Drugs/Pharm

Question 1

Thrombolysis AMI

Answer 1

1. Aspirin
2. Clexane
   Give enoxaparin between 15 minutes before and 30 minutes after the start of treatment. Treat for up to 8 days.

<75 years, IV 30 mg bolus plus SC 1 mg/kg, then SC 1 mg/kg every 12 hours (maximum 100 mg for the first 2 SC doses).

> 75 years, CrCl <30 mL/minute, SC 1 mg/kg once daily (maximum 75 mg for the first dose).

3. Thrombolytic agent
   Tenectaplase
   0.5 mg/kg up to 50mg
   Consider half dose for > 75 years

Question 2

Thrombolysis PE

Answer 2

Alteplase
IV, bolus of 10 mg, then 90 mg infused over 2 hours
(if <65 kg total dose = 1.5 mg/kg).

Cardiac arrest 50mg IV, then rpt 15 mins later

Tenectaplase
0.5 mg/kg up to 50mg
Consider 0.25mg/kg for >75 years
Same dose for cardiac arrest

Question 3

Local Anaesthetics

Answer 3

Question 4

Decreasing pain from LA injection

Answer 4

1. Distraction
2. Topical use prior
3. LA
   a. Smallest volume possible
   b. Warming to 37
   c. Buffering 1:10 4.2% NaHCO3
4. Technique
   a. Finest, longest needle
   b. Inject through open wound
   c. Slow speed
5. Regional block for larger area

Question 5

Amiodarone side effects

Answer 5

Question 6

Warfarin - INR

Answer 6

Question 7

IBW vs LBW vs TBW for anaesthesia

Answer 7

Question 8

Induction agents

Answer 8

Question 9

Inotropes

Answer 9

Question 10

Antiarrhythmics - Vaughan Williams Classification

Answer 10