Drugs inflammatory and related disorder_ drugs used for Rx of Rheumatoid arthritis Flashcards
__________ stabilizes lysosomes and decreases chemotaxis
Hydroxychloroquine
Side effects of Hydroxychloroquine
GI distress and visual dysfunction (Cinchonism), hemolysis in G6PD deficiency
Cinchonism
visual dysfunction
______ is cytotoxic to lymphocytes
methotrexate
side effects of methotrexate
causes _________ hematotxicity, hepatoxicity
______ where sulfapridine —>decrease B-cell functions; 5-ASA possibly inhibits COX
Sulfasalazine
Sulfasalazine side effects
hemolysis in G6PD deficiency
________ decreases LTs, ILs and platelet-activating factor (PAF)
Glucocorticoids
Glucocorticoids side effects
ACTH suppression, Cushingoid state, osteoporosis, GI distress, glaucoma
_______ inhibits dihydro-orotic acid dehydragenase (DHOD) —> decrease UMP —> decrease ribonucleotides—->arrests lymphocytes in G1 phase
Leflunomide
Leflunomide side effects
alopecia, rash, diarrhea, heptotoxicity
_______ binds tumor necrosis factor (TNF); is a recombinant form of TNF receptor
Etanercept
Etanercept side effects
infections
_________ is recombinant form of TNF receptor
Etanercept
________ are monoclonal antibody to TNF
infliximab ; adalimumab
infliximab ; adalimumab side effects
infections
________ is IL-1 receptor antagonist
anakinra
side effects of anakinra
infections
______ are used commonly in Rx of RA but doses required results in adverse effects
NSAIDs
NSAIDs decrease ____/_____ but have no beneficial effect on course of disease or on bone deterioration
Pain and swelling
Disease-modifying antirheumatic drugs
DMARDs
DMARDs slows the progression of ______
disease
DMARDs can be started with _________ at time of initial Dx if symptoms are severe b/c DMARDs take 2 wks - 6 months to work
NSAIDs
DMARDs takes _____ wks to _____ months to work
2 and 6
what is recommended for mild arthritis?
hydroxychloroquine
what is recommended for moderate to severe RA
Methotrexate (MTX)
