Drugs Of Cytoskeleton Flashcards
0
Q
Phalloidin
A
- from the death cap mushroom
- toxin stabilizes F actin by locking adjacent subunits together killing the cell
1
Q
Actin stabilizing drugs
A
- Phalloidin
- Jasplakinolide
2
Q
Jasplakinolide
A
- macrocyclic peptide isolated from the marine sponge
- F actin polymerizing and stabilizing drug
3
Q
Actin depolymerising drugs
A
- Latrunculin
- Cytochalasin D
4
Q
Latrunculin
A
- toxin from Red Sea sponge that binds to acid monomers and prevents them from being added onto filaments
5
Q
Cytochalasin D
A
- fungal toxin which bonds to the barbed end of F actin and prevents polymerization
6
Q
Action of drugs on Microtubules
A
- colchicine
- vinblastine/vincristine
- nocodazole
- oryzalin
- taxol
7
Q
Colchicine
A
Inhibits polymerization (dimer binding)
8
Q
Vinblastine/ vincristine
A
Inhibits polymerization (dimer binding)
- suppresses MT dynamics
- MT depolymerization
- used to treat Hodgkin’s disease, bladder cancer, advances testicular cancer, breast cancer, Kaposi’s sarcoma
9
Q
Nocodazole
A
Inhibits polymerization (dimer binding)
10
Q
Oryzalin
A
Inhibits polymerization (dimer binding)
11
Q
Taxol
A
Favors polymerization (polymer binding)
- stabilizes MTs
- inhibits mitosis
- used to treat ovarian/breast carcinomas and lung cancer
12
Q
MT binding drugs often used as anti-cancer agents
A
- most adult calls are quiescent
- cancer cells are actively dividing
- MTs in mitotic spindle are essential for cell proliferation
- many anti- cancer drug target MTs to stop them from dividing
