drugs for eating

Question 1

Lorcaserin

Answer 1

• agonist for seratonin
• targets POMC neurons (anorexigenic)
• FMRI limbic system = decreased emotion and salviency activity

Question 2

• agonist for seratonin
• targets POMC neurons (agonist)
• FMRI limbic system = decreased emotion and salviency activity

Answer 2

lorcaserin

Question 3

Benzphetamine

Answer 3

• noradrenergic agonist
• enhances mainly norepinephrine, dopaime and seratonin in CNS
• not completely understood

Question 4

• noradrenergic agonist
• enhances mainly norepinephrine, dopaime and seratonin in CNS
• not completely understood

Answer 4

Benzphetamine

Question 5

phentermine and topiramate

Answer 5

combination suppresses appetite
- poorly understood
- phentermine : enhances release of norepinephrine and dopamine
- Topiramate : GABA agonised, glutamate antagonist

Question 6

combination suppresses appetite
- poorly understood
- phentermine : enhances release of norepinephrine and dopamine
- Topiramate : GABA agonised, glutamate antagonist

Answer 6

phentermine and topiramate

Question 7

Naltrexone and Bupropion

Answer 7

• weight loss side effect
• work together to increase POMC peptide production
• and other anorexigenics
• FMRI showed changes in response to food in hypothalamus

Question 8

• weight loss side effect
• work together to increase POMC peptide production
• and other anorexigenics
• FMRI showed changes in response to food in hypothalamus

Answer 8

Naltrexone and bupropion

Question 9

Liraglutide

Answer 9

GLP-1 analogue
- blood glucose regulation
- slows gastric emptying
- hypothalamus= limbic/reward system
- reward system decreases and intake of palatable foods
- anorexigenic pathway

Question 10

orilstat

Answer 10

Inhibits gastrointestinal and pancreatic
lipases
■ Reduced fatty acid absorption
■ 1/3 of fatty acids in food not absorbed

Question 11

Inhibits gastrointestinal and pancreatic
lipases
■ Reduced fatty acid absorption
■ 1/3 of fatty acids in food not absorbed

Answer 11

orlistat