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Neuro IV > Anxiolytic Agents > Flashcards

Anxiolytic Agents Flashcards

1
Q

Dosages in the therapeutic range for both benzodiazepine (BZDs) and barbiturates (BARBs)? (5)

A
  1. Anti-anxiety
  2. Anti-convulsant
  3. Muscle Relaxant
  4. Sedative
  5. Hypnotic
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2
Q

Adverse Reaction (AdR) of BARBs? (2)

A
  1. Coma

2. Medullary depression

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3
Q

AdR of BZD (2)

A
  1. Anterograde amnesia

2. Drownsiness

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4
Q

Effect of Sedative-Hypnotic Drugs on GABA and GLU

A
  1. Augment GABA neuronal inhibition

2. Inhibit GLU neuronal excitation

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5
Q

Primary approach to Anxiety treatment

A

Enhance 5HT and GABA activity

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6
Q

List of BDZs drugs could be used for Anxiolytics (8)

A
  1. Alprazolam
  2. Flurazepam
  3. Diazepam
  4. Oxazepam
  5. Triazolam
  6. Lorazepam
  7. Midazolam
  8. Temazepam
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7
Q

List Non-BDZ BDZ agonist drugs for Anxiolytics (3)

A
  1. Zolpidem
  2. Eszopiclone
  3. Zaleplon
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8
Q

Class of Ramelteon

A

Melatonin Receptor Agonist

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9
Q

Drug act as Melatonin Receptor Agonist for Anxiolytics

A

Ramelteon

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10
Q

Diphenhydramine

A

found more

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11
Q

Which is the first line for treatment of anxiety?

A

SSRI and SNRI

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12
Q

….. and ….. act on 5HT to treat anxiety

A
  1. SSRI-SNRI

2. Buspirone

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13
Q

…. and ….. act on GABA channel to treat anxiety

A
  1. BDZs

2. Barbiturate

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14
Q

Effect of sedative drugs (3)

A
  1. decrease activity
  2. moderate excitement
  3. calm the recipient
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15
Q

Effect of hypnotic drugs

A
  1. Produce drowsiness

2. Maintenance of sleep

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16
Q

What is the drug of choice for STATUS EPILEPTICUS?

A

Diazepam (BDZ)

17
Q

Higher doses of ….. and ….. inhibit seizure activity in cortical neurons

A
  1. barbiturates

2. benzodiazepines

18
Q

Higher doses of barbiturates and benzodiazepines inhibit seizure activity in ……

A

cortical neurons

19
Q

Pharmacologic Effect of BDZ from lowest to highest dose (3)

A
  1. Muscle relaxation
  2. Hypnosis
  3. Anesthesia
20
Q

Which anxiety treatment is NOT capable of induce surginal anesthesia?

A

BDZs

21
Q

Treatment for Panic Disorder (4)

A
  1. Take person through it help them!!!
  2. BDZ
  3. TCADs, MAO inhibitor, SNRI, SSRI
  4. Cognitive behavioral therapy
22
Q

Treatment for Social Phobia (2)

A
  1. Beta-blocker

2. Cognitive behavioral therapy

23
Q

Generalized anxiety disorder treatment (2)

A
  1. buspirone

2. Cognitive

24
Q

OCD treatment (5)

A
  1. Clomipramine
  2. SSRI
  3. Atypical anti-psychotic
  4. behavioral
  5. Neurosurgery
25
Q

Adverse reaction for Cabamazepine (3)

A
  1. Diploxia-ataxia-sedation
  2. GI Upset
  3. (Rare but serious)
    a. Aplastic anemia-agranulocytosis
    b. Hepatotoxicity
26
Q

Pharmacokinetics of Cabamazepine

A

Strong inducer CYP450

27
Q

Usage for Carbamazepine (2)

A
  1. Partial seizure

2. Tonic-clonic 1st choice

Neuro IV (4 decks)

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