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Dynamics 3 - Exam 4 > Drugs - Tertiary TCAs > Flashcards

Drugs - Tertiary TCAs Flashcards

1
Q

Which are the tertiary TCA antidepressants?

A
  • Amitriptyline (Elavil)
  • Doxepin (Sinequan)
  • Trimipramine (Surmontil)
  • Imipramine (Tofranil)
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2
Q

What are the characteristics of Amitriptyline?

A
  • Most potent anti-cholinergic (tachycardia)
  • most cardio toxic antidepressant (quinidine-like effect)
  • most balanced NE vs 5HT reuptake inhibition among the TCAs
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3
Q

What are the characteristics of doxepin?

A
  • Most potent H1 blocker (highly sedating)

- 10-50x more potent H1 blocker than Benadryl

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4
Q

What are the characteristics of trimipramine?

A

Blocks H2 as potently as Cimetidine (antacid effect)

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5
Q

What are the characteristics of imipramine?

A
  • Prototype TCA

- greatest incidence of orthostatic hypotension

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Dynamics 3 - Exam 4 (12 decks)

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