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Dynamics 3 - Exam 4 > Drugs - MAOIs > Flashcards

Drugs - MAOIs Flashcards

1
Q

What are the characteristics common to all MAOIs?

A
  • Irreversible Flavin inhibitor
  • last resort antidepressant
  • MOA: down regulate (desensitize) 5HT1A and terminal alpha-2
  • dietary restrictions: tyramine containing foods
  • contraindications: OTC decongestants, triptan anti-migraine agents, meperidine, tramadol, SSRIs, L-DOPA, bupropion
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2
Q

Which are the MAOIs?

A
  • Hydrazines
  • Cyclopropylamines
  • Propargylamines
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3
Q

What are the characteristics of the hydrazines?

A
  • Hepatotoxic
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4
Q

What are the characteristics of cyclopropylamines?

A
  • May inhibit MAO reversibly

- Tranylcypromine (Parnate) - amphetamine derivative so stimulant like effects may lead to insomnia and agitation

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5
Q

What are the characteristics of propargylamines?

A
  • Selegiline patch - only useful at doses that inhibit both MAO-A and MAO-B
  • only antidepressant administered as a transdermal patch
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Dynamics 3 - Exam 4 (12 decks)

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