Drugs for Obesity

Question 1

Incretins:

Answer 1

• Proteins that facilitate communication between the gut and the brain
• Orginally used to treat Type 2 Diabetes

Question 2

2 Types of Incretins:

Answer 2

1. Glucagon- like Peptides (GLP-1)
2. Glucose- dependent insulinotropic peptide (GIP)

-These drugs increase insulin secretion, decrease glucagon secretion, delay gastric secretions and reduce appetite.

Question 3

Liraglutide:

Answer 3

• Glucagon- like peptide agonist (incretin)
• Delays gastric emptying/ promotes satiety
• Reduces appetite
• MUST be injected
• AE’s: Pancreatitis (inflammation of the Pancreas)
• Only incretin that been approved for Obesity

Question 4

GI Lipase Inhibitors:

Answer 4

• Lipases normally break down fat molecules for absorption
• GI Lipase inhibitors reduce fat absorption, as well as they are likely to reduce fat intake
• ->Horrible GI tract side effects: Diarrhea

Question 5

Orlistat:

Answer 5

-GI Lipase Inhibitor
-Effective and safe
AE: Steatorrhea (fatty stools)