Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Neuro IV > Drugs of Abuse > Flashcards

Drugs of Abuse Flashcards

1
Q

List 5 drugs of OPIOIDS class

A
  1. Heroin*
  2. Morphine
  3. Fentanyl
  4. Oxycodone
  5. Hydrocodone
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

*List 8 drugs of BENZODIAZEPINES

A
  1. Diazepam
  2. Midazolam
  3. Lorazepam
  4. Alprazolam
  5. Flurazepam
  6. Oxazepam
  7. Triazolam
  8. Temazepam

Note: All end with “am”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

*List 2 drugs of BARBITURATES

A
  1. Pentobarbital

2. Phenobarbital*

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

*List 3 categories (ctg) of CNS Depressant

A
  1. Ethanol
  2. Benzodiazepine
  3. Barbiturate
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

*List 3 ctg of CNS Stimulants

A
  1. Cocaine
  2. Amphetamine/Methylphenidate/Methamphetamine
  3. Nicotine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

List 2 ctg of Hallucinogens

A
  1. Indoleamine

2 Phenylethylamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

List 3 drugs of INDOLEAMINES

A
  1. LSD
  2. Psilocybin
  3. Bufotenine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

List 2 drugs of PHENYLETHYLAMINE

A
  1. MDMA

2. Mescaline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Most representative drug of class DISSOCIATIVE ANESTHETICS

A

Phencyclidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Give 1 example of CANNABINOIDS class

A

Marijuana

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

MoA of OPIOIDS

A

Agonist at mu-opioid receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Effect of OPIOIDS (2)

A
  1. Euphoria

2. Sedation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Acute Toxicity of OPIOIDS (3)

A
  1. Respiratory depression
  2. Miosis
  3. Coma
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

3 life-threatening effect of OPIODS toxicity

A
  1. Death
  2. Arrhythmias
  3. Convulsion
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Treatment for OPIOIDS toxicity

A

Naloxone (IV/SC)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Tolerance for OPIOIDS

A
  1. Develop rapidly (up 100x increase)

2. NO develop constipation or miosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Dependence of OPIOIDS

A

Develop rapidly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Withdrawal of OPIOIDS is life-threatening (T/F)

A

False

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Treatment for OPIOIDS withdrawal

A
  1. Clonidine (decrease SNS signs)

2. Methadone (via cross-dependence)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

6 Symptoms can be seen with OPIOID withdrawal

A
  1. Insomia
  2. increase HR
  3. Increase BP
  4. Diarrhea
  5. Muscle aches
  6. Cramps
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Effects of CNS Depressant (3)

A
  1. Anxiolysis
  2. Sedation
  3. Loss of inhibition
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

*Toxicity of CNS Depressant

A
  1. RR depression

2. Coma –> death!!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

*Acute Toxicity rarely seen with which type of CNS Depressant drug?

A

BDZs (require presence of GABA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

*Tolerance of CNS Depressant

A
  1. rapid to barbiturate > ethanol

2. significant to sedation-intoxication, less lethal dose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

*Withdrawal risk of CNS Depressant

A

Seizure –> Death!!

26
Q

*Treatment of CNS Depressant Withdrawal

A

Substitute to BDZ –> dose taper to prevent seizure

27
Q

*ETHANOL and BARBITURATE MoA (2)

A
  1. Facilitate GABA fxn

2. Inhibit Glu-NMDA fxn

28
Q

*BDZs MoA

A

Facilitate GABA fxn

29
Q

*Treatment ETHANOL Toxicity

A

Supportive + Fluid-Thiamine-Electrolytes

30
Q

*Treatment BDZs Toxicity

RARE!! unless combine with other CNS Depressant

A

Flumazenil

31
Q

*Treatment Barbiturate Toxicity

A

Supportive

32
Q

What is the use of following in Withdrawal treatment of BDZs

  1. Buspirone
  2. *Carbamazepine, *Phenobarbital
A
  1. Buspirone for anxiety

2. *Carbamazepine, Phenobarbital for anticonvulsant

33
Q

*Treatments for ALCOHOL relapse? (2)

A
  1. Disulfiram

2. Naltrexone

34
Q

*MoA of Disulfiram in reducing alcohol consumption

A

Alcohol sensitizing drugs

35
Q

*MoA of Naltrexone in reducing alcohol consumption

A

(Opioid antagonist)
Reduce alcohol craving, consumption and relapse rate
Use in combination with psychotheraphy

36
Q
  • Stages of ETHANOL withdrawal
    1. 6-48 hrs
    2. 12-48 hrs
    3. 48-96 hrs
A
  1. Seizure (6-48 hrs)
  2. Visual hallucination (12-48 hrs)
  3. Delirium (48-96 hrs)
37
Q

*MoA of Cocaine

A

inhibits monoamine reuptake transporter

38
Q

*MoA of Amphetamine/Methamphetamine

A

stimulate monoamine release

39
Q

*Effects of COCAINE and AMPHETAMINE/METHAMPHETAMINE (4)

A
  1. Euphoria
  2. Decrease fatigue
  3. Increase arousal and confidence
  4. Appetite suppression
40
Q

*Acute toxicity of COCAINE and AMPHETAMINE/METHAMPHETAMINE (5)
Hint: heart problem

A

SNS overactivity with

  1. Dilated pupils
  2. increase BP
  3. increase HR
  4. Seizure
  5. MI
41
Q

*Treatment for COCAINE and AMPHETAMINE/METHAMPHETAMINE acute toxicity (3)

A
  1. Cardiovascular support
  2. Vasodilator for BP
  3. BDZs for agitation/seizure
42
Q

*Tolerance of COCAINE and AMPHETAMINE/METHAMPHETAMINE (4)

A

Tolerance to:

  1. Euphoria
  2. Anorexia
  3. Hyperthermia
  4. Supersensitivity to paranoia
43
Q

*Withdrawal of COCAINE and AMPHETAMINE/METHAMPHETAMINE (5)

A
  1. Depression
  2. Sleepiness
  3. Fatigue
  4. Hyperphagia (abnormal increase appetite)
  5. Craving
44
Q

*Dependence of COCAINE and AMPHETAMINE/METHAMPHETAMINE

A

Arguable due to lack obvious physiological symptoms

45
Q

*Treatment of COCAINE and AMPHETAMINE/METHAMPHETAMINE Withdrawal

A

Behavioral

46
Q

*MoA of Nicotine

A

Nicotinic cholinergic receptor Agonist

47
Q

*Effect of Nicotine

A

increase alertness

48
Q

*Acute toxicity of Nicotine (5)

Rare unless ingestion

A
  1. Nausea & vomiting
  2. Diarrhea
  3. Hypotension
  4. Difficult breathing
  5. Convulsion –> DEATH!!
49
Q

*Treatment for Nicotine Toxicity (4)

A
  1. CVP support
  2. emetics
  3. gastric lavage
  4. charcoal
50
Q
  • Tolerance to Nicotine (2)
A

Tolerance to

  1. Subjective effects
  2. Nausea
51
Q
  • Dependence of Nicotine
A

Moderate development

52
Q
  • Withdrawal of Nicotine (5)
A
  1. Irritability
  2. Hostility
  3. Anxiety
  4. increase appetite
  5. Weight gain
53
Q
  • Treatment for Nicotine relapse
A
  1. Nicotine replacement
    AND
  2. Bupropion OR varenicline
54
Q
  • Bupropion MoA
A

NDRI

55
Q
  • Marijuana MoA
A

agonist at cannabinoid receptor - CB1

56
Q
  • Marijuana Effect (3)
A
  1. Euphoria
  2. Mellowness
  3. Changes in perception, mood, motivation
57
Q
  • Acute Toxicity of Marijuana (3)
A
  1. Impaired coordination
  2. tracking behavior
  3. acute psychosis
58
Q
  • Marijuana Tolerance
A

Tolerance develops rapidly, disappears rapidly

59
Q
  • Marijuana Dependence
A

Abuse potential = moderate

60
Q
  • Marijuana Withdrawal
A

No clinically significant due to long half-life

61
Q
  • Symptoms seen with Marijuana Withdrawal (4)

following chronic high doses

A
  1. Malaise
  2. Headache
  3. Anxiety
  4. Nausea
62
Q
  • Treatment for Marijuana Withdrawal
A

Usually NOT needed

Neuro IV (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions