Drugs inflammatory and related disorder_ drugs acting on Serotonergic systems

Question 1

5HT

Answer 1

Serotonin (5-hydroxytrptamine)

Question 2

_________ is autacoid synthesized and stored in GI cells, neurons, and platelets

Answer 2

Serotonin (5HT)

Question 3

5HT is metabolized by ___________ and its metabolite 5-hyrdoxyinolacetic acid (5HIAA), a marker for carcinoid

Answer 3

MAO type A

Question 4

metabolite 5-hyrdoxyinolacetic acid (5HIAA) from

Answer 4

serotonin

Question 5

ALL serotonin are G-coupled except______ which is coupled directly to ion channel

Answer 5

5HT3

Question 6

_________ is found in CNS (usually inhibitory) and smooth muscle (excitatory or inhibitory)

Answer 6

5HT1 (a-h)

Question 7

partial agonists at 5HT-1a receptors

Answer 7

Buspirone (anxiolytic used in generalized anxiety disorder GAD))

Question 8

Agonists at 5HT-1d receptors in cerebral vessels

Answer 8

Sumatriptan and other “triptans” (decreases migraines)

Question 9

Side effects of sumatriptan and other “triptans”

Answer 9

possible asthenia (physical weakness, low energy), chest or throat pressure or pain

Question 10

drug used for Rx of generalized anxiety disorder

Answer 10

buspirone

Question 11

drug used for Rx of migraine

Answer 11

sumatriptan and other triptans

Question 12

5HT2 (a-c) is found in _________ that is excitatory

Answer 12

CNS

Question 13

5HT 2(a-c) activation in periphery leads to

Answer 13

vasodilation, contraction of GI, bronchial and uterine smooth muscle and platelet aggregation

Question 14

Drugs acting on 5HT2 (a-c)

Answer 14

Olanzapine and cyproheptadine

Question 15

___________ and other atypical antipsychotic are antagonists at 5HT2a receptors in CNS leading to decreased symptoms of __________

Answer 15

Olanzapine; psychosis

Question 16

__________ 5HT2 antagonist used in carcinoid and other GI tumors and postgastroectomy; as well as anorexia nervosa and serotonin syndrome

Answer 16

Cyproheptadine

Question 17

_____ has H1-blocking action which is used in seasonal allergy

Answer 17

Cyproheptadine

Question 18

5HT3 is found in ________/________/__________; it works by activation of open ion channels (no 2nd messengers)

Answer 18

Area postrema; peripheral sensory; enteric nerves

Question 19

drugs of 5HT3

Answer 19

ondansetron and “_setrons”

Question 20

ondansetron is ___________ that decreases emesis in chemotherapy and radiation and postoperatively

Answer 20

Antagonists

Question 21

Drugs used in migraine headaches

Answer 21

sumatriptan/ “_triptans” agonist at 5HT 1d; ergot alkaloids (Ergotamine)

Question 22

mechanism of action of Ergotamine

Answer 22

acts as partial agonists at both alpha and 5HT2 receptors in vasculature and possibly in CNS; it has vasoconstrictive actions to decreased pulsation in cerebral vessels relevant to acute actions of ergotamine (rx migraine attack)

Question 23

Uses of ergotamine

Answer 23

acute attacks (migraine and others)

Question 24

Side effects of ergotamine

Answer 24

GI distress; prolonged vasoconstriction leading to ischemia and gangrene, abortion near term

Question 25

in addition to “___triptans” and ergots, analgesic such as ____ used in migraine

Answer 25

ASA (+/- caffeine, or butabarbital) NSAIDS, acetaminophen(+/- caffeine) , oral or injectable opioid-analgesics and butorphanol (spray)

Question 26

Prophylaxis in migraine in addition to “triptans”/ ergots

Answer 26

Propranolol, verapamil, amitriptyline, valproic acid

Question 27

________ causes uterine smooth muscle contraction that is given intramuscularily after placental delivery

Answer 27

Ergonovine