Drugs For Oswald Flashcards
Adipex-P
Lonamin
Short term use (few weeks)
Inc Norepinephrine and dopamine
ADRs Inc BP Cardiomyopathy Insomnia Dec libido
Centrally acting
Diethylpropion
Short term
MOA: unknown for weight loss
ADRs;
Cardiomyopathy
Impotence
Phendimetrazine
Short term
MOA: Stimulation of hypothalamus and norepinephrine
ADRs
Hypertension
Agitation
Benzphetamine
Short term (3 weeks or less)
MOA: Simulation of hypothalamus and norepinephrine
ADRs
Cardiomyopathy
Hypertension
Depression w/ withdrawal
Centrally acting
Contrave
Bupropion and Naltraxone
Long term: D/C is <5% loss in 12 weeks
MOA: Inc norepinephrine and dopamine
ADRs
BBW - suicidalality and antidepressant drugs
Centrally acting
Qysmia
Phentermine and Topiramate
Long term - D/C is <5% weight loss in 12 weeks
MOA: inc norepinephrine and maybe gaba and carbonic anhydase, topirmate = want to eat less
ADRs:
REMS - congenital malformation in 1st trimester (no PREGO)!
Central
Belviq
Locaserin
Long term; D/C is <5% weight loss in 12 weeks
MOA:
Inc serotonin
ADRs:
Possible serotonin syndrome (watch for a pt that is also on an SSRI med) (SIADH bonus answer as well)
Saxenda
Liraglutide
Long term: D/C is <4% of weight loss at 16 weeks
MOA:
GLP1 agonist,
Inc satiety and dec food intake
ADRs:
BBW - Thyroid C-cell tumor risk
Increase HR
Central
Alli
Xenical
Orlistat (OTC for Overweight pt)
Xenical = for obese pts
Long term: D/C is <5% weight loss at 12 weeks
MOA:
Pancreatic and gastric lipase inhibitor
COUNSEL PT:
Take Vit (ADEK) for as long as you use it
Limit fat to <15gm per meal
Skip taking if not meal or no fat
ADRs:
Shart , don’t use in pt with CKD and can cause hepatotoxicity
Peripheral acting
Common issues with Pts who get bariatric surgery
Early dumping
Avoid hyperosmolar liquids, sugary drink and high carb meals
Increase high protein meals and eat smaller more frequent meals
Prone to deficiencies
Fat-soluble vitamins (ADEK)
Calcium and Vit D
Give Calcium citrate and Vit D
Anemia due to inadequate absorption of
Iron
B12
Folate
