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Pharma > Drugs for hypertension & angina > Flashcards

Drugs for hypertension & angina Flashcards

0
Q

Drug class of amlodipine

A

Calcium channel blocker (dihydropyridine)

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1
Q

Blood pressure goal in hypertensive patients with no comorbidities?

A

< 140/90

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2
Q

Toxicities of methyldopa

A

Hemolytic anemia, positive coombs test

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3
Q

Blood pressure goal in hypertensive patients with no comorbidities?

A

< 140/90

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4
Q

Drug class of amlodipine

A

Calcium channel blocker (dihydropyridine)

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5
Q

Drug class of nitroprusside

A

Vasodilator (parenteral)

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6
Q

Drug class of prazosin

A

Adrenergic blocker (alpha1 selective)

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7
Q

Toxicities of methyldopa

A

Hemolytic anemia, positive coombs test

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9
Q

Blood pressure goal in hypertensive patients with diabetes mellitus?

A

< 130/90

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10
Q

Drug class of losartan, valsartan, candesartan

A

Angiotensin receptor blocker (ARB)

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11
Q

Drug class of nicardipine

A

Calcium channel blocker (dihydropyridine)

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12
Q

Antihypertensive drug that can cause cyanide toxicity

A

Nitroprusside

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13
Q

Drug class of bumetanide

A

Loop diuretic

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14
Q

Drug class of methyldopa

A

CNS sympathetic outflow blocker

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16
Q

Drug class of nitroprusside

A

Vasodilator (parenteral)

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17
Q

Drug class of prazosin

A

Adrenergic blocker (alpha1 selective)

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19
Q

Drug class of fenoldopam

A

Parenteral vasodilator, dopamine agonist

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20
Q

Drug class of clonidine

A

CNS Sympathetic outflow blocker

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21
Q

Drug class of verapamil

A

Calcium channel blocker (non dihydropyridine)

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22
Q

Treatment for rebound hypertension caused by clonidine

A

Phentolamine

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23
Q

Drug class of hexamethonium

A

Sympathoplegic (ganglion blocker)

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24
Q

Drug class of hydrochlorothiazide

A

Thiazide Diuretics

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25
Q

Drug class of Reserpine

A

Sympathoplegic (nerve terminal blockers)

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27
Q

Effect of 1st dose prazosin, tamsulosin

A

Orthostatic hypotension

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28
Q

Anti hypertensive use for pre eclampsia

A

Methyldopa, hydralazine

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29
Q

Drug class of propranolol

A

Adrenergic blocker (beta nonselective)

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30
Q

MOA of thiazide diuretic

A

Inhibit Na/Cl transporter in distal convoluted tubule

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31
Q

Drug class of amlodipine

A

Calcium channel blocker (dihydropyridine)

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32
Q

Drug class of hydralazine

A

Vasodilator

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33
Q

Antihypertensive drugs that are use for SVT

A

Verapamil

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34
Q

MOA of loop diuretic

A

Inhibit Na/K/2Cl transporter in thick ascending limb of loop of henle

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35
Q

Antihypertensive use for pulmonary edema

A

Loop diuretic (ex furosemide)

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36
Q

MOA of CNS sympathetic outflow blockers?

A

Activates alpha 2 adrenergic receptors

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37
Q

MOA of ganglion blockers?

A

Competitively blocks Nn nicotinic Ach receptors

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38
Q

MOA of nerve terminal blockers?

A

Irreversibly blocks the vesicular monoamine transporter (VMAT)

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39
Q

MOA of adrenergic blocker prazosin?

A

Selectively blocks alpha1 adrenergic receptors

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40
Q

Antihypertensive drugs that causes drug induced lupus

A

Oral Vasodilator (hydralazine)

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41
Q

Blood pressure goal in hypertensive patients with diabetes mellitus?

A

< 130/90

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42
Q

MOA of adrenergic blocker propranolol?

A

Blocks beta1 and beta2 receptors. Blocks sympathetic effect on heart and BP. Reduces renin release.

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43
Q

Drug class of losartan, valsartan, candesartan

A

Angiotensin receptor blocker (ARB)

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44
Q

MOA of non dihydropyridine CCB

A

Block voltage gated L type Ca+ channels (cardiac>vascular)

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45
Q

MOA of dihydropydrine CCB

A

Block voltage gated channel L type Ca+ channels (vascular>cardiac)

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46
Q

Drug class of minoxidil

A

Vasodilator

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47
Q

MOA of parenteral vasodilator

A

Relaxes venous arteriolar smooth muscle, activation of guanyly cyclase (release of NO)

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48
Q

Antihypertensive drugs: cough & angioedema as side effect

A

ACE inhibitor (“pril” family)

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49
Q

BP range of stage 1 HPN according to JNC7

A

140-159/90-99

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50
Q

Toxicities of nerve terminal blocker

A

Suicidal ideation, severe psyche depression

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51
Q

Antihypertensive contraindicated in asthmatics

A

Adrenergic antagonist (propranolol, timolol, carvedilol)

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52
Q

BP range of stage 2 HPN according to JNC7

A

> 160/>100

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53
Q

Drug class of Aliskerin

A

Renin antagonist

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54
Q

Adrenergic blocker that is most selective for prostatic smooth muscle

A

Tamsulosin

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55
Q

Antihypertensive drugs that candelap progression of diabetic nephropathy

A

ACE inhibitor, ARB

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56
Q

Antihypertensive drugs that mask symptoms of hypoglycemia in diabetics

A

Adrenergic antagonist (ex. Propranolo, timolol, labetalol)

How well did you know this?
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2
3
4
5
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57
Q

Antihypertensive drugs that are use for angina

A

dihydropyridine CCB (ex. nifedipine, nicardipine)

58
Q

MOA of ARB

A

Blocks AT1 receptors in vascular smooth muscle and adrenal cortex

59
Q

Treatment for malignat HPN

A

Vasodilators (nitroprusside, fenoldopam) with diuretics (furosemid) and beta blockers

60
Q

Drug class of amyl nitrite

A

Ultra short acting nitrate

61
Q

Drug class of nitroglycerin, ISDN, ISMN

A

Short acting nitrate

62
Q

Drug class of captopril, enalapril

A

ACE inhibitor

63
Q

Disease cause by occupational exposure to nitrates

A

Monday disease

64
Q

Antihypertensive drug use for reynaud’s phenomenon

A

Diltiazem

65
Q

1st line drug for angina

A

Nitroglycerin

66
Q

Antihypertensive drugs use for angina prophylaxis

A

Beta blockers

67
Q

Treatment for cyanide poisoning

A

Inhaled amyl nitrite + IV sodium nitrite + IV sodium thiosulfate

68
Q

Drug class of diltiazem

A

Calcium channel blocker (non dihydropyridine)

69
Q

MOA of ACE inhibitors

A

Inhibits ACE to convert angiotensin I to angiotensin II. Decrease aldosterone secretion

70
Q

Meds that causes drug induced lupus

A

Hydralazine, isoniazid, procainamide, penicillamine

71
Q

Toxicities of non dihydropyridine CCB (verapamil, diltiazem)

A

Gingival hyperplasia, AV block

72
Q

Drug class of nicardipine

A

Calcium channel blocker (dihydropyridine)

73
Q

Antihypertensive drugs that causes hypertrichosis

A

Oral vasodilator (minoxidil)

74
Q

Antihypertensive drug that can cause cyanide toxicity

A

Nitroprusside

75
Q

MOA of renin antagonist

A

Inhibits renin to convrt angiotensinogen to angiotensin I

76
Q

Drug class of bumetanide

A

Loop diuretic

77
Q

1st line drugs for hypertension

A

Thiazide diuretic

78
Q

Effects of loop diuretics

A

Dehydration, hypokalemia, ototoxicity, hyperuricemia

79
Q

Drug class of methyldopa

A

CNS sympathetic outflow blocker

80
Q

Effects of clonidine

A

Rebound hypertension, sedation

81
Q

Blood pressure goal in hypertensive patients with chronic kidney disease?

A

< 130/80

86
Q

Drug class of fenoldopam

A

Parenteral vasodilator, dopamine agonist

87
Q

Drug class of clonidine

A

CNS Sympathetic outflow blocker

88
Q

Drug class of verapamil

A

Calcium channel blocker (non dihydropyridine)

89
Q

Treatment for rebound hypertension caused by clonidine

A

Phentolamine

90
Q

Drug class of hexamethonium

A

Sympathoplegic (ganglion blocker)

91
Q

Drug class of hydrochlorothiazide

A

Thiazide Diuretics

92
Q

Drug class of Reserpine

A

Sympathoplegic (nerve terminal blockers)

94
Q

Effect of 1st dose prazosin, tamsulosin

A

Orthostatic hypotension

95
Q

Anti hypertensive use for pre eclampsia

A

Methyldopa, hydralazine

96
Q

Drug class of propranolol

A

Adrenergic blocker (beta nonselective)

97
Q

MOA of thiazide diuretic

A

Inhibit Na/Cl transporter in distal convoluted tubule

98
Q

Drug class of amlodipine

A

Calcium channel blocker (dihydropyridine)

99
Q

Drug class of hydralazine

A

Vasodilator

100
Q

Antihypertensive drugs that are use for SVT

A

Verapamil

101
Q

MOA of loop diuretic

A

Inhibit Na/K/2Cl transporter in thick ascending limb of loop of henle

102
Q

Antihypertensive use for pulmonary edema

A

Loop diuretic (ex furosemide)

103
Q

MOA of CNS sympathetic outflow blockers?

A

Activates alpha 2 adrenergic receptors

104
Q

MOA of ganglion blockers?

A

Competitively blocks Nn nicotinic Ach receptors

105
Q

MOA of nerve terminal blockers?

A

Irreversibly blocks the vesicular monoamine transporter (VMAT)

106
Q

MOA of adrenergic blocker prazosin?

A

Selectively blocks alpha1 adrenergic receptors

107
Q

Antihypertensive drugs that causes drug induced lupus

A

Oral Vasodilator (hydralazine)

109
Q

MOA of adrenergic blocker propranolol?

A

Blocks beta1 and beta2 receptors. Blocks sympathetic effect on heart and BP. Reduces renin release.

111
Q

MOA of non dihydropyridine CCB

A

Block voltage gated L type Ca+ channels (cardiac>vascular)

112
Q

MOA of dihydropydrine CCB

A

Block voltage gated channel L type Ca+ channels (vascular>cardiac)

113
Q

Drug class of minoxidil

A

Vasodilator

114
Q

MOA of parenteral vasodilator

A

Relaxes venous arteriolar smooth muscle, activation of guanyly cyclase (release of NO)

115
Q

Antihypertensive drugs: cough & angioedema as side effect

A

ACE inhibitor (“pril” family)

116
Q

BP range of stage 1 HPN according to JNC7

A

140-159/90-99

117
Q

Toxicities of nerve terminal blocker

A

Suicidal ideation, severe psyche depression

118
Q

Antihypertensive contraindicated in asthmatics

A

Adrenergic antagonist (propranolol, timolol, carvedilol)

119
Q

BP range of stage 2 HPN according to JNC7

A

> 160/>100

120
Q

Drug class of Aliskerin

A

Renin antagonist

121
Q

Adrenergic blocker that is most selective for prostatic smooth muscle

A

Tamsulosin

122
Q

Antihypertensive drugs that candelap progression of diabetic nephropathy

A

ACE inhibitor, ARB

123
Q

Antihypertensive drugs that mask symptoms of hypoglycemia in diabetics

A

Adrenergic antagonist (ex. Propranolo, timolol, labetalol)

124
Q

Antihypertensive drugs that are use for angina

A

dihydropyridine CCB (ex. nifedipine, nicardipine)

125
Q

MOA of ARB

A

Blocks AT1 receptors in vascular smooth muscle and adrenal cortex

126
Q

Treatment for malignat HPN

A

Vasodilators (nitroprusside, fenoldopam) with diuretics (furosemid) and beta blockers

127
Q

Drug class of amyl nitrite

A

Ultra short acting nitrate

128
Q

Drug class of nitroglycerin, ISDN, ISMN

A

Short acting nitrate

129
Q

Drug class of captopril, enalapril

A

ACE inhibitor

130
Q

Disease cause by occupational exposure to nitrates

A

Monday disease

131
Q

Antihypertensive drug use for reynaud’s phenomenon

A

Diltiazem

132
Q

1st line drug for angina

A

Nitroglycerin

133
Q

Antihypertensive drugs use for angina prophylaxis

A

Beta blockers

134
Q

Treatment for cyanide poisoning

A

Inhaled amyl nitrite + IV sodium nitrite + IV sodium thiosulfate

135
Q

Drug class of diltiazem

A

Calcium channel blocker (non dihydropyridine)

136
Q

MOA of ACE inhibitors

A

Inhibits ACE to convert angiotensin I to angiotensin II. Decrease aldosterone secretion

137
Q

Meds that causes drug induced lupus

A

Hydralazine, isoniazid, procainamide, penicillamine

138
Q

Toxicities of non dihydropyridine CCB (verapamil, diltiazem)

A

Gingival hyperplasia, AV block

140
Q

Antihypertensive drugs that causes hypertrichosis

A

Oral vasodilator (minoxidil)

142
Q

MOA of renin antagonist

A

Inhibits renin to convrt angiotensinogen to angiotensin I

144
Q

1st line drugs for hypertension

A

Thiazide diuretic

145
Q

Effects of loop diuretics

A

Dehydration, hypokalemia, ototoxicity, hyperuricemia

147
Q

Effects of clonidine

A

Rebound hypertension, sedation

148
Q

Blood pressure goal in hypertensive patients with chronic kidney disease?

A

< 130/80

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