Drugs for Peptic Ulcer Disease Flashcards
PUD
erosion of gut wall; imbalance of defensive factors and aggressive factors
defensive factors of gut
Mucus-protective barrier
Bicarbonate-neutralizes acid
Blood flow-maintain mucosal integrity
Prostaglandins-stimulate secretion of mucus and bicarb, enhance blood flow
Common causes/Aggressive factors: PUD
H. Pylori infection-bacteria-most common NSAIDs Gastric acids Pepsin Smoking
peptic ulcer
an ulcer occurring in the esophagus, stomach, or duodenum; occur from hypersecretion of hydrochloric acid and pepsin
Treatment Options for Peptic Ulcer Disease
Nonpharmacologic measures Antibiotics Antisecretory Agents Mucosal Protectants Antisecretory Agents Antacids
PUD non-drug therapy
in addition to drugs; Diet (small meals) Smoking cessation, avoid NSAIDs
Treatment Options for Peptic Ulcer Disease: antibiotics
Clarithromycin Amoxicillin Bismuth (Pepto Bismol)-OTC Metronidazole Tetracycline
Treatment for PUD-H2 Receptor Antagonists
suppressing the secretion of gastric acid; Cimetidine Ranitidine Famotidine Nizatidine
Cimetidine
on empty stomach
CNS depression/stimulation/ reduced libido
duo 4-6 weeks/gas 8-12
antacids an hour apart
Treatment for PUD-Proton Pump Inhibitors
most effective for suppressing gastric acid; lowest dose for shortest time-limited 4-8 weeks;
omeprazole
Omeprazole (enteric coated)
N/V, diarrhea Increase risk for fractures (osteoporosis) Pneumonia Acid rebound Intestinal infection (C-diff) Hypomagnesemia Lots of drug interactions (CAN BE LONG TERM HYPERSECRETORY)
EMPTY STOMACH IN AM
Treatment for PUD-Antiulcer Drugs
ulcer healing by creating a protective barrier; no acid-neutralizing capacity and does not decrease acid secretions
Sulcrafate
Sulcrafate
sulfated sucrose and aluminum hydroxide
Side effects (very minimal): Constipation Lacks significant drug interactions
empty stomach at least 30 min to 2 hours from food or drugs.
Can impede the absorption of phenytoin, theophylline, digoxin, warfarin, Cipro
Treatment for PUD-Antacids
neutralize stomach acid; PUD & GERD; drug interactions, take at least 1 hour spaced apart;
Aluminum hydroxide
Magnesium hydroxide
Calcium carbonate
Aluminum hydroxide
Magnesium hydroxide
Calcium carbonate
side effects
Constipation (aluminum hydroxide)
Diarrhea (magnesium hydroxide)
Hypertension
