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Pharmacology: Kaplan, Uworld, FA > Drugs inflammatory and related disorder_ drugs used for Rx of Rheumatoid arthritis > Flashcards

Drugs inflammatory and related disorder_ drugs used for Rx of Rheumatoid arthritis Flashcards

1
Q

__________ stabilizes lysosomes and decreases chemotaxis

A

Hydroxychloroquine

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2
Q

Side effects of Hydroxychloroquine

A

GI distress and visual dysfunction (Cinchonism), hemolysis in G6PD deficiency

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3
Q

Cinchonism

A

visual dysfunction

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4
Q

______ is cytotoxic to lymphocytes

A

methotrexate

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5
Q

side effects of methotrexate

A

causes _________ hematotxicity, hepatoxicity

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6
Q

______ where sulfapridine —>decrease B-cell functions; 5-ASA possibly inhibits COX

A

Sulfasalazine

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7
Q

Sulfasalazine side effects

A

hemolysis in G6PD deficiency

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8
Q

________ decreases LTs, ILs and platelet-activating factor (PAF)

A

Glucocorticoids

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9
Q

Glucocorticoids side effects

A

ACTH suppression, Cushingoid state, osteoporosis, GI distress, glaucoma

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10
Q

_______ inhibits dihydro-orotic acid dehydragenase (DHOD) —> decrease UMP —> decrease ribonucleotides—->arrests lymphocytes in G1 phase

A

Leflunomide

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11
Q

Leflunomide side effects

A

alopecia, rash, diarrhea, heptotoxicity

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12
Q

_______ binds tumor necrosis factor (TNF); is a recombinant form of TNF receptor

A

Etanercept

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13
Q

Etanercept side effects

A

infections

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14
Q

_________ is recombinant form of TNF receptor

A

Etanercept

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15
Q

________ are monoclonal antibody to TNF

A

infliximab ; adalimumab

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16
Q

infliximab ; adalimumab side effects

A

infections

17
Q

________ is IL-1 receptor antagonist

A

anakinra

18
Q

side effects of anakinra

A

infections

19
Q

______ are used commonly in Rx of RA but doses required results in adverse effects

A

NSAIDs

20
Q

NSAIDs decrease ____/_____ but have no beneficial effect on course of disease or on bone deterioration

A

Pain and swelling

21
Q

Disease-modifying antirheumatic drugs

A

DMARDs

22
Q

DMARDs slows the progression of ______

A

disease

23
Q

DMARDs can be started with _________ at time of initial Dx if symptoms are severe b/c DMARDs take 2 wks - 6 months to work

A

NSAIDs

24
Q

DMARDs takes _____ wks to _____ months to work

A

2 and 6

25
Q

what is recommended for mild arthritis?

A

hydroxychloroquine

26
Q

what is recommended for moderate to severe RA

A

Methotrexate (MTX)

Pharmacology: Kaplan, Uworld, FA (9 decks)

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