drugs that affect U+E's

Question 1

What are the main drug groups that cause Hyponatraemia?

Answer 1

• diuretics (especially thiazides)
• selective serotonin reuptake inhibitors (SSRIs),
• antipsychotics such as haloperidol,
• nonsteroidal anti-inflammatories
• carbamazepine.

Question 2

What is the main mode of action by which drugs cause Hyponatraemia?

Answer 2

Most drugs that cause hyponatraemia do it by increasing the production of, or potentiating the action of antidiuretic hormone (ADH)