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Pharm block 4 > Anti epileptics > Flashcards

Anti epileptics Flashcards

1
Q

MOA of Phenytoin

A

Blocks the presynaptic fast Na+ channel (Glutamate neuron)

Induces p450

Zero order elimination

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2
Q

MOA of Carbamazepine

A

Blocks the presynaptic fast Na+ channel (Glutamate neuron)

Induces p450

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3
Q

MOA of Valproic acid

A
  1. Blocks the presynaptic fast Na+ channel (Glutamate neuron)
  2. T-type Ca++ channel blocker in the thalamus
  3. Blocks GABA transaminase, increasing GABA

Inhibits p450

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4
Q

MOA of Ethosuximide

A

T-type Ca++ channel blocker in the thalamus

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5
Q

MOA of Lamotrigine, Topiramate

A

AMPA antagonist

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6
Q

MOA of Gabapentine

A

N-calcium channel blocker, increases GABA release

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7
Q

Uses of Phenytoin

A

maintenance of status epilepticus treatment

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8
Q

Uses of Carbamazepine

A

Trigeminal neuralgia

Mania

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9
Q

Uses of Valproic acid

A

DOC for absent seizures (ethosuximide too)
Mania
Migraines
Tonic-clonic seizures

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10
Q

Uses of Ethosuximide

A

DOC for absent seizures (valproate too)

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11
Q

Uses of Lamotrigine, Topiramate

A

adjunct drugs for seizures

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12
Q

Uses of Gabapentine

A 
Seizures 
Postherpetic neuralgia (shingles)
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13
Q

ADR of Phenytoin

A

Diplopia; ataxia; dizziness; nystagmus; tremor; sedation

Gingival hyperplasia
Hirsuitism 
Megaloblastic anemia
Osteomalacia 
Aplastic anemia
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14
Q

ADR of Carbamazepine

A 
Diplopia
Ataxia 
Agranulocytosis; aplastic anemia 
Hyponatremia (SIADH → diluted)
Megaloblastic anemia
Osteomalacia 
Exfoliative dermatitis
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15
Q

ADR of Valproic acid

A

Liver dysfunction
Thrombocytopenia
Pancreatitis
Alopecia

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16
Q

ADR of Lamotrigine, Topiramate

A

Steven Johnson syndrome

17
Q

Contraindication of Phenytoin

A

Absence seizures

Teratogenicity: cleft lip and palate, fetal hydantoin syndrome (MR)

18
Q

Contraindication of Carbamazepine

A

Absence seizures

Teratogenicity: cleft lip and palate, spina bifida

19
Q

Contraindication of Valproic acid

A

Teratogenicity: spina bifida (NTDs)

Pharm block 4 (16 decks)

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