Drugs of abuse

Question 1

MOA of Cocaine

Answer 1

Inhibits NET

increasing DA

Question 2

MOA of Amphetamine, methamphetamine

Answer 2

Causes intracellular release of dopamine, NE and serotonin within the terminal

MAO inhibition

Facilitates “reverse transport” of neurotransmitter back into the cleft

Question 3

MOA of Bath salt

Answer 3

Causes intracellular release of dopamine, NE and serotonin within the terminal

MAO inhibition

Facilitates “reverse transport” of neurotransmitter back into the cleft

Question 4

MOA of Ecstasy (MDMA)

Answer 4

Causes intracellular release of serotonin within the terminal

MAO inhibition

Facilitates “reverse transport” of serotonin back into the cleft

Question 5

MOA of PCP/Ketamine

Answer 5

NMDA receptor antagonist

Question 6

MOA of Marijuana

Answer 6

Tetrahydrocanabinol (THC)

Question 7

MOA of Dronabinol

Answer 7

Synthetic, partial agonist for CB1 receptor

Question 8

MOA of Synthetic cannabinoid
Spice
K2

Answer 8

Full cannabinoid receptor agonist

CBD does not contain THC, so has not psychoactive effects

Question 9

ADR of Cocaine (terms of NE, DA, serotonin)

Answer 9

Increase NE: heart contraction and heart rate increase, hypertension, mydriasis, excitation, hyperactivity

Increase DA: psychotic episode, paranoia, hallucinations, prolactin decreases

Increase serotonin: aggressive, dyskinesia, decrease appetite