Drugs in Synaptic Transmission

Question 1

Antagonist of AchR

Used to paralyze patients during surgery

Answer 1

tubocarine

Question 2

agonist of AchR

Answer 2

nicotine

Question 3

peptide from venome of branded krait

poison that irreversibly block AchR –> muscle paralysis

Answer 3

alpha-bungarotoxin

Question 4

Shorting acting cholinesterase inhibitor

used in treatment of myasthenia gravis

Answer 4

edrophonium

Question 5

irreversible inhibitor of cholinesterase

Answer 5

organophosphorus in certain pesticides and sarin “nerve gas”