhibitor targets the alpha-glucosidase enzymes that break down complex carbohydrates; minimizes upper intestinal digestion and absorption of carbohydrates when taken at the start of a meal; decreases amount of glucose that is absorbed
93
Alogliptin
Diabetes - DPP-4 Inhibitor prolongs the activity of incretin hormones (GLP-1); inhibits DPP-IV; DPP-IV is responsible for inactivation of incretin hormones; prolonging the effect of the enzyme results in an increase in insulin secretion in response to meals and a decrease in glucagon levels; "helps the body continue to make insulin"
94
Linagliptin
Diabetes - DPP-4 Inhibitor prolongs the activity of incretin hormones (GLP-1); inhibits DPP-IV; DPP-IV is responsible for inactivation of incretin hormones; prolonging the effect of the enzyme results in an increase in insulin secretion in response to meals and a decrease in glucagon levels; "helps the body continue to make insulin"
95
Saxagliptin
Diabetes - DPP-4 Inhibitor prolongs the activity of incretin hormones (GLP-1); inhibits DPP-IV; DPP-IV is responsible for inactivation of incretin hormones; prolonging the effect of the enzyme results in an increase in insulin secretion in response to meals and a decrease in glucagon levels; "helps the body continue to make insulin"
96
Sitagliptin
Diabetes - DPP-4 Inhibitor prolongs the activity of incretin hormones (GLP-1); inhibits DPP-IV; DPP-IV is responsible for inactivation of incretin hormones; prolonging the effect of the enzyme results in an increase in insulin secretion in response to meals and a decrease in glucagon levels; "helps the body continue to make insulin"
97
Dulaglutide
Diabetes - GLP-1 Agonist GLP-1 is main incretin (responsible for postprandial insulin secretion); binds to GLP-1 receptors and acts as agonist; helps restore activity; results in potentiation of glucose-mediated insulin secretion (may actually increase beta-cell mass), suppression of postprandial glucagon release, and slowed gastric emptying and loss of appetite
98
Exenatide
Diabetes - GLP-1 Agonist GLP-1 is main incretin (responsible for postprandial insulin secretion); binds to GLP-1 receptors and acts as agonist; helps restore activity; results in potentiation of glucose-mediated insulin secretion (may actually increase beta-cell mass), suppression of postprandial glucagon release, and slowed gastric emptying and loss of appetite
99
Liraglutide
Diabetes - GLP-1 Agonist GLP-1 is main incretin (responsible for postprandial insulin secretion); binds to GLP-1 receptors and acts as agonist; helps restore activity; results in potentiation of glucose-mediated insulin secretion (may actually increase beta-cell mass), suppression of postprandial glucagon release, and slowed gastric emptying and loss of appetite
100
Lixisenatide
Diabetes - GLP-1 Agonist GLP-1 is main incretin (responsible for postprandial insulin secretion); binds to GLP-1 receptors and acts as agonist; helps restore activity; results in potentiation of glucose-mediated insulin secretion (may actually increase beta-cell mass), suppression of postprandial glucagon release, and slowed gastric emptying and loss of appetite
101
Semaglutide
Diabetes - GLP-1 Agonist GLP-1 is main incretin (responsible for postprandial insulin secretion); binds to GLP-1 receptors and acts as agonist; helps restore activity; results in potentiation of glucose-mediated insulin secretion (may actually increase beta-cell mass), suppression of postprandial glucagon release, and slowed gastric emptying and loss of appetite
102
Canagliflozin
Diabetes - Sodium-Glucose Transporter 2 Inhibitor prevents the kidneys from reabsorbing sugar into the blood; glucose is excreted in the urine; sodium-glucose cotransporter 2 is responsible for reabsorbing filtered glucose in the kidney - these drugs inhibit this activity; the result is an increase in urinary glucose excretion; may also reduce blood pressure (not a HTN treatment)
103
Dapagliflozin
Diabetes - Sodium-Glucose Transporter 2 Inhibitor prevents the kidneys from reabsorbing sugar into the blood; glucose is excreted in the urine; sodium-glucose cotransporter 2 is responsible for reabsorbing filtered glucose in the kidney - these drugs inhibit this activity; the result is an increase in urinary glucose excretion; may also reduce blood pressure (not a HTN treatment)
104
Empagliflozin
Diabetes - Sodium-Glucose Transporter 2 Inhibitor prevents the kidneys from reabsorbing sugar into the blood; glucose is excreted in the urine; sodium-glucose cotransporter 2 is responsible for reabsorbing filtered glucose in the kidney - these drugs inhibit this activity; the result is an increase in urinary glucose excretion; may also reduce blood pressure (not a HTN treatment)
105
Ertugliflozin
Diabetes - Sodium-Glucose Transporter 2 Inhibitor prevents the kidneys from reabsorbing sugar into the blood; glucose is excreted in the urine; sodium-glucose cotransporter 2 is responsible for reabsorbing filtered glucose in the kidney - these drugs inhibit this activity; the result is an increase in urinary glucose excretion; may also reduce blood pressure (not a HTN treatment)
106
Betamethasone
Corticosteroid - Glucocorticoid binds to specific intracellular cytoplasmic receptors anti-inflammatory action: decreases production of prostaglandins by inhibition of phospholipase A2- blocks release of AA; reduces COX-2 synthesis; interferes with mast cell degranulation; also lowers peripheral lymphocytes and macrophages (not seen with NSAIDs) promotes normal intermediary metabolism, increases resistance to stress, alters blood cell levels in plasma
107
Cortisone
Corticosteroid - Glucocorticoid binds to specific intracellular cytoplasmic receptors anti-inflammatory action: decreases production of prostaglandins by inhibition of phospholipase A2- blocks release of AA; reduces COX-2 synthesis; interferes with mast cell degranulation; also lowers peripheral lymphocytes and macrophages (not seen with NSAIDs) promotes normal intermediary metabolism, increases resistance to stress, alters blood cell levels in plasma
108
Dexamethasone
Corticosteroid - Glucocorticoid binds to specific intracellular cytoplasmic receptors anti-inflammatory action: decreases production of prostaglandins by inhibition of phospholipase A2- blocks release of AA; reduces COX-2 synthesis; interferes with mast cell degranulation; also lowers peripheral lymphocytes and macrophages (not seen with NSAIDs) promotes normal intermediary metabolism, increases resistance to stress, alters blood cell levels in plasma may be used in chemo-induced vomiting, usually in combination; mechanism may involve blockade of prostaglandins
109
Fludrocortisone
Corticosteroid - Mineralocorticoid binds to specific intracellular cytoplasmic receptors (mineralocorticoid receptors confined to secretory organs and brain) helps control the body's water volume and concentration of electrolytes; secretion is increased by angiotensin II and K, especially when Na levels are low
110
Hydrocortisone
Corticosteroid - Glucocorticoid binds to specific intracellular cytoplasmic receptors anti-inflammatory action: decreases production of prostaglandins by inhibition of phospholipase A2- blocks release of AA; reduces COX-2 synthesis; interferes with mast cell degranulation; also lowers peripheral lymphocytes and macrophages (not seen with NSAIDs) promotes normal intermediary metabolism, increases resistance to stress, alters blood cell levels in plasma
111
Methylprednisolone
Corticosteroid - Glucocorticoid binds to specific intracellular cytoplasmic receptors anti-inflammatory action: decreases production of prostaglandins by inhibition of phospholipase A2- blocks release of AA; reduces COX-2 synthesis; interferes with mast cell degranulation; also lowers peripheral lymphocytes and macrophages (not seen with NSAIDs) promotes normal intermediary metabolism, increases resistance to stress, alters blood cell levels in plasma may be used in chemo-induced vomiting, usually in combination; mechanism may involve blockade of prostaglandins
112
Prednisolone
Corticosteroid - Glucocorticoid binds to specific intracellular cytoplasmic receptors anti-inflammatory action: decreases production of prostaglandins by inhibition of phospholipase A2- blocks release of AA; reduces COX-2 synthesis; interferes with mast cell degranulation; also lowers peripheral lymphocytes and macrophages (not seen with NSAIDs) promotes normal intermediary metabolism, increases resistance to stress, alters blood cell levels in plasma
113
Triamcinolone
Corticosteroid - Glucocorticoid binds to specific intracellular cytoplasmic receptors anti-inflammatory action: decreases production of prostaglandins by inhibition of phospholipase A2- blocks release of AA; reduces COX-2 synthesis; interferes with mast cell degranulation; also lowers peripheral lymphocytes and macrophages (not seen with NSAIDs) promotes normal intermediary metabolism, increases resistance to stress, alters blood cell levels in plasma
114
Loteprednol
Corticosteroid - Glucocorticoid *ester-based steroid binds to specific intracellular cytoplasmic receptors anti-inflammatory action: decreases production of prostaglandins by inhibition of phospholipase A2- blocks release of AA; reduces COX-2 synthesis; interferes with mast cell degranulation; also lowers peripheral lymphocytes and macrophages (not seen with NSAIDs) promotes normal intermediary metabolism, increases resistance to stress, alters blood cell levels in plasma
115
Metyrapone
Inhibitor of Adrenocorticoid Biosynthesis or Function inhibits synthesis of cortisol
116
Aminoglutheamide
Inhibitor of Adrenocorticoid Biosynthesis or Function blocks conversion of cholesterol to pregnenolone; inhibits synthesis of ALL steroids
117
Ketoconazole
Inhibitor of Adrenocorticoid Biosynthesis or Function at high doses blocks enzyme responsible for steroid production
118
Spironolactone
Inhibitor of Adrenocorticoid Biosynthesis or Function blocks aldosterone receptors; also blocks androgen receptor
119
Eplerenone
Inhibitor of Adrenocorticoid Biosynthesis or Function blocks aldosterone receptors
120
Misoprostol
Prostaglandin Analog PGE1 analog; interacts with prostaglandin receptors on parietal cells; reduces gastric acid secretion; stimulates mucus and bicarbonate production inhibits secretion of HCl, stimulates secretion of mucus and bicarbonate, deficiency in production may be contributing factor in peptic ulcer development
121
Iloprost
Prostaglandin Analog analog of prostacyclin; activates prostacyclin receptors and increases production of cAMP
122
Latanoprost
Prostaglandin Analog PGF analog; binds to prostaglandin FP receptors and increases uveoscleral outflow; causes reduction of IOP
123
Travaprost
Prostaglandin Analog pro-drug; binds to prostaglandin FP receptors and increases uveoscleral outflow; causes reduction of IOP
124
Bimatoprost
Prostaglandin Analog mimics endogenous prostamides; binds to prostaglandin FP receptors and increases uveoscleral outflow; causes reduction of IOP
125
Aspirin
NSAID irreversibly inactivates cyclooxygenase; esterases rapidly break down into salicylate; salicylate has anti-inflammatory, antipyretic, and analgesic properties anti-inflammatory: inhibits cyclooxygenase activity, diminishing the formation of prostaglandins analgesic: PGE is thought to sensitize nerve endings to inflammatory chemical mediators, repressing sensation of pain antipyretic: PGE synthesis causes an increase in the set-point of the anterior hypothalamic thermoregulatory center, causing fever; NSAIDs reset the "thermostat" toward normal, with no effect on normal body temp
126
Indomethacin
NSAID - Acetic and Propionic Acids inhibits the synthesis of prostaglandins; inhibits cyclooxygenase enzymes, leading to decreased prostaglandin synthesis inhibits COX-1 and COX-2; reversible inhibition; does not effect leukotrienes
127
Ibuprofen
NSAID - Acetic and Propionic Acids inhibits the synthesis of prostaglandins; inhibits cyclooxygenase enzymes, leading to decreased prostaglandin synthesis inhibits COX-1 and COX-2; reversible inhibition; does not effect leukotrienes
128
Diclofenac
NSAID - Acetic and Propionic Acids inhibits the synthesis of prostaglandins; inhibits cyclooxygenase enzymes, leading to decreased prostaglandin synthesis inhibits COX-1 and COX-2; reversible inhibition; does not effect leukotrienes
129
Naproxen
NSAID - Acetic and Propionic Acids inhibits the synthesis of prostaglandins; inhibits cyclooxygenase enzymes, leading to decreased prostaglandin synthesis inhibits COX-1 and COX-2; reversible inhibition; does not effect leukotrienes
130
Ketorolac
NSAID - Acetic and Propionic Acids inhibits the synthesis of prostaglandins; inhibits cyclooxygenase enzymes, leading to decreased prostaglandin synthesis inhibits COX-1 and COX-2; reversible inhibition; does not effect leukotrienes
131
Meloxicam
NSAID - Oxicam inhibits the synthesis of prostaglandins; inhibits cyclooxygenase enzymes, leading to decreased prostaglandin synthesis preferential for COX-2, non selective at high doses
132
Peroxicam
NSAID - Oxicam inhibits the synthesis of prostaglandins; inhibits cyclooxygenase enzymes, leading to decreased prostaglandin synthesis
133
Celecoxib
NSAID - COX-2 Specific inhibits the synthesis of prostaglandins; inhibits cyclooxygenase enzymes, leading to decreased prostaglandin synthesis specific for COX-2
134
Acetaminophen
inhibits prostaglandin synthesis similar to COX-2 specific drugs (higher activity in the CNS); good antipyretic and analgesic; inactivated by chemicals found in inflammatory cells and platelets; poor anti-inflammatory and anti-platelet action; less effect on cyclooxygenase in peripheral tissues (weak anti-inflammatory activity)
135
Abatacept
Drugs for Arthritis (DMARDs) inhibits T-cell activation; biologic DMARD
136
Adalimumab
Drugs for Arthritis (DMARDs) TNF inhibitor (TNF is a pro-inflammatory cytokine); biologic DMARD
137
Anakinra
Drugs for Arthritis (DMARDs) IL-1 antagnoist (IL-1 is a pro-inflammatory cytokine); biologic DMARD
138
Certolizumab
Drugs for Arthritis (DMARDs) TNF inhibitor (TNF is a pro-inflammatory cytokine); biologic DMARD
139
Hydroxychloroquine
Drugs for Arthritis (DMARDs) increases pH within inflammatory cells; leads to interference with "antigen processing"; causes decreased stimulation of CD4 cells
140
Etanercept
Drugs for Arthritis (DMARDs) TNF inhibitor (TNF is a pro-inflammatory cytokine); biologic DMARD
141
Golimumab
Drugs for Arthritis (DMARDs) TNF inhibitor (TNF is a pro-inflammatory cytokine); biologic DMARD
142
Infliximab
Drugs for Arthritis (DMARDs) TNF inhibitor (TNF is a pro-inflammatory cytokine); biologic DMARD
143
Methotrexate
Drugs for Arthritis (DMARDs) immunosuppressant; inhibits dihydrofolate reductase; impairs DNA synthesis; aids in effectivness for autoimmune disease
144
Tocilizumab
Drugs for Arthritis (DMARDs) inhibits IL-6; biologic DMARD
145
Tofacitinib
Drugs for Arthritis (DMARDs) regulates immune cell function; biologic DMARD
146
Beclomethasone
Respiratory Drugs: Anti-Inflammatory Inhaled Corticosteroid decreases the inflammatory cascade: decreases production of prostaglandins by inhibition of phospholipase A2- blocks release of AA; reduces COX-2 synthesis; interferes with mast cell degranulation; also lowers peripheral lymphocytes and macrophages reduces the hyperresponsiveness of airway smooth muscle after several months of regular use
147
Budesonide
Respiratory Drugs: Anti-Inflammatory Inhaled Corticosteroid decreases the inflammatory cascade: decreases production of prostaglandins by inhibition of phospholipase A2- blocks release of AA; reduces COX-2 synthesis; interferes with mast cell degranulation; also lowers peripheral lymphocytes and macrophages reduces the hyperresponsiveness of airway smooth muscle after several months of regular use
148
Ciclesonide
Respiratory Drugs: Anti-Inflammatory Inhaled Corticosteroid decreases the inflammatory cascade: decreases production of prostaglandins by inhibition of phospholipase A2- blocks release of AA; reduces COX-2 synthesis; interferes with mast cell degranulation; also lowers peripheral lymphocytes and macrophages reduces the hyperresponsiveness of airway smooth muscle after several months of regular use
149
Flunisolide
Respiratory Drugs: Anti-Inflammatory Inhaled Corticosteroid decreases the inflammatory cascade: decreases production of prostaglandins by inhibition of phospholipase A2- blocks release of AA; reduces COX-2 synthesis; interferes with mast cell degranulation; also lowers peripheral lymphocytes and macrophages reduces the hyperresponsiveness of airway smooth muscle after several months of regular use
150
Fluticasone
Respiratory Drugs: Anti-Inflammatory Inhaled Corticosteroid decreases the inflammatory cascade: decreases production of prostaglandins by inhibition of phospholipase A2- blocks release of AA; reduces COX-2 synthesis; interferes with mast cell degranulation; also lowers peripheral lymphocytes and macrophages reduces the hyperresponsiveness of airway smooth muscle after several months of regular use
151
Mometasone
Respiratory Drugs: Anti-Inflammatory Inhaled Corticosteroid decreases the inflammatory cascade: decreases production of prostaglandins by inhibition of phospholipase A2- blocks release of AA; reduces COX-2 synthesis; interferes with mast cell degranulation; also lowers peripheral lymphocytes and macrophages reduces the hyperresponsiveness of airway smooth muscle after several months of regular use
152
Cromolyn
Respiratory Drugs: Anti-Inflammatory Mast Cell Stabilizer blocks release of inflammatory mediators
153
Montelukast
Respiratory Drugs: Anti-Inflammatory Anti-Leukotriene blocks effects of leukotrienes
154
Zafirlukast
Respiratory Drugs: Anti-Inflammatory Anti-Leukotriene blocks effects of leukotrienes
155
Zileuton
Respiratory Drugs: Anti-Inflammatory Anti-Leukotriene inhibitor of 5-lipoxygenase; prevents formation of leukotrienes
156
Albuterol
Respiratory Drugs: Bronchodilators | Short Acting Beta-2 Agonist
157
Levalbuterol
Respiratory Drugs: Bronchodilators | Short Acting Beta-2 Agonist
158
Pirbuterol
Respiratory Drugs: Bronchodilators | Short Acting Beta-2 Agonist
159
Formoterol
Respiratory Drugs: Bronchodilators | Long Acting Beta-2 Agonist
160
Indacaterol
Respiratory Drugs: Bronchodilators | Long Acting Beta-2 Agonist
161
Salmeterol
Respiratory Drugs: Bronchodilators | Long Acting Beta-2 Agonist
162
Ipratropium
Respiratory Drugs: Bronchodilators Cholinergic Agonist blocks contraction of airway smooth muscle mediated by vagus nerve; blocks acetylcholine receptors
163
Tiotropium
Respiratory Drugs: Bronchodilators Cholinergic Agonist blocks contraction of airway smooth muscle mediated by vagus nerve; blocks acetylcholine receptors
164
Theophylline
Respiratory Drugs: Bronchodilators nonspecific MOA; increases cAMP and antagonizes adenosine receptors
165
Omalziumab
Respiratory Drugs: Bronchodilators Immunoglobulin Antagonist recombinant DNA monoclonal antibody; selectively binds to IgE; decreases release of inflammatory mediators from mast cells and basophils
166
Codeine
Respiratory Drugs: Antitussives/Expectorants decreases sensitivity of cough centers in the CNS to peripheral stimuli; decreases mucosal secretion; required doses lower than required for analgesia
167
Dextromethorphan
Respiratory Drugs: Antitussives/Expectorants synthetic derivative of morphine; no analgesic effect at antitussive doses; equally effective as codeine
168
Benzonatate
Respiratory Drugs: Antitussives/Expectorants local anesthetic; anesthetizes respiratory passage and pleural stretch receptors; reduces cough reflex
169
Guaifenesin
Respiratory Drugs: Antitussives/Expectorants expectorant; facilitates the coughing up of mucus; exact MOA unknown; reduces adhesiveness and surface tension of respiratory tract secretions; facilitates expectoration; also reduces frequency of coughing
170
Cetirizine
Respiratory Drugs: Antihistamines H1 blockers
171
Diphenhydramine
Respiratory Drugs: Antihistamines H1 blockers
172
Fexofenadine
Respiratory Drugs: Antihistamines H1 blockers
173
Loratadine
Respiratory Drugs: Antihistamines H1 blockers
174
Amoxicillin
Drugs Used to Treat Peptic Ulcers: Antimicrobial Agents used in combination with PPIs to eradicate H. pylori
175
Bismuth Compounds
Drugs Used to Treat Peptic Ulcers: Antimicrobial Agents used in combination with PPIs to eradicate H. pylori
176
Clarithromycin
Drugs Used to Treat Peptic Ulcers: Antimicrobial Agents used in combination with PPIs to eradicate H. pylori
177
Metronidazole
Drugs Used to Treat Peptic Ulcers: Antimicrobial Agents used in combination with PPIs to eradicate H. pylori
178
Tetracycline
Drugs Used to Treat Peptic Ulcers: Antimicrobial Agents used in combination with PPIs to eradicate H. pylori
179
Cimetidine
Drugs Used to Treat Peptic Ulcers: H2 Receptor Blockers competitively block the binding of histamine; reduces secretion of gastric acid; have no effect on H1 receptors; no "regular" antihistamine effect
180
Famotidine
Drugs Used to Treat Peptic Ulcers: H2 Receptor Blockers competitively block the binding of histamine; reduces secretion of gastric acid; have no effect on H1 receptors; no "regular" antihistamine effect
181
Nizatidine
Drugs Used to Treat Peptic Ulcers: H2 Receptor Blockers competitively block the binding of histamine; reduces secretion of gastric acid; have no effect on H1 receptors; no "regular" antihistamine effect
182
Ranitidine
Drugs Used to Treat Peptic Ulcers: H2 Receptor Blockers competitively block the binding of histamine; reduces secretion of gastric acid; have no effect on H1 receptors; no "regular" antihistamine effect
183
Dexlansoprazole
Drugs Used to Treat Peptic Ulcers: Proton Pump Inhibitors (PPIs) binds to the proton pump and prevents secretion of hydrogen ions
184
Esemoeprazole
Drugs Used to Treat Peptic Ulcers: Proton Pump Inhibitors (PPIs) binds to the proton pump and prevents secretion of hydrogen ions
185
Lansoprazole
Drugs Used to Treat Peptic Ulcers: Proton Pump Inhibitors (PPIs) binds to the proton pump and prevents secretion of hydrogen ions
186
Omeprazole
Drugs Used to Treat Peptic Ulcers: Proton Pump Inhibitors (PPIs) binds to the proton pump and prevents secretion of hydrogen ions
187
Pantoprazole
Drugs Used to Treat Peptic Ulcers: Proton Pump Inhibitors (PPIs) binds to the proton pump and prevents secretion of hydrogen ions
188
Rebeprazole
Drugs Used to Treat Peptic Ulcers: Proton Pump Inhibitors (PPIs) binds to the proton pump and prevents secretion of hydrogen ions
189
Dicyclomine
Drugs Used to Treat Peptic Ulcers: Antimuscarinic Agents
190
Aluminium hydroxide
Drugs Used to Treat Peptic Ulcers: Antacids weak bases; react with gastric acid to form water and salt; also reduce pepsin activity; pepsin is inactive at pH >4
191
Calcium carbonate
Drugs Used to Treat Peptic Ulcers: Antacids weak bases; react with gastric acid to form water and salt; also reduce pepsin activity; pepsin is inactive at pH >4
192
Magnesium hydroxide
Drugs Used to Treat Peptic Ulcers: Antacids weak bases; react with gastric acid to form water and salt; also reduce pepsin activity; pepsin is inactive at pH >4 Constipation Drugs- saline and osmotic laxative nonabsorbale salts or electrolytes; holds water in the intestine by osmosis
193
Sodium bicarbonate
Drugs Used to Treat Peptic Ulcers: Antacids weak bases; react with gastric acid to form water and salt; also reduce pepsin activity; pepsin is inactive at pH >4
194
Bismuth subsalicylate
Drugs Used to Treat Peptic Ulcers: Mucosal Protective Agents has antimicrobial actions; inhibits pepsin activity; increases mucous secretion; coats and protects ulcer crater Drugs Used to Treat Diarrhea: Agents that Modify Fluid and Electrolyte Transport decreases fluid secretion
195
Sucralfate
Drugs Used to Treat Peptic Ulcers: Mucosal Protective Agents complex of aluminum hydroxide and sulfated sucrose; forms complex gel with epithelial cells and covers area of injury (like an artificial mucosal lining); impairs diffusion of HCl; also stimulates prostaglandin secretion
196
Prochlorperazine
Drugs Used to Treat Chemotherapy-Induced Nausea: Phenothiazines dopamine antagonist; block dopamine, histamine, and muscarinic receptors in the CTZ; effective against low emetogenic agents (better with higher dose but more side effects) anti-psychotic
197
Promethazine
Drugs Used to Treat Chemotherapy-Induced Nausea: Phenothiazines dopamine antagonist; block dopamine, histamine, and muscarinic receptors in the CTZ; effective against low emetogenic agents (better with higher dose but more side effects) antihistamine
198
Droperidol
Drugs Used to Treat Chemotherapy-Induced Nausea: Butyrophenones dopamine antagonist; can prolong QT interval; used in patients who do not respond to others
199
Haloperidol
Drugs Used to Treat Chemotherapy-Induced Nausea: Butyrophenones dopamine antagonist; can prolong QT interval; used in patients who do not respond to others
200
Metoclopramide
Drugs Used to Treat Chemotherapy-Induced Nausea: Substituted Benzamides dopamine antagonist
201
Alprazolam
Drugs Used to Treat Chemotherapy-Induced Nausea: Benzodiazepines low anti-emetic potency; effectiveness may come from sedative properties; great for anticipatory vomiting
202
Lorazepam
Drugs Used to Treat Chemotherapy-Induced Nausea: Benzodiazepines low anti-emetic potency; effectiveness may come from sedative properties; great for anticipatory vomiting
203
Dolasetron
Drugs Used to Treat Chemotherapy-Induced Nausea: 5-HT3 Receptor Blockers serotonin receptor blockers, 5-HT3 specific; effective against all agents and against signals arising from the GI tract; not effective for motion sickness or vertigo
204
Granisetron
Drugs Used to Treat Chemotherapy-Induced Nausea: 5-HT3 Receptor Blockers serotonin receptor blockers, 5-HT3 specific; effective against all agents and against signals arising from the GI tract; not effective for motion sickness or vertigo
205
Ondansetron
Drugs Used to Treat Chemotherapy-Induced Nausea: 5-HT3 Receptor Blockers serotonin receptor blockers, 5-HT3 specific; effective against all agents and against signals arising from the GI tract; not effective for motion sickness or vertigo
206
Palonosetron
Drugs Used to Treat Chemotherapy-Induced Nausea: 5-HT3 Receptor Blockers serotonin receptor blockers, 5-HT3 specific; effective against all agents and against signals arising from the GI tract; not effective for motion sickness or vertigo
207
Aprepitant
Drugs Used to Treat Chemotherapy-Induced Nausea: Substance P/Neurokinin-1 Receptor Blocker targets the neurokinin receptors in the CTZ; very effective for highly emetogenic agents
208
Diphenoxylate + atropine
Drugs Used to Treat Diarrhea: Antimotility Drugs have opioid-like actions on the gut; inhibit acetylcholine release and decrease peristalsis; lack analgesic effects at usual dose
209
Loperamide
Drugs Used to Treat Diarrhea: Antimotility Drugs have opioid-like actions on the gut; inhibit acetylcholine release and decrease peristalsis; lack analgesic effects at usual dose
210
Aluminum hydroxide
Drugs Used to Treat Diarrhea: Adsorbents act by adsorbing intestinal toxins and/or by coating the intestinal mucosa; much less effective than other classes
211
Methylcellulose
Drugs Used to Treat Diarrhea: Adsorbents act by adsorbing intestinal toxins and/or by coating the intestinal mucosa; much less effective than other classes Drugs Used to Treat Constipation: Bulk Laxatives form gels in the large intestine; cause water retention and intestinal distension; increases peristaltic activity
212
Bisacodyl
Drugs Used to Treat Constipation: Irritants and Stimulants stimulates the colon; acts directly on colon nerve cells
213
Castor oil
Drugs Used to Treat Constipation: Irritants and Stimulants irritates the stomach and initiates peristalsis
214
Senna
Drugs Used to Treat Constipation: Irritants and Stimulants stimulant laxative; causes evacuation of bowels and water/electrolyte secretion
215
Psyllium
Drugs Used to Treat Constipation: Bulk Laxatives form gels in the large intestine; cause water retention and intestinal distension; increases peristaltic activity
216
Magnesium sitrate
Drugs Used to Treat Constipation: Saline and Osmotic Laxatives nonabsorbable salts or electrolytes; holds water in the intestine by osmosis
217
Magnesium hydroxide
Drugs Used to Treat Constipation: Saline and Osmotic Laxatives nonabsorbable salts or electrolytes; holds water in the intestine by osmosis
218
Polyethylene glycol
Drugs Used to Treat Constipation: Saline and Osmotic Laxatives nonabsorbable salts or electrolytes; holds water in the intestine by osmosis
219
Lactulose
Drugs Used to Treat Constipation: Saline and Osmotic Laxatives nonabsorbable salts or electrolytes; holds water in the intestine by osmosis
220
Docusate
Drugs Used to Treat Constipation: Stool Softeners emollients and surfactants; takes longer to be effective; may be used more for prevention
221
Glycerin suppoistories
Drugs Used to Treat Constipation: Lubricant Laxatives
222
Mineral oil
Drugs Used to Treat Constipation: Lubricant Laxatives
223
Lubiprostone
Drugs Used to Treat Constipation: Chloride Channel Activators activates chloride channels; increases fluid secretion in the intestinal lumen