drugs of abuse Flashcards
Opioids examples
heroin, oxycodone and hydrocodone
CNS depressants examples
barbiturates, benzodiazepines, alcohol
CNS stimulants examples
methamphetamines, cocaine,
hallucinogens examples
Indoleamines (LSD, DMT, mushrooms), Phenylethylamines (MDMA, mescaline)
dissociative anesthetics examples
Phencyclidine (PCP), ketamine, dextromethorphan
Pharmacologic property of drugs of abuse
enhance dopamine activity in the nucleus accumbens
levels of drug abuse
experimental (one-few trials), circumstantial-recreational (occasional use under certain circumstances), and compulsive (reliance)
pathway of addiction
Amygdala learns drug and cues cause pleasure–may signal relief from craving > Drug cues lead to DA release in Nucleus accumbens > triggers output to thalamus and cortex > In absence of activity from reflective reward system (prefrontal cortex) drug-seeking initiated
Opioids MOA
Agonists at μ-opioid receptors [Gi]
CNS depressants MOA
Enhance GABA - inhibit glutamate
CNS stimulants MOA
Block DA reuptake or enhance DA release
nicotine MOA
Agonist at nicotinic neuronal receptors
hallucinogens MOA
Partial agonist at 5HT2 receptors
dissociative anesthetics MOA
Antagonist at NMDA-Glu receptors
cannabinoids MOA
Agonist at cannabinoid (CB1-CB2) receptors
Opioids reinforcing effects
Opioids: Euphoria, sedation, anxiolytic
CNS depressants reinforcing effects
CNS Depressants: Euphoria, sedation, loss of inhibition
CNS stimulants reinforcing effects
CNS Stimulants: Euphoria, decreased fatigue, increased arousal
nicotine reinforcing effects
Nicotine: Increased alertness
hallucinogens reinforcing effects
Hallucinogens: Altered sensory perception, enhanced insight
dissociative anesthetics reinforcing effects
Dissociative Anesthetics: Euphoria, heightened emotionality
cannabinoids reinforcing effects
Cannabinoids: Euphoria, “mellowness”, changes in perception