DRUGS ON DYSLIPIDMIA AND CASE ON LIPIDS

Question 1

Classified as a high intensity statin:

a. Simvastatin 10 mg
b. Atorvastatin 10 mg
c. Lovastatin 5 mg
d. Rosuvastatin

Answer 1

d. Rosuvastatin 20 mg

Question 2

Which of the following is a modifiable risk factor:

a. Smoking
b. Age
c. Sex
d. Ethnicity

Answer 2

a. Smoking

Question 3

It is the most atherogenic lipoprotein:

a. HDL-c
b. LDL-c
c. VLDL-c
d. Triglycerides

Answer 3

b. LDL-c

Question 4

It is the target LDL-c in patients with hypertension and other co-morbidities:

a. 200 mg/dL
b. 150mg/dL
c. >200 mg/dL
d. <100 mg/dL

Answer 4

d. <100 mg/dL

Question 5

It is the target HDL-c to improve cardiovascular outcome:

a. 40 mg/dL
b. <40 mg/dL
c. 50 mg/dL
d. >50 mg/dL

Answer 5

d. >50 mg/dL

Question 6

It is one of the most important side effect of statins that needs to emphasize in the patient:

a. Dermatitis
b. Arthritis
c. Rhabdomyolysis
d. Gastritis

Answer 6

c. Rhabdomyolysis

Question 7

A statin that can be taken anytime of the day

a. Simvastatin
b. Rosuvastatin
c. Pravastatin
d. Lovastatin

Answer 7

b. Rosuvastatin

Question 8

Which of the ff is an acute fatal complication of severe hypertriglyceridemia?

a. Hepatits
b. Myositis
c. Rhabdomyolysis
d. Pancreatitis

Answer 8

d. Pancreatitis

Question 9

Which of the ff has the highest source of triglycerides in the diet?

a. Rice
b. Legumes
c. Meat
d Alcohol

Answer 9

a. Rice

Question 10

It has the greater reduction in the level of triglycerides

a. Niacin
b. Cholestyramine
c. Statin
d. Fibrates

Answer 10

d. Fibrates

Question 11

Which of the ff is true regarding the mechanism of action of HMG-CoA reductase inhibitor?

a. Inhibits the last step of in sterol biosynthesis
b. Induce an increase in high affinity LDL receptors
c. Decrease the fractional catabolic rate of LDL
d. Decreases the hepatic extraction of LDL precursors

Answer 11

b. Induce an increase in high affinity LDL receptors

Question 12

All but one statin should be given at night because cholesterol synthesis occurs predominantly at night

a. Fluvastatin
b. Pravastatin
c. Rosuvastatin
d. Simvastatin

Answer 12

c. Rosuvastatin

Question 13

Absorption of this statin is affected by the presence of food

a. Rosuvastatin
b. Pravastatin
c. Atorvastatin
d. Lovastatin

Answer 13

b. Pravastatin

Question 14

The catabolism of this drug proceeds chiefly through CYP2C9

a. Rosuvastatin
b. Lovastatin
c. Simvastatin
d. Atorvastatin

Answer 14

a. Rosuvastatin

Question 15

It functions primarily as ligands for the nuclear transcription receptor PPAR-alpha

a. Niacin
b. Statin
c. Fibrates
d. Coleveselam

Answer 15

c. Fibrates

Question 16

It inhibits VLDL secretion thus decreasing the production of of LDL and increased clearance of VLDL via the LPL pathway

a. Niacin
b. Fibrates
c. Coleveselam
d. Ezetimibe

Answer 16

a. Niacin

Question 17

Which of the ff is true regarding HDL?

a. Stimulates oxidation of atherogenic lipoproteins
b. Promotes deposition of cholesterol in artery wall
c. Causes an impaired cholesterol retrieval
d. Helps reduce the levels of atherogenic lipoproteins

Answer 17

d. Helps reduce the levels of atherogenic lipoproteins

Question 18

It is formed in the intestines and carry triglycerides of dietary origin

a. Chylomicrons
b. LDL
c. VLDL
d. IDL

Answer 18

a. Chylomicrons

Question 19

It is secreted by the liver and exports triglycerides to peripheral tissues

a. LDL
b. VLDL
c. HDL
d. IDL

Answer 19

b. VLDL

Question 20

It is an important component of metabolic syndrome aside from insulin resistance, HPN, and abdominal obesity:

a. Hypertriglyceridemia
b. Uremia
c. Polycythemia
d. Anemia

Answer 20

a. Hypertriglyceridemia