Drugs that cause enzyme inhibition

Question 1

Cimetidine

Answer 1

CYP3A

Question 2

Ciprofloxacin

Answer 2

CYP1A2/CYP3A

Question 3

Clopidogrel

Answer 3

not complete

Question 4

Macrolides (Erythromycin/Clarithromycin/Telithromycin)

Answer 4

CYP3A4/CYP3A5/CYP3A7

Question 5

Fluvoxamine

Answer 5

CYP1A2

Question 6

Protease Inhibitors (Nelfinavir/Ritonavir/Indinavir/Saquinavir)

Answer 6

CYP3A

Question 7

Grapefruit Juice

Answer 7

CYP3A

Question 8

Bupropion

Answer 8

CYP2D6

Question 9

Fluoxetine/Paroxetine

Answer 9

CYP2D6

Question 10

Azole Antifungals (Metronidazole/Voriconazole/Itraconazole/Ketoconazole)

Answer 10

CYP3A

Question 11

Fluconazole

Answer 11

CYP2C9/CYP3A

Question 12

Sodium Valproate

Answer 12

not complete

Question 13

Isoniazid

Answer 13

not complete

Question 14

Alcohol

Answer 14

not complete

Question 15

Chloramphenicol

Answer 15

not complete

Question 16

Sulfonamides

Answer 16

not complete

Question 17

Omeprazole

Answer 17

not complete

Question 18

What is the enzyme inhibitors pneumonic?

Full and current list of enzyme inhibitors available at: https://drug-interactions.medicine.iu.edu/Main-Table.aspx

Answer 18

S - sodium valproate
I - isoniazid
C - cemetidine
K - ketoconazole
F - fluconazole
A - alcohol
C - chloramphenicol
E - erythromycin
S - sulfonamides
.
C - ciprofloxacin
O - omeprazole
M - metronidazole

& HIV antivirals/protease inhibitors (e.g. ritonavir)

Question 19

Gemfibrozil

Answer 19

CYP2C8

Question 20

Cinacalcet

Answer 20

CYP2D6

Question 21

Quinidine

Answer 21

CYP2D6

Question 22

indinavir/nelfinavir/ritonavir

Answer 22

CYP3A4/CYP3A5/CYP3A7