Drugs of Abuse

Question 1

What do drugs of abuse do?

Answer 1

enhance release of dopamine from VTA neurones (GABA inhibits neuronal activity)

Question 2

How do opiates work

Answer 2

agonists at G protein-coupled opioid receptors that lower NT release in brain and periphery

Question 3

What is the mechanism of action of Cocaine?

Answer 3

increases catecholamine neurotransmitter function by preventing reuptake

Question 4

How do Amphetamines work?

Answer 4

release monoamines from neuronal storage vesicles and block re-uptake causing increased synaptic DA, NA and 5HT

Question 5

What is the mechanism of action of Cannabis

Answer 5

Inhibits wide range of NT release via specific Gi protein-coupled cannabinoid receptors.

Question 6

What is Methadone

Answer 6

Long-acting synthetic opioid agonist, blocks effects of opiate use.

Question 7

What does Naltrexone do and how does it work?

Answer 7

reduces alcohol craving by interfering with positive reinforcement. blocks endogenous opioid dis-inhibition of GABA neurones in VTA therefore reducing firing of dopamine releasing neurones