Drugs Inhibiting SAN Flashcards
Feature of alpha adrenergic receptor antagonists
Effect on lowering bp through blocking a1 receptors
What is the selective a1A receptor antagonist and what is it used for
Tamsulosin
Antagonizes sympathetic control of bladder and relaxes sm in bladder beck,prostate capsule and prostatic urethra and decrease resistance to outflow of urine
Management of benign prostatic hyperplasia
What is a selective a1 receptor antagonist
Prazosin
What is an irreversible non selective a receptor antagonist and what does it do
Phenoxybenazmine
Irreversibly blocks the a receptor by a covalent binding
Prevents excessive stimulation of these receptors
Provides long term protection against hypertension till time of surgery
Combined with b receptor blocker to protect heart from arrhythmogenic effect
What is a reversible non selective a receptor antagonist and what does it do
Phentolamine
Short acting competitive antagonist that reduces peripheral resistance and dec blood pressure
What is the characteristic adverse reaction of a receptor antagonist
Postural hypotension
Treatment should be started with lower doses and inc gradually
Most likely with tamsulosin
What is the general function of b adrenergic receptor antagonists
Intended to inhibit sympathetic over-activation of heart required in hypertension ischemic heart disease arrhythmia and heart failure
Non selective agents blocking both b1 and b2
Propranolol
Selective agents blocking only b1 receptors
Metoprolol
Atenolol
Bisoprolol
Non selective agents with a blocking
Carvedilol
Labetalol
Has local anesthetic effect
Propranolol
Drugs that are lipid soluble
Propanol
Metoprolol
Water soluble drugs
Atenolol
Used for hypertension
Nebivolol
Angina pectoris
Blockade of b1 receptors dec cardiac work to fit within the compromised blood supply in ischemia
