Drugs for Glaucoma

Question 1

Class: non-selective beta-blocker

MOA: blocks beta-1 and beta-2 receptors, DECREASES SECRETION OF AQUEOUS HUMOR from the ciliary epithelium

Answer 1

TIMOLOL

Question 2

Class: osmotic agent

MOA: DECREASES SECRETION OF AQUEOUS HUMOR from the ciliary epithelium

Answer 2

MANNITOL

Question 3

Class: selective alpha-2-agonist

MOA: selectively activates alpha-2 receptors, DECREASES SECRETION OF AQUEOUS HUMOR from the ciliary epithelium

Answer 3

APRACLONIDINE

Question 4

Class: carbonic anhydrase inhibitor

MOA: DECREASES SECRETION OF AQUEOUS HUMOR from the ciliary epithelium

Answer 4

ACETAZOLAMIDE, DORZOLAMIDE

Question 5

Class: cholinomimetic (direct-acting, muscarinic)

MOA: selective activation of M3 receptor, ciliary muscle contraction, opening of trabecular meshwork, INCREASES AQUEOUS HUMOR OUTFLOW

Answer 5

PILOCARPINE

Question 6

Class: cholinomimetic (indirect-acting)

MOA: inhibits acetylecholinesterase, ampliflies endogenously-released ACh, ciliary muscle contraction, opening of trabecular meshwork, INCREASES AQUEOUS HUMOR OUTFLOW

Answer 6

PHYSOSTIGMINE

Question 7

Class: prostaglandin

MOA: INCREASES AQUEOUS HUMOR OUTFLOW through canal of Schlemm

Answer 7

LATANOPROST

Question 8

Class: non-selective alpha-agonist

MOA: activates alpha-1 and alpha-2 receptors, INCREASES AQUEOUS OUTFLOW via uveoscleral veins

Answer 8

EPINEPHRINE