drugs for parkinsonsim and alzheimers disease

Question 1

blood brain barrier

Answer 1

endothelial cells in capillary walls in the brain have tight junctures

Question 2

what is parkinsonism?

Answer 2

slow movement, tremors, shuffleing gait, pill rolling

Question 3

what causes parkinsons disease?

Answer 3

too much acetylcholine and not enough dopamine

Question 4

how do you treat parkinsons disease?

Answer 4

give more dopamine

Question 5

what drug class is carbidopa-levodopa sinemet?

Answer 5

antiparkinson agent

Question 6

how does carbidopa-levodopa work?

Answer 6

levodopa- converted to dopamine in the cns

carbidopa- gets the levodopa to the brain

Question 7

does dopamine pass the blood brain barrier?

Answer 7

no

Question 8

what are some contraindications of carbidopa-levodopa?

Answer 8

closed angle glaucoma, cv disease, hepatic disease, psychiatric disease, peptic ulcer

Question 9

what interferes with carbidopa-levodopa?

Answer 9

high protein intake, high levels of b6

Question 10

what are some side effects of carbidopa levodopa?

Answer 10

involuntary movement, mood change, cardiac dysarrythmia, ortho hypo, dark urine or sweat, nausea, vomiting

Question 11

what are some nursing implications for cabidopa levodopa?

Answer 11

may take 1-4 weeks to work, dont stop abruptley, urine and sweat discoloration is normal, admin with low protein foods

Question 12

alzheimers disease

Answer 12

incurable dementia

Question 13

how do you treat alzheimers disease?

Answer 13

increase acetycholene

Question 14

what drug class is exelon?

Answer 14

acetylcholinersterase inhibitor

Question 15

how does exelon work?

Answer 15

inhibits the breakdown of acetylcholine in the cns but does not cure the disease

Question 16

does exelon stablalize cognitive function?

Answer 16

yes

Question 17

what are some contraindicaions of exelon?

Answer 17

urinary obstruction, ortho hypo, bradycardia, asthma, peptic ulcer disease

Question 18

side effects of exelon?

Answer 18

hepatotoxicity, anorexia, nausea, vomiting, bradycardia, ortho hypo, dry mouth

Question 19

nursing implications

Answer 19

assiss cognitive function throughout therapy
holistic approach to care
monitor liver function
admin at regular intervals on an empty stomach

Question 20

should you avoind anticholinergic or dopamine agents with exelon?

Answer 20

antichollinergic