Drugs mechanism of action

Question 1

Clopidogrel

Answer 1

ADP (Adenosine-diphosphate receptor) Antagonist

Question 2

Aspirin

Answer 2

cyclo-oxygenase inhibitor.

Question 3

Dabigatran and bivalirudin

Answer 3

thrombin inhibitors.

Question 4

Tirofiban and abciximab

Answer 4

are glycoprotein IIb/IIIa inhibitors.

Question 5

Warfarin inhibits

Answer 5

production of factors II, VII, IX and X (1972)

inhibiting epoxide reductase preventing Vitamin K from being converted to its activated form

Question 6

Dipyridamole

Answer 6

Antiplatelet that is combined with aspirin.

FACT: used for ischaemic stroke or transient ischaemic attack.

Question 7

Amiodarone

Answer 7

Blocking potassium channels which inhibits repolarisation and hence prolongs the action potential.

Question 8

Angiotensin-converting enzyme (ACE) inhibitors

Answer 8

inhibit the conversion angiotensin I to angiotensin II

Question 9

Furosemide

Answer 9

inhibits the Na-K-Cl cotransporter in the thick ascending limb of the loop of Henle

Question 10

Nicorandil

Answer 10

potassium-channel activator —> mediated vasodilation is through activation of guanylyl cyclase which results in increase cGMP

Question 11

Coronary artery bypass procedure

Answer 11

Great saphenous vein –> using a graft from the internal mammary artery ( bypassing the stenosed coronary vasculature)