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Psych > Drugs of Abuse DSA > Flashcards

Drugs of Abuse DSA Flashcards

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1
Q

opioid R antagonist

A
  • Naloxone

- Naltrexone

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2
Q

synthetic opioid

A

-methadone

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3
Q

partial u-opioid R agonist

A

Buprenorphine

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4
Q

nicotinic R partial agonist

A

-varenicline

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5
Q

benzodiazepines

A
  • oxazepam

- lorazepam

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6
Q

NMDA R antagonist

A

-Acamprosate

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7
Q

dopamine hypothesis of addiction

A

(DA reward pathway)

-drugs act the mesolimbic DA system- release DA

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8
Q

nonaddictive drugs of abuse

A
  • LSD, mescaline, psilocybin

- PCP, ketamine

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9
Q

drugs that act Gio-coupled R’s

A

cause disinhibition of DA neurons

  • opioids
  • cannabinoids
  • GHB
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10
Q

opioids- moa

A

-inhibition of GABAergic inhibitory interneurons- disinhibition of dopamine neurons

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11
Q

opioids- tx

A
  • naloxone- opioid antagonist (within minutes)

- methadone, buprenorphine- long-acting opioids used for substitution therapy

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12
Q

cannabinoids- moa

A
  • THC- disinhibition of DA neurons by presynaptic inhibition of GABA neurons in VTA
  • CBD, CBN
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13
Q

GHB (gamma-hydroxybutyric acid)- moa

A
  • produced during the metabolism of GABA
  • act GABAb R
  • liquid ecstasy or date rape drug
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14
Q

drugs that mediate their effects via ionotropic Rs

A
  • nicotine
  • benzodiazepines and barbiturates
  • alcohol
  • inhalants
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15
Q

Nicotine- moa

A
  • agonist of nACHR

- neuronal nACHRs are expressed on DA neurons in VTA- activation fulfills the DA requirement of addictive drugs

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16
Q

nicotine- tx

A
  • nicotine
  • bupropion- antidepressant
  • varenicline- partial neuronal nACHR agonist
17
Q

drugs that bind to transporters of biogenic amines

A

(DAT, NET, VMAT, SERT)

  • cocaine
  • amphetamines
  • ecstasy
18
Q

cocaine- moa

A
  • PNS- inhibits voltage-gated Na channels
  • blocks DAT- inc DA conc in NA
  • blocks NET- act SNS
19
Q

amphetamines- moa

A
  • causes release of endogenous biogenic amines by reversing the action of biogenic amine transporters at the plasma memb
  • taken up into the cell by DAT
  • block intracellular VMAT- deplete synaptic vesicles of their nt content- causes DA, serotonin, NE to inc in cytoplasm- released into synapse

Psych (16 decks)

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