Drugs - The Basics: What kind of drug is this? Flashcards
Metformin
Oral hypoglycaemic agent (only clinically available bigunide)
Gliclazide
Sulphonylurea / oral hypoglycaemic agent
Glimepiride
Sulphonylurea / oral hypoglycaemic agent
Acarbose
α-glucosidase inhibitor / oral hypoglycaemic agent
Rosiglitazone
Glitazone / oral hypoglycaemic agent (withdrawn)
Pioglitazone
Glitazone / oral hypoglycaemic agent (rarely used)
Exenatide
Glucagon Like Peptide 1 Therapy / oral hypoglycaemic agent
Liraglutide
Glucagon Like Peptide 1 Therapy / oral hypoglycaemic agent
Lixisenatide
Glucagon Like Peptide 1 Therapy / oral hypoglycaemic agent
Sitagliptin
DPP-4 inhibitor / oral hypoglycaemic agent
Vidagliptin
DPP-4 inhibitor / oral hypoglycaemic agent
Saxagliptin
DPP-4 inhibitor / oral hypoglycaemic agent
Linagliptin
DPP-4 inhibitor / oral hypoglycaemic agent
Dapagliflozin
SGLT2 Inhibitor / oral hypoglycaemic agent
Canagliflozin
SGLT2 Inhibitor / oral hypoglycaemic agent
Empagliflozin
SGLT2 Inhibitor / oral hypoglycaemic agent
Insulin
Naturally Occurring Protein - Synthetic analogues injected as hypoglycaemic agents
FiAsp
Ultrafast acting insulin
Humalog
Rapid acting insulin
Novorapid/Aspart
Rapid acting insulin
Apidra
Rapid acting insulin
Isophane or NPH Insulins
Intermediate acting insulins
Glargine
Long/Very Long acting insulin
Detemir
Long/Very Long acting insulin
Degludec
Long/Very Long acting insulin
Novomix 30
Fixed combination insulin therapy - 30% rapid, 70% intermediate acting
Humulin M3
Fixed combination insulin therapy - 30% rapid, 70% intermediate acting
Progesterone
Sex steroid hormone
Oestrogens
Group of sex steroid hormones
Testosterone
Androgen / Sex steroid hormone
Clomiphene
Synthetic anti-oestrogen
RU486/Mifepristone
Steroidal Anti-progestogen
Finasteride
5α-reductase inhibitor / Synthetic androstane steroid
Prevents testosterone conversion to DHT
Selective oestrogen receptor modulators (SERMs)
Mixed agonist/antagonist of oestrogen
Raloxifene
SERM - protects against osteoporosis
Tamoxifen
SERM - ER positive breast cancer
Selective Progesterone receptor modulators (SPRMs)
Mixed agonist/antagonist of progesterone
Ulipristal acetate
SPRMs (emergency contraception)
Equilenin
Oestrogen derivative used in HRT
Ethinyl estradiol
Synthetic Derivative Oestrogen Analogues
Mestranol
Synthetic Derivative Oestrogen Analogues
Quinestrol
Synthetic Derivative Oestrogen Analogues
17α-Hydroxyprogesterone caproate
Synthetic progesterone derivative (delays onset of labour to prevent preterm birth)
Norgestrel
Synthetic testosterone derivative
Levonorgestrel
Synthetic testosterone derivative (morning after pill, POP)
Desogestrel
Synthetic testosterone derivative (POP)
COCP
Oestrogen and progestin formulation
POP
Progestin combination pill
Norethisterone
Synthetic progesterone derivative (POP)
Premarin
Conjugated oestrogen tablet - HRT
Statin
Lipid-lowering drug
Cholesterol lipase inhibitors
Lipid-lowering drug
Fibrates
Lipid-lowering drug - PPAR-α agonists
Omega-3 fatty acids
Lipid-lowering drug
Resins
Lipid-lowering drug
Simvastatin
Short-acting Statin
Atorvastatin
Statin
Rosuvastatin
Statin
Ezetimibe
Cholesterol lipase inhibitor
Nicotinic acid/niacin
Lipid lowering drug
Omacar
Omega-3 fatty acid
Fenofibrate
Fibrate/Fibric Acid Derivative
Statin plus
Combination therapy for High Cholesterol - fibrate, nicotinic aicd, ezetimibe, omega-3 FAs.
Aciclovir
Anti-Herpes virus drug - guanasine nucleoside analogues (HSV1/2, VZV)
Valaciclovir
Anti-Herpes virus drug - guanasine nucleoside analogues (HSV1/2, VZV)
Penciclovir
Anti-Herpes virus drug - guanasine nucleoside analogues (HSV1/2, VZV)
Famciclovir
Anti-Herpes virus drug - guanasine nucleoside analogues (HSV1/2, VZV)
Ganciclovir
Anti-Herpes virus drug - guanasine nucleoside analogues (Better for CMV)
Valganciclovir
Anti-Herpes virus drug - guanasine nucleoside analogues (Better for CMV)
Cidofovir
Anti-Herpes virus drug - cytidine nucleotide analogues (for all HSVs)
Foscarnet
Anti-Herpes virus drug - pyrophosphate analogue
Lamivudine
Anti Hepatitis B Drug - Cytidine nucleoside analogue
Adefovir
Anti Hepatitis B Drug - Adenosine nucleotide analogue
Emtricitabine
Anti Hepatitis B Drug - 5’ fluorinated nucleoside analogue derivative
Entecavir
Anti Hepatitis B Drug - Guanasine nucleoside analogue
Telbivudine
Anti Hepatitis B Drug - Thymidine Analogue
Ribavirin
Anti Hepatitis C Drug - Guanosine Analogue
IFN-α
Interferon - HBV and HCV (endogenously from mast cells)
IFN-β
Interferon - HBV and HCV (endogenously from mast cells)
IFN-γ
Interferon - HBV and HCV (endogenously from T cells & NK cells)
Amantadine
Anti-influenza drug - symmetric tricyclic amine
Rimantidine
Anti-influenza drug - symmetric tricyclic amine
Oseltamivir
Anti-influenza drug - Neuraminidase Inhibitor
Zanamivir
Anti-influenza drug - Neuraminidase Inhibitor
Maribavir
New Antiviral for CMV
Pleconaril
New Antiviral for Entero-/Rhino-viruses
NRTIs
Nucleoside reverse transcriptase inhibitors (HIV1 and HIV2)
Zidovudine
NRTI
Didanosine
NRTI
Stavudine
NRTI
Lamivudine
NRTI
Abacavir
NRTI
Emtricitabine
NRTI
Tenofovir
NRTI (nucleotide)
NNRTIs
Non-nucleoside reverse transcriptase inhibitors (HIV1, not HIV2)
Nevirapine
NNRTI
Delavirdine
NNRTI
Efavirenz
NNRTI
Etravirine
NNRTI
Rilpivirine
NNRTI
PIs
Protease Inhibitors (HIV1 and HIV2)
FIs
Fusion Inhibitors (HIV1)
Enfuvirtide
FI (HIV1)
Maraviroc
Enry Inhibitor (New Anti-retroviral drug)
Raltegravir
Integrase Inhibitor (New Anti-retroviral drug)
Ciprofloxacin
Quinolone
Quinolones
Antimicrobials targetting DNA synthesis (via DNA gyrase inhibition)
Trimethaprim
Folic Acid Antagonist
Sulphonamides
Folic Acid Antagonist
Folic Acid Antagonists
Antimicrobials targetting DNA synthesis
Gentamicin
Aminoglycoside
Aminoglycosides
Antimicrobials targetting protein synthesis
Erythromicin
Macrolide
Macrolides
Antimicrobials targetting protein synthesis
Tetracyclines
Antimicrobials targetting protein synthesis
Penicillins
Beta-lactams
Cephalosporins
Beta-lactams
Carbapenems
Beta-lactams
Beta-lactams
Antimicrobials targetting cell wall synthesis
Vancomycin
Glycopeptide Antimicrobial
Glycopeptide
Antimicrobials targetting cell wall synthesis
Corticosteroids
Immunosuppressants
Azathioprine
Immunosuppressant (often as a “steroid-sparing” drug) - Inflammatory Bowel Disease, SLE, Vasculitis
Ciclosporin
Immunosuppressant (Calcineurin Inhibitor) - transplants, atopic dermatitis, psoriasis
Tacrolimus
Immunosuppressant (Calcineurin Inhibitor) - transplants, atopic dermatitis, psoriasis
Mycophenolate mofetil
Immunosuppressant (“Sniper fire”) - transplants, lupus nephritis
Prednisone
Corticosteroid for severe RA
Methotrexate
DMARD with anti-folate action - RA, malignancy, severe psoriasis, Crohn’s
DMARDs
Disease Modifying Anti-Rheumatic Drugs
Sulfasalazine
DMARD
Biopharmaceuticals including Anti-TNFα
DMARD
Adalimumab
Biopharmaceutical DMARD
Infliximab
Biopharmaceutical DMARD
Rituximab
Biopharmaceutical DMARD - Depletes B Cells
Cyclophosphamide
Very toxic but effective DMARD (alkylating agent) - also a chemo agent
Salbutamol
Short acting β2 agonist (inhaled)
Terbutaline
Short acting β2 agonist (inhaled)
Formoterol
Fast onset, Long duration β2 agonist (inhaled)