ADME Flashcards
1
Q
What’s the difference between metoclopramide and domperidone
A
Both anti-emetics
Metoclopramide penetrates BBB and can cause drug-induced parkinsonism
2
Q
What drugs show zero order kinetics
A
Phenytoin, ethanol - enzymes become saturated so the rate of elimination is not proportional to [drug]
3
Q
Name a potent interaction
A
Oral contraceptives can reduce plasma concentrations of lamotrigine
