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Pulmonary Pharm > Drugs for Lung Cancer > Flashcards

Drugs for Lung Cancer Flashcards

1
Q

When is bevacizumab not recommended?

A

squamous cell carcinomas because it can lead to severe bleeding and increased cavitation.
Also when there is hemoptysis or brain metastases

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2
Q

What mutations can render erlotinib inneffective?

A

KRAS mutations because the proliferative pathway remains active downstream of the drug blockade

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3
Q

Which mutations are more common in non-smokers?

A

EGFR, EML4-ALK, and hMSH2

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4
Q

What is treatment for SCLC?

A

etoposide and cisplatin or carboplatin. Surgery is typically not an option because of early metastisis

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5
Q

What is treatment for NSCLC?

A

cisplatin AND paclitaxel, gemcitabine, docetaxel.

If EGFR positive use erlotinb. Bevacizumab for those with non-squamous histo or hemoptysis.

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6
Q

What is MOA of carboplatin?

A

forms DNA intrastrand crosslinks and adducts

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7
Q

What is MOA of cisplatin?

A

forms DNA intrastrand crosslinks and adducts

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8
Q

What is MOA of cyclophosphamide?

A

pro-drug of active alkylating moiety

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9
Q

What is MOA of doxorubicin?

A

intercalator, free radical generator, topo II inhibitor

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10
Q

What is MOA of etoposide?

A

DNA topo II complex stabilizer

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11
Q

What is MOA of gemcitabine?

A

DNA polymerase inhibitor via incorporation of triphosphate form during DNA synthesis

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12
Q

What is MOA of ifosfamide?

A

intra and inter-strand cross linker

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13
Q

What is MOA of irnotecan?

A

DNA-topo I complex stabilizer

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14
Q

What is MOA of paclitaxel?

A

microtubule stabilizer inhibition depolymerization

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15
Q

What is MOA of pemetrexed?

A

DHFR inhbitor

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16
Q

What is MOA of topotecan?

A

DNA topo I complex stabilizer

17
Q

What is MOA of vincristine?

A

microtubule inhibitor, tubules disintegrate int spiral aggregates/ protofilaments.

18
Q

What is MOA of vinorelbine?

A

microtubule inhibitor, tubules disintegrate int spiral aggregates/ protofilaments.

19
Q

What are main adverse effects of carboplatin?

A

platinum allergies, myelosuppression, anemia, increased hepatic enzymes, BUN and creatinine.

20
Q

What are main adverse effects of cisplatin?

A

platinum allergies, nephrotoxicity, myelosuppression and ototoxicity

21
Q

What are main adverse effects of cyclophosphamide?

A

anemia, renal compromise, hemorrhagic cstitis, pulmonary fibrosis

22
Q

What are main adverse effects of doxorubicin?

A

myelosuppression, CHF, hepatic disease

23
Q

What are main adverse effects of etoposide?

A

myelosuppression, hematologic toxicity, alopecia

24
Q

What are main adverse effects of gemcitabine?

A

arthralgia, fatigue, peripheral neuropathy

25
Q

What are main adverse effects of ifosfamide?

A

alopecia, neurotoxicity, hematuria renal failure

26
Q

What are main adverse effects of irinotecan?

A

myelosuppression, diarrhea, asthenia

27
Q

What are main adverse effects of paclitaxel?

A

taxane hypersensitivity, myalgia and arthalgia

28
Q

What are main adverse effects of pemetrexed?

A

GI toxicity. Elevated LFTs and creatinine. Can’t combine with cisplatin because of GI toxicity

29
Q

What are main adverse effects of topotecan?

A

GI toxicity, hyperbilirubinemia

30
Q

What are main adverse effects of vinblastine?

A

neuropathic toxicity, neutropenia

31
Q

What are main adverse effects of vinorelbine?

A

myelosuppression, neuropathic toxicity, neutropenia.

32
Q

What is MOA of erlotinib?

A

reversible inhibitor selective for EGFR

33
Q

What are main adverse effects of erlotinib?

A

liver and kidney problems, corneal perforations and rash

Pulmonary Pharm (6 decks)

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