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Drug Facts Misc. > Drugs that cause enzyme inhibition > Flashcards

Drugs that cause enzyme inhibition Flashcards

1
Q

Cimetidine

A

CYP3A

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2
Q

Ciprofloxacin

A

CYP1A2/CYP3A

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3
Q

Clopidogrel

A

not complete

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4
Q

Macrolides (Erythromycin/Clarithromycin/Telithromycin)

A

CYP3A4/CYP3A5/CYP3A7

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5
Q

Fluvoxamine

A

CYP1A2

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6
Q

Protease Inhibitors (Nelfinavir/Ritonavir/Indinavir/Saquinavir)

A

CYP3A

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7
Q

Grapefruit Juice

A

CYP3A

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8
Q

Bupropion

A

CYP2D6

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9
Q

Fluoxetine/Paroxetine

A

CYP2D6

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10
Q

Azole Antifungals (Metronidazole/Voriconazole/Itraconazole/Ketoconazole)

A

CYP3A

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11
Q

Fluconazole

A

CYP2C9/CYP3A

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12
Q

Sodium Valproate

A

not complete

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13
Q

Isoniazid

A

not complete

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14
Q

Alcohol

A

not complete

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15
Q

Chloramphenicol

A

not complete

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16
Q

Sulfonamides

A

not complete

17
Q

Omeprazole

A

not complete

18
Q

What is the enzyme inhibitors pneumonic?

Full and current list of enzyme inhibitors available at: https://drug-interactions.medicine.iu.edu/Main-Table.aspx

A 
S - sodium valproate
I - isoniazid
C - cemetidine
K - ketoconazole
F - fluconazole
A - alcohol
C - chloramphenicol
E - erythromycin
S - sulfonamides
.
C - ciprofloxacin
O - omeprazole
M - metronidazole

& HIV antivirals/protease inhibitors (e.g. ritonavir)

19
Q

Gemfibrozil

A

CYP2C8

20
Q

Cinacalcet

A

CYP2D6

21
Q

Quinidine

A

CYP2D6

22
Q

indinavir/nelfinavir/ritonavir

A

CYP3A4/CYP3A5/CYP3A7

Drug Facts Misc. (20 decks)

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